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healthy volunteer

Total Trials

16

Recruiting Now

16

Trial Phases

Phase 1, Phase 1, Phase 2

Clinical trials often recruit healthy volunteers for Phase 1 pharmacokinetic and safety studies, vaccine immunogenicity assessments, and normal physiological reference studies. These trials are essential for establishing safe dose ranges and understanding how drugs behave in the absence of disease before testing in patient populations.

Healthy volunteer studies include first-in-human drug trials, vaccine efficacy (flu, RSV, COVID-19, malaria), microbiome intervention studies, exercise physiology research, and device safety assessments. Compensation is often provided; eligibility typically requires no significant medical history and a negative drug screen.

Healthy volunteer trials require participants to be in good general health with no significant medications. Many exclude smokers, pregnant individuals, and those with recent prior trial participation.

Frequently Asked Questions — healthy volunteer Clinical Trials

How many clinical trials are currently recruiting for healthy volunteer?

ClinicalMetric currently tracks 16 actively recruiting clinical trials for healthy volunteer, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 16. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for healthy volunteer?

healthy volunteer research spans Phase 1 (11 trials), Phase 2 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a healthy volunteer clinical trial?

Eligibility criteria for healthy volunteer trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

11

Phase 2

1

Top Sponsors

Biogen 2 trials

AbbVie 2 trials

Skolkovo Institute of Science and Technology 1 trial

Seismic Therapeutic AU Pty Ltd 1 trial

Pfizer 1 trial

Recruiting Clinical Trials

NCT07225517 Phase 1

A Study to Learn More About the Safety of BIIB145 and How it is Processed in the Body of Healthy Adult Participants

Study of Visual Perception Phenomena: Phosphene Mapping Induced by TMS and Its Relationship With Eye Movements

Skolkovo Institute of Science ...

NCT06828393 Phase 1

A Phase 1 Study of S-1117

Seismic Therapeutic AU Pty Ltd

NCT07215078 Phase 1

Study About Whether Atirmociclib/PF-07220060 Proportionally Increases Exposure as Dose Increases in Healthy Participants

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

Washington University School o...

NCT07051629 Phase 1

Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients

Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease

University of Alabama at Birmi...

NCT07395024 Phase 1

A Study to Learn How Fluconazole, Carbamazepine and Itraconazole Affect How the Body Processes ASP3082 in Healthy Adults

Astellas Pharma Global Develop...

Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)

National Institute of Dental a...

NCT07219030 Phase 1

A Study to Assess the Adverse Events and How Oral Emraclidine Moves Through the Body of Healthy Elderly Adult Participants

NCT06819189 Phase 1

Role of Metal Ion Transporter ZIP8 in Alcohol-Related Behaviors

National Institute on Alcohol ...

NCT07219368 Phase 1

A First-in-Human Single and Multiple Ascending Dose Study of MT-201

Mirador Therapeutics, Inc.

Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial

National Institute on Aging (N...

NCT07605806 Phase 1, Phase 2

Novel Biomarkers of Non-IgE Immediate Hypersensitivity Drug Reactions

Johns Hopkins University

NCT07133828 Phase 1

A Study to Learn About the Safety of BIIB142 and How it is Processed in the Body of Healthy Adult Participants Aged 18 to 55 Years Old

NCT07570147 Phase 1

A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Single Ascending Doses of ABBV-1451 Infusions and Injections in Healthy Adult Participants

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology