Browse by Phase
Phase 3 Clinical Trials
Phase 3 trials compare a new drug or treatment against the current standard of care in a large population (300–3,000+ participants). Successful Phase 3 results are the basis for regulatory approval.
Total Trials
537
Recruiting Now
537
Top Conditions in Phase 3
Frequently Asked Questions — Phase 3 Trials
Why are Phase 3 trials the standard for drug approval?
Phase 3 trials compare a new treatment against the current standard of care in a large, randomized population of 300–3,000+ participants. This large-scale comparative evidence is what regulatory agencies—FDA, EMA—require to approve a new drug. A successful Phase 3 trial demonstrates that the new treatment is more effective, safer, or both compared to existing options in a statistically significant, reproducible way.
What is a placebo control in a Phase 3 trial?
Many Phase 3 trials use a placebo control—a group that receives an inactive substance—to isolate the true effect of the treatment. When an established standard of care exists, control-arm participants typically receive that treatment rather than a placebo, for ethical reasons. Blinded designs prevent participants and investigators from knowing who received which treatment, reducing bias in outcome assessment.
How do I find and join a Phase 3 clinical trial?
ClinicalMetric lists all Phase 3 trials registered on ClinicalTrials.gov. Each trial card shows recruitment status, enrollment target, sponsor, conditions studied, and site locations. To join a Phase 3 trial, review the eligibility criteria and contact the trial site directly—usually an academic medical center or hospital. Your physician can facilitate a referral to the appropriate study site.
Active Phase 3 Studies
NCT06947330 Phase 3
Recruiting
Comparison Between Erector Spinae Plane Block Versus Serratus Anterior Plane Blo...
Condition
Modified Radical Mastectomy
Enrollment
100 pts
Location
Egypt
Sponsor
Kholoud Usama
NCT07007312 Phase 3
Recruiting
Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With...
Condition
Acute Myeloid Leukemia (AML)
Enrollment
1,300 pts
Location
United States, Australia, Belgium
Sponsor
Kura Oncology, Inc.
NCT06244745 Phase 3
Recruiting
Effects of Letrozole During the Luteal Phase After Controlled Ovarian Stimulatio...
Condition
Luteinised Follicular Cyst
Enrollment
152 pts
Location
Spain
Sponsor
IVI Madrid
NCT07085767 Phase 3
Recruiting
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/...
Condition
Breast Cancer
Enrollment
1,000 pts
Location
United States, Australia, Austria
Sponsor
Olema Pharmaceuticals, Inc.
NCT05342792 Phase 3
Recruiting
Metronomic Capecitabine With or Without PD-1 Antibody as Adjuvant Therapy in Hig...
Condition
Nasopharyngeal Carcinoma
Enrollment
556 pts
Location
China
Sponsor
Sun Yat-sen University
NCT06755151 Phase 3
Recruiting
Fenofibrate in Primary Biliary Cholangitis: a Real World Study
Condition
Primary Biliary Cholangitis (PBC)
Enrollment
300 pts
Location
China
Sponsor
Xijing Hospital of Digestive D
NCT07444775 Phase 3
Recruiting
Lattice Radiation Therapy Versus Conventional Radiation Therapy for the Palliati...
Condition
Histopathologically or Cytologically Confirmed Solid Tumor Who Require Palliation Radiation Therapy to a Lesion ≥5cm
Enrollment
148 pts
Location
Canada
Sponsor
University Health Network, Tor
NCT05392764 Phase 3
Recruiting
Early Treatment With a Sodium-glucose Co-transporter 2 Inhibitor in High-risk Pa...
Condition
Acute Heart Failure
Enrollment
444 pts
Location
Japan
Sponsor
Juntendo University
NCT05954078 Phase 3
Recruiting
Circulating Tumor DNA Methylation Guided Postoperative Adjuvant Chemotherapy for...
Condition
High-risk Stage II Colorectal Cancer
Enrollment
340 pts
Location
China
Sponsor
Fudan University
NCT05401578 Phase 3
Recruiting
Canakinumab for the Treatment of Postprandial Hypoglycemia
Condition
Postprandial Hypoglycemia
Enrollment
56 pts
Location
Switzerland
Sponsor
University Hospital, Basel, Sw
NCT07842991 Phase 3
Recruiting
Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention o...
Condition
Plaque
Enrollment
120 pts
Location
Italy
Sponsor
Colgate Palmolive
NCT04435990 Phase 3
Recruiting
Efficacy and Safety Evaluation for the Treatment of Allergy Against Mites
Condition
Rhinitis, Allergic
Enrollment
150 pts
Location
Spain
Sponsor
Inmunotek S.L.
NCT07245238 Phase 3
Recruiting
Topical Cannabidiol Lotion for Pruritus Relief in Scleroderma
Condition
Mediciine
Enrollment
36 pts
Location
Thailand
Sponsor
Khon Kaen University
NCT03131726 Phase 3
Recruiting
Treatment of Graves´ophthalmopathy with Simvastatin (GO-S)
Condition
Graves Ophthalmopathy
Enrollment
80 pts
Location
Sweden
Sponsor
Lund University
NCT07050043 Phase 3
Recruiting
Low Dose Nivolumab With Chemotherapy vs Standard Chemotherapy as First-Line Trea...
Condition
NSCLC (Non-small Cell Lung Carcinoma)
Enrollment
123 pts
Location
Malaysia
Sponsor
Dr Arvindran A/L Alaga
NCT06525155 Phase 3
Recruiting
Effect GnRH Agonist Administration in Endometriosis Cyst Patients
Condition
Endometriosis
Enrollment
32 pts
Location
Indonesia
Sponsor
Rumah Sakit Pusat Angkatan Dar
NCT07573176 Phase 3
Recruiting
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Ma...
Condition
Depressive Disorder, Major
Enrollment
600 pts
Location
United States, Argentina, Brazil
Sponsor
Janssen Research & Development
NCT07297589 Phase 3
Recruiting
Epicardial Cardiac Fat-CT (EPIC-CT)
Condition
STEMI - ST Elevation Myocardial Infarction
Enrollment
136 pts
Location
Mexico
Sponsor
Instituto Mexicano del Seguro
NCT07169643 Phase 3
Recruiting
Darbepoetin in Patients Candidates for Liver Transplant. (EPO-LT Trial)
Condition
Liver Transplant; Complications
Enrollment
140 pts
Location
Spain
Sponsor
Fundacion Clinic per a la Rece
NCT06865417 Phase 3
Recruiting
A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulce...
Condition
Ulcerative Colitis
Enrollment
80 pts
Location
Belgium, Croatia, France
Sponsor
Alfasigma S.p.A.
NCT06387290 Phase 3
Recruiting
Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits
Condition
Chronic Pain
Enrollment
300 pts
Location
United States
Sponsor
University of Utah
NCT07326540 Phase 3
Recruiting
Efficacy and Safety of BV100 Plus Low Dose Polymyxin B Versus Colistin Plus High...
Condition
Hospital Acquired Bacterial Pneumonia (HABP)
Enrollment
248 pts
Location
Georgia
Sponsor
BioVersys SAS
NCT06693674 Phase 3
Recruiting
Effect of Sacubitril-Valsartan on Cardiac Structure and Function
Condition
Congenital Heart Disease
Enrollment
45 pts
Location
United States
Sponsor
Mayo Clinic
NCT06846450 Phase 3
Recruiting
Phase 3 Trial Comparing IMRT or IMPT Plus CIRT for Patients With NPC
Condition
Nasopharyngeal Cancinoma (NPC)
Enrollment
470 pts
Location
China
Sponsor
Lin Kong, MD
NCT06926829 Phase 3
Recruiting
A Long-term Trial of EB-1020 in Adult Patients With ADHD
Condition
Attention Deficit Hyperactivity Disorder (ADHD)
Enrollment
180 pts
Location
Japan
Sponsor
Otsuka Pharmaceutical Co., Ltd
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology