Medical Condition

healthy volunteer

Total Trials

13

Recruiting Now

13

Trial Phases

Phase 1

Clinical trials often recruit healthy volunteers for Phase 1 pharmacokinetic and safety studies, vaccine immunogenicity assessments, and normal physiological reference studies. These trials are essential for establishing safe dose ranges and understanding how drugs behave in the absence of disease before testing in patient populations.

Healthy volunteer studies include first-in-human drug trials, vaccine efficacy (flu, RSV, COVID-19, malaria), microbiome intervention studies, exercise physiology research, and device safety assessments. Compensation is often provided; eligibility typically requires no significant medical history and a negative drug screen.

Healthy volunteer trials require participants to be in good general health with no significant medications. Many exclude smokers, pregnant individuals, and those with recent prior trial participation.

Frequently Asked Questions — healthy volunteer Clinical Trials

How many clinical trials are currently recruiting for healthy volunteer?

ClinicalMetric currently tracks 13 actively recruiting clinical trials for healthy volunteer, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 13. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for healthy volunteer?

healthy volunteer research spans Phase 1 (8 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a healthy volunteer clinical trial?

Eligibility criteria for healthy volunteer trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Top Sponsors

AbbVie 3 trials

Seismic Therapeutic AU Pty Ltd 2 trials

Yonsei University 1 trial

The University of Texas Health Science Center at San Antonio 1 trial

National Institute on Alcohol Abuse and Alcoholism (NIAAA) 1 trial

Recruiting Clinical Trials

NCT06231953

Recruiting

A Prospective, Multi-center Clinical Study to Establish Multi-Cancer Early Detection Platform Through the Analysis of Whole Genome Sequencing of Circulating DNA in Cancer Patients and Healthy Volunteers

Phosphatidylethanol and Other Ethanol Consumption Markers

The University of Texas Health...

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NCT06828393 Phase 1

Recruiting

A Phase 1 Study of S-1117

Seismic Therapeutic AU Pty Ltd

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NCT06819189 Phase 1

Recruiting

Role of Metal Ion Transporter ZIP8 in Alcohol-Related Behaviors

National Institute on Alcohol ...

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NCT04354064

Recruiting

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

Washington University School o...

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NCT07649954 Phase 1

Recruiting

A Study to Evaluate How Multiple Doses of Itraconazole Interacts With Nacresertib in Healthy Adult Participants

A Study to Assess the Adverse Events and How Oral Emraclidine Moves Through the Body of Healthy Elderly Adult Participants

A Safety and Pharmacokinetics Study of TL-003 in Healthy Adults and Open-label Assessments in Participants With Ulcerative Colitis

TrueLab Biopharmaceutical Co.,...

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NCT06633081

Recruiting

Smartphone Addiction and Isometric Strength of Rotator Cuff Muscles

Effect of LIMICOL®-NG on Plasma LDL-cholesterol Concentration in Subjects with Moderate Hypercholesterolemia

Institut Pasteur de Lille

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NCT06877611 Phase 1

Recruiting

A Phase 1 Study of S-4321

Seismic Therapeutic AU Pty Ltd

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NCT07782775 Phase 1

Recruiting

A Study to Assess the Bioequivalence of Efgartigimod PH20 SC Between Autoinjector and Prefilled Syringe in Healthy Adult Participants

A Study to Assess the Adverse Events and How Oral ABBV-1042 Moves Through the Body of Healthy Adult Participants

Related Conditions

invasive cancer (1) alcohol consumption (1) prostate cancer (1) head and neck cancer (1) esophageal cancer (1) genitourinary cancer (1) sarcoma (1) breast cancer (1) colon cancer (1) gastrointestinal cancer (1) solid tumor cancer (1) lung cancer (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology