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Medical Condition

chronic pain

Total Trials

29

Recruiting Now

29

Trial Phases

Phase 3, Phase 2, Phase 4

Chronic pain research has gained urgency given the limitations of opioid therapy and the search for non-addictive alternatives. Nav1.7 and Nav1.8 sodium channel blockers, CGRP antagonists (extended from migraine to other pain conditions), and neuromodulation approaches represent the most active mechanistic targets in current trials.

Trials investigate suzetrigine (Nav1.8 blocker), ziconotide intrathecal delivery, spinal cord stimulation with novel waveforms (burst, high-frequency), ketamine infusion protocols, low-dose naltrexone, and psychedelic-assisted pain management. Digital pain measurement tools and PROMIS scales are increasingly validated as primary endpoints.

Frequently Asked Questions — chronic pain Clinical Trials

How many clinical trials are currently recruiting for chronic pain?

ClinicalMetric currently tracks 29 actively recruiting clinical trials for chronic pain, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 29. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for chronic pain?

chronic pain research spans Phase 2 (1 trial), Phase 3 (2 trials), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a chronic pain clinical trial?

Eligibility criteria for chronic pain trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 2

1

Phase 3

2

Phase 4

1

Top Sponsors

Skane University Hospital 2 trials

University Hospital, Brest 2 trials

Brooke Army Medical Center 1 trial

Salem Anaesthesia Pain Clinic 1 trial

Edward Via Virginia College of Osteopathic Medicine 1 trial

Recruiting Clinical Trials

The PROmoting Pain Self-Management (PROs) Trial: Holistic Pain Care in the Military Health System

Brooke Army Medical Center

Lemborexant vs Zopiclone vs Clonidine for Insomnia Treatment in Chronic Pain Patients

Salem Anaesthesia Pain Clinic

VCOM Pain Free Research Collaborative

Edward Via Virginia College of...

Evaluating the Acceptability, Feasibility and Usability of Various Conversational Data Collection Software

AugMend Health Inc.

Keeping it Simple Study (KISS)

NCT06027099 Phase 3

CARES (Comprehensive Analgesic, Recovery, and Education Support) for Surgery Trial

Stanford University

iACT for PTSD and Chronic Pain

Skane University Hospital

Improving Health for Older Adults With Pain Through Engagement

Massachusetts General Hospital

Consensus-Based vs. Standardized Physiotherapy for Fibromyalgia

Al Hayah University In Cairo

SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease

University of Nebraska

Neuronal Activation Accuracy in Closed-loop Spinal Cord Stimulation

Dance-therapy and Chronic Pain

Hospices Civils de Lyon

Whole-Body Photobiomodulation and Chronic Pain Trial

Sandwell & West Birmingham Hos...

Erector Spinae Block Versus Paravertebral Block on Chronic Pain After Mastectomy

American University of Beirut ...

Online Yoga vs Acceptance and Commitment Therapy for Treating Chronic Musculoskeletal Pain

Palo Alto Veterans Institute f...

Internet-Delivered Acceptance and Commitment Therapy (iACT) for Youth With PTSD and Chronic Pain

Skane University Hospital

Hyperbaric Oxygen Therapy in Complex Regional Pain Syndrome

University Hospital Ostrava

NCT05285683 Phase 2

The Role of Brain Dopamine in Chronic Pain

University of Rochester

Reducing Opioid Use for Chronic Pain Patients Following Surgery

University Health Network, Tor...

Turkish Validation of the Geriatric Pain Measure - Short Form

Turkey (Türkiye)

Başakşehir Çam & Sakura City H...

Mindfulness-based Rehabilitation in a University Museum Setting to Reduce Pain and Improve Quality of Life in Women With Fibromyalgia: a Randomized Controlled Trial

G. d'Annunzio University

Pain Acceptance Training in Patients Experiencing Emotional Distress and Somatic Symptoms: Examination of Dialectical Thinking as a Mediating Factor

University of Haifa

Individual Differences in Gait and Osteoarthritis Pain

University of Pittsburgh

Impact of 4PCP on Practitioner and Patient Outcomes

Virginia Commonwealth Universi...

Emotional Intelligence and Chronic Orofacial Pain

University Hospital, Brest

A Bionic Breast Project Using Neuroprosthesis to Reduce Chronic Pain After Mastectomy

University of Chicago

NCT06395428 Phase 4

Haloperidol for Pain Control in Patients With Acute Musculoskeletal Back Pain in the Emergency Department

Western Michigan University Sc...

Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial

University of New Mexico

NCT05997979 Phase 3

Analgesic Effectiveness of Capsaicin 8% Cutaneous Patch in Children

University Hospital, Brest

Related Conditions

musculoskeletal pain (5) back pain (2) opioid misuse (2) ptsd (2) fibromyalgia (2) neuropathic pain (2) opioid use (2) musculoskeletal pain disorder (1) chronic insomnia (1) mental health disorders (1) behavioral health challenges (1) ecological momentary assessment best practices (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology