Clinical Trials / Browse by Phase / Phase 1
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Phase 1 Clinical Trials

Phase 1 trials test a new drug or treatment in a small group (20–80 people) for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects.

Total Trials
604
Recruiting Now
604
Top Conditions in Phase 1
Advanced Solid Tumor (23) Solid Tumor (21) Advanced Solid Tumors (18) Healthy (18) Breast Cancer (16) Ovarian Cancer (15) Acute Myeloid Leukemia (15) Healthy Volunteers (14) Colorectal Cancer (10) Healthy Participants (9)
NCT06642363 Phase 1
Recruiting
The Effectiveness of Astaxanthin Supplementation on the Clinical Symptoms and Ca...
Condition
PCO - Polycystic Ovaries
Enrollment
44 pts
Location
Iran
Sponsor
Isfahan University of Medical
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NCT06500793 Phase 1
Recruiting
Single Dose Study, Pharmacokinetics of Oxycodone and PF614 Co-Administered With ...
Condition
Pharmacokinetics
Enrollment
30 pts
Location
United States
Sponsor
Ensysce Biosciences
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NCT07301333 Phase 1
Recruiting
A Study of Single and Multiple Doses of HRS-6257 in Healthy Subjects
Condition
Pain
Enrollment
80 pts
Location
China
Sponsor
Shanghai Hengrui Pharmaceutica
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NCT06962332 Phase 1
Recruiting
Pharmacokinetics (PK) and Safety of Zanzalintinib in Participants With Moderate ...
Condition
Hepatic Impairment
Enrollment
20 pts
Location
United States
Sponsor
Exelixis
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NCT06809699 Phase 1
Recruiting
Human Leukocyte Antigen (HLA) Mismatched Related Allogeneic Hematopoietic Stem C...
Condition
Hematologic Diseases
Enrollment
29 pts
Location
China
Sponsor
He Huang
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NCT04427293 Phase 1
Recruiting
Preoperative Lenvatinib Plus Pembrolizumab in Early-Stage Triple-Negative Breast...
Condition
Triple Negative Breast Cancer
Enrollment
12 pts
Location
United States
Sponsor
University of Illinois at Chic
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NCT06964009 Phase 1
Recruiting
DT2216 + Paclitaxel in Platinum-Resistant Ovarian Cancer
Condition
Ovarian Cancer
Enrollment
30 pts
Location
United States
Sponsor
Elizabeth Stover, MD, PhD
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NCT05378464 Phase 1
Recruiting
Adoptive T Cell Therapy Following HER2-Pulsed Dendritic Cell Vaccine & Pepinemab...
Condition
HER2-positive Breast Cancer
Enrollment
28 pts
Location
United States
Sponsor
H. Lee Moffitt Cancer Center a
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NCT07310134 Phase 1
Recruiting
Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and E...
Condition
Advanced Solid Tumors
Enrollment
80 pts
Location
China
Sponsor
Nanjing Zenshine Pharmaceutica
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NCT07234864 Phase 1
Recruiting
Study to Assess Safety, Tolerability, PK, and PD of Multiple Doses of ZE63-0302 ...
Condition
Type 2 Diabetes
Enrollment
60 pts
Location
Australia, Uzbekistan
Sponsor
Eilean Therapeutics
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NCT05190471 Phase 1
Recruiting
A Clinical Trial of BP1002 in Patients With Refractory/Relapsed Acute Myeloid Le...
Condition
Acute Myeloid Leukemia, in Relapse
Enrollment
48 pts
Location
United States
Sponsor
Bio-Path Holdings, Inc.
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NCT06699771 Phase 1
Recruiting
Phase 1 to Investigate the Safety, Tolerability, and Efficacy of GCC2005 in Pati...
Condition
Lymphoma, T-Cell
Enrollment
48 pts
Location
South Korea
Sponsor
GC Cell Corporation
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NCT05787587 Phase 1
Recruiting
A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors
Condition
Advanced or Metastatic Solid Tumors
Enrollment
216 pts
Location
United States
Sponsor
IDEAYA Biosciences
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NCT07450521 Phase 1
Recruiting
Evaluation of MTX-463 Administered Subcutaneously in Healthy Adult Males
Condition
Healthy Adult Male
Enrollment
8 pts
Location
United States
Sponsor
Mediar Therapeutics
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NCT07396909 Phase 1
Recruiting
A First-in-Human Single and Multiple Ascending Dose Study of MT-701
Condition
Healthy Volunteers
Enrollment
78 pts
Location
United States
Sponsor
Mirador Therapeutics, Inc.
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NCT04429087 Phase 1
Recruiting
A Study to Test Different Doses of BI 764532 in Patients With Small Cell Lung Ca...
Condition
Patients With Small Cell Lung Carcinoma and Other Neoplasms
Enrollment
300 pts
Location
United States, Germany, Japan
Sponsor
Boehringer Ingelheim
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NCT05445063 Phase 1
Recruiting
Safety and Efficacy of Autologous Transplantation of iPSC-RPE in the Treatment o...
Condition
Macular Degeneration
Enrollment
10 pts
Location
China
Sponsor
Beijing Tongren Hospital
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NCT06609187 Phase 1
Recruiting
A Study of GNC-077 in Patients With Locally Advanced or Metastatic Breast Cancer...
Condition
Breast Cancer
Enrollment
20 pts
Location
China
Sponsor
Sichuan Baili Pharmaceutical C
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NCT06882096 Phase 1
Recruiting
Tracing the Metabolic Flux of Orally Administered NAD+ Precursors
Condition
Healthy Adults
Enrollment
32 pts
Location
United States
Sponsor
Metro International Biotech, L
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NCT06484556 Phase 1
Recruiting
T Cell Receptor Gene-Engineered T Cell Therapy Targeting KRAS Mutations in the T...
Condition
Tumor, Solid
Enrollment
9 pts
Location
China
Sponsor
Tao Zhang
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NCT07042945 Phase 1
Recruiting
MK-4646 Multiple Dose Trial in Participants With Human Immunodeficiency Virus Ty...
Condition
HIV Infection
Enrollment
28 pts
Location
Moldova, Romania
Sponsor
Merck Sharp & Dohme LLC
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NCT06823167 Phase 1
Recruiting
A Phase 1 Study of IM-1021 in Participants With Advanced Cancer
Condition
Solid Malignancies
Enrollment
117 pts
Location
United States, Spain
Sponsor
Immunome, Inc.
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NCT05818683 Phase 1
Recruiting
A Study of JNJ-78278343 in Combination With Either JNJ-63723283 (Cetrelimab), Ta...
Condition
Metastatic Castration-resistant Prostate Neoplasms
Enrollment
277 pts
Location
United States, Australia, Spain
Sponsor
Janssen Research & Development
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NCT03721822 Phase 1
Recruiting
Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation
Condition
Smoking, Cigarette
Enrollment
100 pts
Location
United States
Sponsor
University of Pennsylvania
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NCT06995729 Phase 1
Recruiting
A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Chi...
Condition
Acute Treatment of Migraine
Enrollment
16 pts
Location
United States
Sponsor
Pfizer
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Page 1 of 25 — 604 trials total
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