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postoperative pain

Total Trials

26

Recruiting Now

26

Trial Phases

Phase 2, Phase 2, Phase 3, Phase 4

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain β€” each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — postoperative pain Clinical Trials

How many clinical trials are currently recruiting for postoperative pain?

ClinicalMetric currently tracks 26 actively recruiting clinical trials for postoperative pain, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 26. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for postoperative pain?

postoperative pain research spans Phase 2 (3 trials), Phase 3 (1 trial), Phase 4 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a postoperative pain clinical trial?

Eligibility criteria for postoperative pain trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 2

3

Phase 3

1

Phase 4

3

Top Sponsors

Ondokuz Mayıs University 2 trials

Ferit Yetik 2 trials

Istanbul University - Cerrahpasa 1 trial

University of Sao Paulo 1 trial

Sakarya University 1 trial

Recruiting Clinical Trials

The Effect of Virtual Reality and Eye Mask During Dressing After CABG Surgery

Turkey (Türkiye)

Istanbul University - Cerrahpa...

Intraoperative Cryoanalgesia Versus Thoracic Epidural Block in MIRPE (Minimally Invasive Repair of Pectus Excavatum)

University of Sao Paulo

Serratus Posterior Superior vs Erector Spinae Plane Block for Breast Surgery

Turkey (Türkiye)

Sakarya University

Pectoral Nerve Block Versus Serratus Posterior Superior Intercostal Plane Block for Pain Control After Mastectomy

Turkey (Türkiye)

Bursa City Hospital

NCT07399860 Phase 2

Botulinum Toxin A Before Hemorrhoidectomy to Prevent Postoperative Pain

Lomonosov Moscow State Univers...

Modified External Oblique Intercostal Plane Block Versus Erector Spinae Plane Block for Open Nephrectomy

Turkey (Türkiye)

Namik Kemal University

Lateral QL Block vs Intrathecal Morphine for Cesarean Section

Turkey (Türkiye)

Ondokuz Mayıs University

Determining the Optimal Dose of Intrathecal Morphine for Post-Cesarean Analgesia

University of Ioannina

Comparative Analysis of the Impact of Transversus Abdominis Plane Block on Post-Cesarean Pain Management Using Low Concentration Ropivacaine 0,2%

Matild Keresztes

Feasibility of Breathwork Intervention With Older Adults After Knee Surgery

University of Arizona

RISS Versus SPSIP Block in Modified Radical Mastectomy

Turkey (Türkiye)

A Clinical Follow-up Study on the Efficacy of Thumbtack Needle for Postoperative Sleep and Recovery Treatment

The First Affiliated Hospital ...

NCT06996561 Phase 2, Phase 3

Exploring the Impact of Genetic Variations on The Clinical Efficacy of Nalbuphine in Postoperative Pain Management

Dr. Asma Abdus Salam

NCT07073846 Phase 4

Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery.

Instituto Mexicano del Seguro ...

SPSIP Versus RISS Block in Volume-Preserving VATS

Turkey (Türkiye)

Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery

Massachusetts General Hospital

Erector Spinae Plane Block and Low-Flow Anaesthesia in Laparoscopic Cholecystectomy

Turkey (Türkiye)

Taksim Egitim ve Arastirma Has...

NCT07188779 Phase 2

Impact of RADA16 Use on Outcomes Following Tonsillectomy in Children

Rutgers, The State University ...

Efficacy of Liposomal Bupivacaine for Transversus Abdominis Plane Block

Tianjin First Central Hospital

NCT07353996 Phase 4

Determination of the Effective Dose of a Single Intravenous Dose of Tegileridine Fumarate for Postoperative Analgesia After Orthopedic Surgery: A Up-and-Down Sequential Allocation Study

Second Affiliated Hospital, Zh...

FRONT Block for Quality of Recovery After Total Hip Arthroplasty

Turkey (Türkiye)

Konya Meram State Hospital

Different Hemostatic Agents Used in Partial Pulpotomy on Pulp Survival and Postoperative Pain

Turkey (Türkiye)

Cukurova University

NCT06479122 Phase 4

Efficacy of Acetaminophen Alone Versus Combination of Acetaminophen/Ibuprofen After Cesarean Section

Seoul National University Hosp...

Breathing Interventions for Postoperative Breast Surgery Patients

Turkey (Türkiye)

Ondokuz Mayıs University

SPSIP Block Versus ESP Block for Chronic Pain After Unilateral Breast Surgery

Turkey (Türkiye)

Combined Popliteal and Adductor Canal Blocks for Postoperative Analgesia in Children With Cerebral Palsy

Turkey (Türkiye)

Diskapi Yildirim Beyazit Educa...

Related Conditions

breast cancer (3) postoperative anxiety (2) cesarean section (2) opioid use (2) cabg (1) physiological parameter (1) coronary artery disease (1) funnel chest (1) pectus excavatum (1) postoperative pain after video assisted thoracic surgery (1) persistent postsurgical pain (1) hemorrhoids (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology