State IL
Clinical Trials in Illinois
Illinois is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Illinois and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 398 actively recruiting studies with Illinois sites out of 398 registered in total. The busiest research areas in Illinois are Schizophrenia, Obesity, Breast Cancer. Leading sponsors running trials in the state include University of Chicago, Northwestern University, University of Illinois Chicago. By stage, Illinois trials break down as Phase 1 (55), Phase 2 (104), Phase 3 (106), Phase 4 (15).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Illinois
Frequently Asked Questions — Clinical Trials in Illinois
How many clinical trials are currently recruiting in Illinois?
ClinicalMetric currently tracks 398 actively recruiting clinical trials with at least one location in Illinois. The total number of registered studies—including active but not currently enrolling trials—is 398. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Illinois?
Illinois hosts clinical trials across a broad range of medical conditions, including Schizophrenia, Obesity, Breast Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Illinois serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Illinois?
To join a clinical trial in Illinois, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Illinois maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Illinois
NCT06736574 Phase 3
Recruiting
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With S...
Condition
Heart Failure
Enrollment
1,800 pts
Location
United States, Canada, China
Sponsor
Cytokinetics
NCT04590690 N/A
Recruiting
Gut Microbiome and Sex as Risk Factors for Kidney Stones After Bariatric Surgery
Condition
Bariatric Surgery Candidate
Enrollment
28 pts
Location
United States
Sponsor
University of Chicago
NCT05786417 Phase 4
Recruiting
LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and...
Condition
Angina
Enrollment
741 pts
Location
United States
Sponsor
Yale University
NCT05299710 N/A
Recruiting
Ovarian Tissue Cryopreservation in Pre-Pubertal (OTC-Pre Pubertal)
Condition
Cancers
Enrollment
250 pts
Location
United States
Sponsor
Erin Rowell
NCT07477860 Phase 1
Recruiting
Achilles Tendinopathy Embolization
Condition
Achilles Tendinopathy (AT)
Enrollment
10 pts
Location
United States
Sponsor
Joint & Vascular Institute
NCT06413979 N/A
Recruiting
Family Support Protocol for Adolescent Internalizing Disorders
Condition
Internalizing Disorders
Enrollment
60 pts
Location
United States
Sponsor
The National Center on Addicti
NCT04055818 Phase 1
Recruiting
A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High...
Condition
Sickle Cell Disease
Enrollment
20 pts
Location
United States
Sponsor
EpiDestiny, Inc.
NCT07269210 Phase 2
Recruiting
A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceride...
Condition
Severe Hypertriglyceridemia
Enrollment
60 pts
Location
United States, Canada, China
Sponsor
Eli Lilly and Company
NCT07104825 N/A
Recruiting
Autonomic Neural Blockade in Bariatric Surgery
Condition
Bariatric Surgery Candidate
Enrollment
200 pts
Location
United States
Sponsor
Endeavor Health
NCT06008860 Phase 4
Recruiting
A Pilot Clinical Evaluation of Astepro® Nasal Spray for Management of Early SARS...
Condition
COVID-19
Enrollment
280 pts
Location
United States
Sponsor
University of Chicago
NCT07339423 Phase 3
Recruiting
AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps...
Condition
Obesity
Enrollment
1,150 pts
Location
United States, Argentina, Australia
Sponsor
Novo Nordisk A/S
NCT05443126 Phase 1, Phase 2
Recruiting
A Study of EP0031 (Lunbotinib) in Patients With Advanced RET-altered Malignancie...
Condition
NSCLC
Enrollment
265 pts
Location
United States, France, Germany
Sponsor
Ellipses Pharma
NCT06057935 Phase 2
Recruiting
A Study of Additional Chemotherapy After Surgery for People With Malignant Perit...
Condition
Malignant Peritoneal Mesothelioma
Enrollment
64 pts
Location
United States
Sponsor
Memorial Sloan Kettering Cance
NCT04372615 Phase 2
Recruiting
The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis
Condition
Autoimmune Encephalitis
Enrollment
116 pts
Location
United States, Netherlands, Spain
Sponsor
University of Utah
NCT06655376 Phase 4
Recruiting
Aspirin and Hemocompatibility Events in Chronic Advanced Heart Failure Patients ...
Condition
Bleeding
Enrollment
128 pts
Location
United States
Sponsor
Columbia University
NCT07145138 N/A
Recruiting
UIC Multi-Ethnic DCM Registry
Condition
Heart Failure
Enrollment
1,500 pts
Location
United States
Sponsor
University of Illinois Chicago
NCT07430917 Phase 2
Recruiting
Safety and Efficacy of J147 in Acute Ischemic Stroke
Condition
Acute Ischemic Stroke
Enrollment
196 pts
Location
United States
Sponsor
Abrexa Pharmaceuticals, Inc.
NCT05139017 Phase 2, Phase 3
Recruiting
A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care i...
Condition
DLBCL
Enrollment
290 pts
Location
United States, Argentina, Australia
Sponsor
Merck Sharp & Dohme LLC
NCT07140913 Phase 3
Recruiting
A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatmen...
Condition
Mania
Enrollment
424 pts
Location
United States, Argentina, Bulgaria
Sponsor
Bristol-Myers Squibb
NCT07629440 Phase 3
Recruiting
A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.
Condition
Pneumococcal Disease
Enrollment
3,230 pts
Location
United States, Japan, Puerto Rico
Sponsor
Pfizer
NCT06837220 N/A
Recruiting
Implementation of Tobacco Cessation Programming at Community Behavioral Health S...
Condition
Nicotine Use Disorder
Enrollment
24 pts
Location
United States
Sponsor
University of Chicago
NCT06996379 N/A
Recruiting
J-Tip Use for Paracentesis in Adults With Ascites
Condition
Evaluate Patient Comfort Level During Paracentesis by Numbing Skin With a Needle-less Device, Instead of Using a Needle to Numb the Skin
Enrollment
110 pts
Location
United States
Sponsor
Northwestern University
NCT05157282 N/A
Recruiting
Spinal Cord Stimulation for Functional Recovery in Humans With Tetraplegia
Condition
Spinal Cord Injury
Enrollment
86 pts
Location
United States
Sponsor
VA Office of Research and Deve
NCT06832189 Phase 1
Recruiting
EVR and EPO for Liver Transplant Tolerance
Condition
Liver Transplant
Enrollment
20 pts
Location
United States
Sponsor
National Institute of Allergy
NCT07089615 N/A
Recruiting
Prospective, Open-label, Non-significant Risk, Multicenter Study Comparing the P...
Condition
Colonic Polyps
Enrollment
330 pts
Location
United States
Sponsor
Capso Vision, Inc.
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology