State IL
Clinical Trials in Illinois
Illinois is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Illinois and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 406 actively recruiting studies with Illinois sites out of 406 registered in total. The busiest research areas in Illinois are Ovarian Cancer, Breast Cancer, Prostate Cancer. Leading sponsors running trials in the state include University of Chicago, Northwestern University, National Cancer Institute (NCI). By stage, Illinois trials break down as Phase 1 (66), Phase 2 (130), Phase 3 (103), Phase 4 (13).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Illinois
Frequently Asked Questions — Clinical Trials in Illinois
How many clinical trials are currently recruiting in Illinois?
ClinicalMetric currently tracks 406 actively recruiting clinical trials with at least one location in Illinois. The total number of registered studies—including active but not currently enrolling trials—is 406. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Illinois?
Illinois hosts clinical trials across a broad range of medical conditions, including Ovarian Cancer, Breast Cancer, Prostate Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Illinois serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Illinois?
To join a clinical trial in Illinois, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Illinois maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Illinois
NCT02432560 N/A
Recruiting
Safety and Durability of Sirolimus for Treatment of LAM
Condition
Lymphangioleiomyomatosis
Enrollment
600 pts
Location
United States
Sponsor
University of Cincinnati
NCT06469788 N/A
Recruiting
Testimonials and Navigation in Rheumatology
Condition
Rheumatologic Disease
Enrollment
1,170 pts
Location
United States
Sponsor
University of Alabama at Birmi
NCT03999983 N/A
Recruiting
Vertebral Artery Origin Treatment Via Endovascular Techniques Registry (VOTER)
Condition
Vertebral Artery Stenosis
Enrollment
150 pts
Location
United States
Sponsor
St. Louis University
NCT06049680 Phase 4
Recruiting
Safety Study of SMOFlipid to Evaluate the Risk of Developing EFAD and/or PNAC in...
Condition
Malnutrition, Child
Enrollment
100 pts
Location
United States
Sponsor
Fresenius Kabi
NCT07243652 N/A
Recruiting
I-DECIDE After Bronchiolitis Hospitalization
Condition
Bronchiolitis Acute
Enrollment
2,700 pts
Location
United States, Canada
Sponsor
Seattle Children's Hospital
NCT05806515 Phase 2
Recruiting
Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cance...
Condition
Prostate Adenocarcinoma
Enrollment
44 pts
Location
United States
Sponsor
SWOG Cancer Research Network
NCT06657976 Phase 2
Recruiting
Response to Exercise and Nitric Oxide in PAD
Condition
Peripheral Artery Disease
Enrollment
200 pts
Location
United States
Sponsor
Northwestern University
NCT07428538 Phase 3
Recruiting
Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With ...
Condition
Hepatitis
Enrollment
350 pts
Location
United States
Sponsor
Bausch Health Americas, Inc.
NCT02693535 Phase 2
Recruiting
TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That...
Condition
Lymphoma, Non-Hodgkin
Enrollment
4,200 pts
Location
United States, Puerto Rico
Sponsor
American Society of Clinical O
NCT06975865 Phase 3
Recruiting
The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years Wit...
Condition
Sickle Cell Disease
Enrollment
192 pts
Location
United States, Belgium, Brazil
Sponsor
Sanofi
NCT07059065 N/A
Recruiting
FIBERGRAFT Aeridyan Posterolateral Fusion Study
Condition
Degenerative Spine Disease
Enrollment
316 pts
Location
United States
Sponsor
DePuy Synthes Products, Inc.
NCT07219771 Phase 3
Recruiting
A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarth...
Condition
Knee Osteoarthritis
Enrollment
300 pts
Location
United States, Australia
Sponsor
Doron Therapeutics Inc.
NCT07845487 Phase 2
Recruiting
A Trial to Investigate PALI-2108 Versus Placebo in Participants With Moderately ...
Condition
Ulcerative Colitis (UC)
Enrollment
204 pts
Location
United States, Canada, Czechia
Sponsor
Palisade Bio
NCT07296484 Phase 2
Recruiting
Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)
Condition
Type 2 Diabetes
Enrollment
1,500 pts
Location
United States
Sponsor
Sparrow Pharmaceuticals
NCT06836232 Phase 2
Recruiting
An Open-Label Pilot Study of VTX2735 in Recurrent Pericarditis
Condition
Recurrent Pericarditis
Enrollment
50 pts
Location
United States, Belgium, Canada
Sponsor
Zomagen Biosciences Ltd.
NCT06925321 Phase 3
Recruiting
A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult P...
Condition
Invasive Mold Infections
Enrollment
234 pts
Location
United States, Australia, Austria
Sponsor
Basilea Pharmaceutica
NCT06783309 Phase 1, Phase 2
Recruiting
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Wit...
Condition
Type 1 Diabetes Mellitus
Enrollment
72 pts
Location
United States
Sponsor
COUR Pharmaceutical Developmen
NCT06538584 Phase 1, Phase 2
Recruiting
Dex +/- Caffeine Sedation in a Post-MRI Recovery in a Pediatric Population
Condition
Enhanced Recovery After Surgery in a Pediatric Population
Enrollment
100 pts
Location
United States
Sponsor
University of Chicago
NCT07408206 EARLY_Phase 1
Recruiting
Sleep, Dreaming, and Virtual Reality for Mental Health
Condition
Anxiety
Enrollment
70 pts
Location
United States
Sponsor
Northwestern University
NCT07477509 N/A
Recruiting
Northwestern Neuromuscular Disease Biorepository
Condition
Neuromuscular Diseases (NMD)
Enrollment
2,500 pts
Location
United States
Sponsor
Northwestern University
NCT07444814 Phase 1
Recruiting
Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Dr...
Condition
Endometrial Cancer
Enrollment
226 pts
Location
United States
Sponsor
Whitehawk Therapeutics, Inc.
NCT06401421 N/A
Recruiting
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Brea...
Condition
Breast Cancer
Enrollment
1,800 pts
Location
United States, Canada
Sponsor
Exact Sciences Corporation
NCT05419492 Phase 1, Phase 2
Recruiting
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Ch...
Condition
Dravet Syndrome
Enrollment
113 pts
Location
United States, Australia, United Kingdom
Sponsor
Encoded Therapeutics
NCT06568367 Phase 3
Recruiting
Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shif...
Condition
Excessive Sleepiness
Enrollment
520 pts
Location
United States, Canada
Sponsor
Axsome Therapeutics, Inc.
NCT07720271 Phase 3
Recruiting
AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People...
Condition
Overweight
Enrollment
950 pts
Location
United States
Sponsor
Novo Nordisk A/S
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology