State PA
Clinical Trials in Pennsylvania
Pennsylvania is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Pennsylvania and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 481 actively recruiting studies with Pennsylvania sites out of 481 registered in total. The busiest research areas in Pennsylvania are Breast Cancer, Acute Myeloid Leukemia, Ovarian Cancer. Leading sponsors running trials in the state include University of Pennsylvania, University of Pittsburgh, National Cancer Institute (NCI). By stage, Pennsylvania trials break down as Phase 1 (77), Phase 2 (124), Phase 3 (115), Phase 4 (15).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Pennsylvania
Frequently Asked Questions — Clinical Trials in Pennsylvania
How many clinical trials are currently recruiting in Pennsylvania?
ClinicalMetric currently tracks 481 actively recruiting clinical trials with at least one location in Pennsylvania. The total number of registered studies—including active but not currently enrolling trials—is 481. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Pennsylvania?
Pennsylvania hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Acute Myeloid Leukemia, Ovarian Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Pennsylvania serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Pennsylvania?
To join a clinical trial in Pennsylvania, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Pennsylvania maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Pennsylvania
NCT04369560 EARLY_Phase 1
Recruiting
Virtual Histology of the Bladder Wall for Bladder Cancer Staging
Condition
Urinary Bladder Neoplasms
Enrollment
42 pts
Location
United States
Sponsor
Jodi Maranchie
NCT05685303 N/A
Recruiting
Alleviant ALLAY-HF Study
Condition
Heart Failure
Enrollment
700 pts
Location
United States, Australia, Austria
Sponsor
Alleviant Medical, Inc.
NCT03396341 N/A
Recruiting
Responses to Genetic Risk Modifier Testing Among Women With Pathogenic Variants ...
Condition
Genetic Testing
Enrollment
806 pts
Location
United States
Sponsor
Memorial Sloan Kettering Cance
NCT07083583 N/A
Recruiting
Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited...
Condition
Bleeding Disorders
Enrollment
40 pts
Location
United States
Sponsor
Nicoletta C Machin
NCT05553041 EARLY_Phase 1
Recruiting
18F-Fluciclovine PET-MRI in High-grade Glioma
Condition
Glioma
Enrollment
30 pts
Location
United States
Sponsor
Children's Hospital of Philade
NCT07205718 Phase 1, Phase 2
Recruiting
A Study of TAK-188 in Adults With Advanced or Spreading Solid Tumors
Condition
Advanced or Metastatic Solid Tumors
Enrollment
273 pts
Location
United States
Sponsor
Takeda
NCT06682988 Phase 2
Recruiting
A Study to Assess Adverse Events and Change in Disease Activity in Participants ...
Condition
Advanced High-Grade Epithelial Ovarian Cancer
Enrollment
110 pts
Location
United States, Australia, Belgium
Sponsor
AbbVie
NCT07532603 Phase 2, Phase 3
Recruiting
A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris
Condition
Lichen Planopilaris
Enrollment
342 pts
Location
United States, Australia, Canada
Sponsor
Priovant Therapeutics, Inc.
NCT05223803 Phase 2
Recruiting
TERPS Trial for de Novo Oligometastic Prostate Cancer
Condition
Prostate Cancer
Enrollment
122 pts
Location
United States
Sponsor
University of Maryland, Baltim
NCT06693570 Phase 4
Recruiting
Evaluating Intact Fish Skin Graft and Standard of Care Versus Standard of Care A...
Condition
Venous Leg Ulcer (VLU)
Enrollment
150 pts
Location
United States
Sponsor
Kerecis Ltd.
NCT05734066 Phase 1, Phase 2
Recruiting
Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants Wit...
Condition
Refractory Ewing Sarcoma
Enrollment
60 pts
Location
United States, Canada
Sponsor
Jazz Pharmaceuticals
NCT04657822 Phase 4
Recruiting
Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior ...
Condition
Sickle Cell Disease
Enrollment
130 pts
Location
United States, Belgium, Brazil
Sponsor
Novartis Pharmaceuticals
NCT07768345 Phase 3
Recruiting
A Study to Learn About Revaccination With a Vaccine Called RSVpreF in Immunocomp...
Condition
Respiratory Syncytial Virus (RSV)
Enrollment
440 pts
Location
United States
Sponsor
Pfizer
NCT05916339 Phase 4
Recruiting
AWARE: Management of ADHD in Autism Spectrum Disorder
Condition
ADHD
Enrollment
500 pts
Location
United States, Canada
Sponsor
Daniel Coury
NCT07145801 Phase 2
Recruiting
Y-90 Treatment Response Using Transarterial Radioembolization
Condition
HCC
Enrollment
30 pts
Location
United States
Sponsor
Thomas Jefferson University
NCT05437575 Phase 3
Recruiting
Prehospital Analgesia INtervention Trial (PAIN)
Condition
Traumatic Injury
Enrollment
994 pts
Location
United States
Sponsor
Jason Sperry
NCT05885412 Phase 1
Recruiting
A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediat...
Condition
PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM)
Enrollment
9 pts
Location
United States
Sponsor
Rocket Pharmaceuticals Inc.
NCT04221542 Phase 1
Recruiting
Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate C...
Condition
Prostate Cancer
Enrollment
505 pts
Location
United States, Australia, China
Sponsor
Amgen
NCT04165070 Phase 1, Phase 2
Recruiting
KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) ...
Condition
Carcinoma, Non-Small-Cell Lung
Enrollment
450 pts
Location
United States, Canada, Hungary
Sponsor
Merck Sharp & Dohme LLC
NCT07064005 Phase 1
Recruiting
Enrichment of Glutathione Using Gamma-glutamylcysteine Supplementation in Parkin...
Condition
Parkinsons Disease (PD)
Enrollment
12 pts
Location
United States
Sponsor
Pravat Mandal
NCT07569029 Phase 1
Recruiting
A Trial to Evaluate the Safety and Tolerability of DV700P-RNA and DV701B1.1-RNA ...
Condition
HIV
Enrollment
42 pts
Location
United States, Argentina, Peru
Sponsor
National Institute of Allergy
NCT04889872 N/A
Recruiting
PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAV...
Condition
Aortic Stenosis, Calcific
Enrollment
2,250 pts
Location
United States, Australia, Canada
Sponsor
Edwards Lifesciences
NCT06636383 N/A
Recruiting
Glycogen Storage Disease Type Ia (GSDIa) Disease Monitoring Program
Condition
Glycogen Storage Disease Type Ia
Enrollment
140 pts
Location
United States, Brazil, Canada
Sponsor
Ultragenyx Pharmaceutical Inc
NCT06355895 N/A
Recruiting
Liver Volume Variation Effect on SBRT Planning and Delivery for Upper Abdominal ...
Condition
Upper Abdominal Malignancies
Enrollment
17 pts
Location
United States
Sponsor
University of Pittsburgh
NCT05599022 N/A
Recruiting
Randomized Assessment of TcMS for VT Storm
Condition
Ventricular Tachycardia
Enrollment
60 pts
Location
United States
Sponsor
University of Pennsylvania
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology