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postoperative pain

Total Trials

27

Recruiting Now

27

Trial Phases

Phase 4, Phase 3

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain β€” each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — postoperative pain Clinical Trials

How many clinical trials are currently recruiting for postoperative pain?

ClinicalMetric currently tracks 27 actively recruiting clinical trials for postoperative pain, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 27. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for postoperative pain?

postoperative pain research spans Phase 3 (1 trial), Phase 4 (5 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a postoperative pain clinical trial?

Eligibility criteria for postoperative pain trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 3

1

Phase 4

5

Top Sponsors

HASSAN 1st university 1 trial

Aydin Adnan Menderes University 1 trial

Hospital HM Nou Delfos 1 trial

Hitit University 1 trial

Cukurova University 1 trial

Recruiting Clinical Trials

Effect of Clinical Hypnosis in Preoperative Anxiety Among Patients Undergoing an Abdominal Surgery.

HASSAN 1st university

Effect of Bilateral Rhomboid Intercostal Block on Postoperative Pain After Breast Implant Surgery

Turkey (Türkiye)

Aydin Adnan Menderes Universit...

Modulation of the Inflammatory Response in Bariatric Surgery

Hospital HM Nou Delfos

Comparing ACB+IPACK and ACB+BiFeS Block Combinations for Analgesia in Total Knee Arthroplasty

Turkey (Türkiye)

Hitit University

Regional Analgesia Techniques for Laparoscopic Cholecystectomy

Turkey (Türkiye)

Cukurova University

The Effect of Superficial Parasternal Intercostal Plane Block on Pulmonary Function Tests After Cardiac Surgery

Pain Control After Aortic EndoaneurYsmEctomy (POPEYE)

IRCCS Policlinico S. Donato

US Guided EOI Block Versus ESPB for Postoperative Analgesia in Laparoscopic Cholecystectomy

Assiut University

Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management

Turkey (Türkiye)

Ataturk University

NCT06320041 Phase 4

Efficacy and Safety of Oliceridine for Moderate to Severe Acute Pain After Orthopedic Surgery

The Fourth Affiliated Hospital...

NCT07022821 Phase 4

Comparison of Dexmedetomidine + Ketamine for Postoperative Pain in C-Section

Fatima Memorial Hospital

NCT04894864 Phase 4

Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair

University of Crete

Efficacy of Liposomal Bupivacaine for Transversus Abdominis Plane Block

Tianjin First Central Hospital

NCT07413055 Phase 3

Comparative Efficacy Of 4 mg VS. 8 mg Submucosal Dexamethasone In Postoperative Pain Management After Dental Implant Surgery: A Randomized Double-Blind Controlled Clinical Trial

Oman Ministry of Health

Relationship Between Fracture Type and Preoperative Nutritional Status with Postoperative Pain

Turkey (Türkiye)

Ankara Ataturk Sanatorium Trai...

Sacral ESPB vs. PENG Block for Hip Hemiarthroplasty Analgesia

Fayoum University Hospital

Sex Hormones, Postoperative Pain and Opioid Use

Washington University School o...

Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery

Tanta University

SPSIP Versus RISS Block in Volume-Preserving VATS

Turkey (Türkiye)

Dexmedetomidine as an Adjuvant to Bupivacaine in Scalp Block Versus Bupivacaine Alone for Postoperative Pain Management in Patients Undergoing Craniotomy

Ain Shams University

NCT05804591 Phase 4

Pregabalin in the Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy (LSG).

Medical University of Warsaw

Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar Extraction

Turkey (Türkiye)

Harran University

Effect of Rotary File Number on MB2 Canal Negotiation and Postoperative Pain

Turkey (Türkiye)

Mehmet Adıgüzel

NCT06903819 Phase 4

Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

Texas Tech University Health S...

Preoperative Sleep Quality and Postoperative Outcomes in Breast Surgery

Turkey (Türkiye)

Dr Abdurrahman Yurtaslan Ankar...

PARO-agitation-study

Hannover Medical School

Opioid Prescribing Practices in Laparoscopic Gynecologic Surgery

University of Tennessee

Related Conditions

opioid use (5) obesity (2) inflammation (2) hypnosis (1) preoperative anxiety (1) abdominal surgeries (1) length of stay (1) breast prosthesis pain (1) breast augmentation (1) bariatric surgery candidate (1) opioid free anesthesia (1) heart rate variability (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology