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postoperative pain

Total Trials

25

Recruiting Now

25

Trial Phases

Phase 2, Phase 3, Phase 2, Phase 3

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain β€” each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — postoperative pain Clinical Trials

How many clinical trials are currently recruiting for postoperative pain?

ClinicalMetric currently tracks 25 actively recruiting clinical trials for postoperative pain, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 25. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for postoperative pain?

postoperative pain research spans Phase 1 (1 trial), Phase 2 (3 trials), Phase 3 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a postoperative pain clinical trial?

Eligibility criteria for postoperative pain trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

1

Phase 2

3

Phase 3

2

Top Sponsors

Konya City Hospital 2 trials

Medipol University 2 trials

CHU de Quebec-Universite Laval 1 trial

Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital 1 trial

Shanghai Huilun Pharmaceutical Co., Ltd. 1 trial

Recruiting Clinical Trials

Fentanyl vs. Remifentanil in Laparoscopic Cholecystectomy: Effects on Bowel Function and Pain

Turkey (Türkiye)

Konya City Hospital

Paravertebral Block for Mastectomy With Immediate Reconstruction

CHU de Quebec-Universite Laval

Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardiac Surgery

Turkey (Türkiye)

Saglik Bilimleri Universitesi ...

QIPB in Inguinal Hernia

Turkey (Türkiye)

Konya City Hospital

NCT07709598 Phase 2, Phase 3

Evaluate the Safety and Efficacy of HL-1186 Tablet for Postoperative Analgesia in Abdominal Surgery

Shanghai Huilun Pharmaceutical...

NCT05193227 Phase 2

Sustained Release Lidocaine for the Treatment of Postoperative Pain

University of British Columbia

Cryotherapy Versus Standard Care in Reducing Opioid Consumption After Total Knee Arthroplasty

Hospital Italiano de Buenos Ai...

PVI vs ESP Block for Reducing Bleeding and Postoperative Pain in Lumbar Fusion Surgery.

Fundació Institut de Recerca d...

TENS for Anxiety, Pain, and Satisfaction After Laparoscopic Cholecystectomy

Turkey (Türkiye)

Nigde Omer Halisdemir Universi...

NCT07060495 Phase 3

RADA16 for Adult Tonsillectomy

Rutgers, The State University ...

Characterization of Acute Pain

Children's National Research I...

Effects of Erector Spinae Plane Block on Opioid Consumption, Anesthetic Consumption and Hemodynamics in Lumbar Disc Herniation Surgeries.

Turkey (Türkiye)

Ankara Ataturk Sanatorium Trai...

Bilateral Ultrasound Guided Intramuscular Quadratus Lumborum Plane Block Versus Bilateral Lateral Quadratus Lumborum Plane Block in Controlling Postoperative Pain in Cancer Patients Undergoing Open Nephrectomy

National Cancer Institute, Egy...

Different Hemostatic Agents Used in Partial Pulpotomy on Pulp Survival and Postoperative Pain

Turkey (Türkiye)

Cukurova University

Reducing Opioid Use for Chronic Pain Patients Following Surgery

University Health Network, Tor...

Postoperative Nausea, Vomiting and Pain After Bariatric Surgery - a National Registry Study

Umeå University

The Effect of Intravenous Dexketoprofen on the Severity and Incidence of Rebound Pain

Turkey (Türkiye)

Eskisehir Osmangazi University

Efficacy of Ultrasound-Guided Erector Spinae Block for Postoperative Pain Management in Nephrectomy

Bangladesh Medical University

Deep Subgluteal Block vs PENG Combined With LFCN Block for Analgesia After Hip Arthroplasty

Turkey (Türkiye)

Medipol University

Preventive Analgesia With Anrikefon in Laparoscopic Cholecystectomy

Xuanwu Hospital, Beijing

NCT07399860 Phase 2

Botulinum Toxin A Before Hemorrhoidectomy to Prevent Postoperative Pain

Lomonosov Moscow State Univers...

Sacral ESPB vs. PENG Block for Hip Hemiarthroplasty Analgesia

Fayoum University Hospital

Effect of Acupressure on Postoperative Pain After Laparoscopic Totally Extraperitoneal Inguinal Hernia Repair

Turkey (Türkiye)

Medipol University

NCT07519109 Phase 1

Study Evaluating the Safety, Efficacy and Pharmacokinetics of SYH9089 Injection in Patients Undergoing Abdominal Surgery.

CSPC Ouyi Pharmaceutical Co., ...

QL Block Versus EO Plane Block for Analgesia After Open Nephrectomy

Cairo University

Related Conditions

postoperative bowel function (1) heart valve disease (1) postsurgical pain (1) osteoarthritis knee (1) total knee arthroplasty (1) surgical blood loss (1) lumbar spinal fusion surgery (1) gallstone disease (1) surgical anxiety (1) patient satisfaction after laparoscopic cholecystectomy (1) acute pain postoperative (1) acute pain (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology