Browse by Phase
Phase 1 Clinical Trials
Phase 1 trials test a new drug or treatment in a small group (20–80 people) for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects.
Total Trials
107
Recruiting Now
107
Top Conditions in Phase 1
Frequently Asked Questions — Phase 1 Trials
What is tested in a Phase 1 clinical trial?
Phase 1 trials test a new drug or treatment in a small group of 20–80 people for the first time. The primary goals are to evaluate safety, determine a safe dosage range, identify side effects, and study how the drug is metabolized and excreted. Phase 1 trials typically enroll patients with the target condition who have exhausted standard treatment options, or healthy volunteers in some cases.
How long do Phase 1 clinical trials last?
Phase 1 trials typically last several months to one year depending on the drug, dose-escalation protocol, and follow-up period. The relatively small patient cohort and focused safety objectives make Phase 1 the shortest stage in clinical development. Some are extended into Phase 1/2 combined designs to simultaneously gather early efficacy signals.
Are Phase 1 clinical trials safe to join?
Phase 1 trials are the first human tests of a new intervention and carry the most uncertainty about safety. All Phase 1 studies must be approved by an Institutional Review Board (IRB) and operate under strict FDA oversight. Participants receive intensive monitoring throughout the study. While risks exist, Phase 1 protocols use conservative dosing and frequent safety assessments to protect participants.
Active Phase 1 Studies
NCT07323173 Phase 1
Recruiting
A Phase I Study to Assess LBL-047 in Healthy Adults and Patients With Systemic L...
Condition
Systemic Lupus Erythematosus
Enrollment
112 pts
Location
China
Sponsor
Nanjing Leads Biolabs Co.,Ltd
NCT07473713 Phase 1
Recruiting
Veverimer to Decrease Net Acid Excretion and Bone Resorption in Adults With Oste...
Condition
Osteopenia
Enrollment
60 pts
Location
United States
Sponsor
Tufts Medical Center
NCT07249879 Phase 1
Recruiting
This Study is an Open-lable, Early Study to Evaluate the Safety, Feasibility, Cy...
Condition
Relapsed/Refractory Small Cell Lung Cancer
Enrollment
55 pts
Location
China
Sponsor
Cancer Institute and Hospital,
NCT06738966 Phase 1
Recruiting
A Study of BL0175 Injection in Postmenopausal Female Adults With HR-positive, Lo...
Condition
Breast Cancer
Enrollment
9 pts
Location
China
Sponsor
Shanghai Best-Link Bioscience,
NCT06418061 Phase 1
Recruiting
Study of IBI3005 in Subjects With Unresectable, Locally Advanced or Metastatic S...
Condition
Unresectable
Enrollment
198 pts
Location
China
Sponsor
Innovent Biologics (Suzhou) Co
NCT06966388 Phase 1
Recruiting
Study to Evaluate the Feasibility of Twice Daily Use of Topical Azelaic Acid in ...
Condition
Breast Cancer
Enrollment
33 pts
Location
United States
Sponsor
Virginia Commonwealth Universi
NCT03294954 Phase 1
Recruiting
GD2 Specific CAR and Interleukin-15 Expressing Autologous NKT Cells to Treat Chi...
Condition
Neuroblastoma
Enrollment
70 pts
Location
United States
Sponsor
Baylor College of Medicine
NCT06515470 Phase 1
Recruiting
Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of BTX-9341 in ...
Condition
Breast Cancer
Enrollment
82 pts
Location
United States
Sponsor
Biotheryx, Inc.
NCT07448623 Phase 1
Recruiting
A Research Study to Look at the Distribution and Effects of Coramitug on Amyloid...
Condition
Transthyretin Amyloid Cardiomyopathy
Enrollment
14 pts
Location
Netherlands
Sponsor
Novo Nordisk A/S
NCT05329103 Phase 1
Recruiting
A Study to Evaluate PEEL-224 in Patients With Advanced Solid Tumors
Condition
Advanced Solid Tumor
Enrollment
65 pts
Location
United States
Sponsor
Peel Therapeutics Inc
NCT05430373 Phase 1
Recruiting
GT101 Injection for the Treatment of Metastatic or Recurrent Solid Tumors
Condition
Solid Tumors, Adult
Enrollment
31 pts
Location
China
Sponsor
Grit Biotechnology
NCT06062745 Phase 1
Recruiting
Pilot Study for Detection of PSMA-Low CRPC-NE Tumors With Fluciclovine PET/CT
Condition
Advanced Prostate Cancer
Enrollment
30 pts
Location
United States
Sponsor
Brigham and Women's Hospital
NCT07100119 Phase 1
Recruiting
A Study of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis
Condition
ALS (Amyotrophic Lateral Sclerosis)
Enrollment
32 pts
Location
Belgium, Canada, Germany
Sponsor
Eli Lilly and Company
NCT07133828 Phase 1
Recruiting
A Study to Learn About the Safety of BIIB142 and How it is Processed in the Body...
Condition
Healthy Volunteer
Enrollment
78 pts
Location
United States
Sponsor
Biogen
NCT06028373 Phase 1
Recruiting
A Study of ATG-031 in Advanced Solid Tumors or B-cell Non-Hodgkin Lymphomas
Condition
Advanced Solid Tumors
Enrollment
80 pts
Location
United States
Sponsor
Antengene Biologics Limited
NCT06400537 Phase 1
Recruiting
Clinical Study of A-319 in the Treatment of Active/Refractory Systemic Lupus Ery...
Condition
Systemic Lupus Erythematosus
Enrollment
25 pts
Location
China
Sponsor
Union Hospital, Tongji Medical
NCT06503783 Phase 1
Recruiting
A Study of BL-M17D1 in Patients With Locally Advanced or Metastatic HER2 Positiv...
Condition
Breast Cancer
Enrollment
20 pts
Location
China
Sponsor
Sichuan Baili Pharmaceutical C
NCT06085937 Phase 1
Recruiting
Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Depart...
Condition
Suicide
Enrollment
50 pts
Location
United States
Sponsor
Lindsay Maguire, MD
NCT05773001 Phase 1
Recruiting
Macrophage Regulation of Ozone-Induced Lung Inflammation
Condition
SARS-CoV-2 Pneumonia
Enrollment
100 pts
Location
United States
Sponsor
Robert Tighe, MD
NCT06546969 Phase 1
Recruiting
Chemoimmunotherapy Combined With Hyperthermia and Spatially-Fractionated Radioth...
Condition
Biliary Tract Cancer
Enrollment
15 pts
Location
United States
Sponsor
University of Maryland, Baltim
NCT05835986 Phase 1
Recruiting
A First-in-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics...
Condition
Systemic Lupus Erythematosus
Enrollment
70 pts
Location
Colombia, France, Germany
Sponsor
Hoffmann-La Roche
NCT05426681 Phase 1
Recruiting
Spinal Cord Injury Neuroprotection With Glyburide
Condition
Acute Spinal Cord Injury
Enrollment
12 pts
Location
United States
Sponsor
Francis Farhadi
NCT06814730 Phase 1
Recruiting
A Study to Assess THN391 in Subjects With Alzheimer's Disease
Condition
Alzheimer Disease, Early Onset
Enrollment
15 pts
Location
Netherlands, United Kingdom
Sponsor
Therini Bio, Inc.
NCT07476183 Phase 1
Recruiting
Assessing the Safety, Tolerability, and Efficacy of APR-2020 in Pediatric and Ad...
Condition
RPS19 Deficient Diamond-Blackfan Anemia
Enrollment
4 pts
Location
United States
Sponsor
Apriligen, Inc.
NCT07516405 Phase 1
Recruiting
Safety and Tolerability Trial of Psilocybin in Healthy Older Adults
Condition
Healthy Volunteer
Enrollment
40 pts
Location
United States
Sponsor
University of Colorado, Denver
Page 1 of 5 — 107 trials total
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology