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Medical Condition

chronic pain

Total Trials

45

Recruiting Now

45

Trial Phases

Phase 3, Phase 2, Phase 1

Chronic pain research has gained urgency given the limitations of opioid therapy and the search for non-addictive alternatives. Nav1.7 and Nav1.8 sodium channel blockers, CGRP antagonists (extended from migraine to other pain conditions), and neuromodulation approaches represent the most active mechanistic targets in current trials.

Trials investigate suzetrigine (Nav1.8 blocker), ziconotide intrathecal delivery, spinal cord stimulation with novel waveforms (burst, high-frequency), ketamine infusion protocols, low-dose naltrexone, and psychedelic-assisted pain management. Digital pain measurement tools and PROMIS scales are increasingly validated as primary endpoints.

Frequently Asked Questions — chronic pain Clinical Trials

How many clinical trials are currently recruiting for chronic pain?

ClinicalMetric currently tracks 45 actively recruiting clinical trials for chronic pain, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 45. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for chronic pain?

chronic pain research spans Phase 1 (1 trial), Phase 2 (1 trial), Phase 3 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a chronic pain clinical trial?

Eligibility criteria for chronic pain trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

1

Phase 2

1

Phase 3

1

Top Sponsors

Weill Medical College of Cornell University 2 trials

University of Washington 2 trials

University Health Network, Toronto 2 trials

University of Minnesota 2 trials

VA Office of Research and Development 2 trials

Recruiting Clinical Trials

Development of a Healthcare Service Platform for Successful Aging

Effects of Low Back Pain Types on Pain Severity and Quality of Life in Patients With Failed Back Surgery Syndrome

Turkey (Türkiye)

Konya Beyhekim Training and Re...

Novel Stimulation Patterns to Improve the Effectiveness of Spinal Cord Stimulation

Ashwin Viswanathan

Evaluating a Virtual Stepped Care Portal in Youth Awaiting Tertiary Chronic Pain Care: An Implementation-Effectiveness Hybrid Type III Study

The Hospital for Sick Children

The PROACTIVE Study for Black Elders

University of Florida

Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome

Spaulding Rehabilitation Hospi...

Music Intervention in Chronic Pain Patients

Laval University

NCT06387290 Phase 3

Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits

University of Utah

POP SINGER Randomized Clinical Trial

University Hospitals Cleveland...

EXpain Trial - Exercise an a Non-pharmacological Pain-relieving Treatment in People With Multiple Sclerosis

University of Aarhus

Our Whole Lives Gemini: Virtual Integrative Medical Group Visits for Managing Chronic Pain

Cambridge Health Alliance

Modulation of Cortical Brain Activity During Attentional Control

National Council of Scientific...

Brief Mindfulness-Oriented Recovery Enhancement vs Brief Cognitive-Behavioral Therapy for Chronic Pain

Florida State University

A Community Health Worker-Led Program for Chronic Pain and Loneliness in Older Adults

Weill Medical College of Corne...

Mechanisms of Mindfulness Meditation and Self-Hypnosis for Pain in Older Adults With Chronic Pain

University of Washington

NCT06123715 Phase 2

Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty

University Health Network, Tor...

Individual Differences in Gait and Osteoarthritis Pain

University of Pittsburgh

Post Market Evaluation of Real World Outcomes and Durability to Support Implantable Inceptiv™ Spinal Cord Stimulation Therapy

United States, Belgi...

Prospective Assessment of Integrative Therapies for Neuromusculoskeletal Pain (PAIN)

Co-Adaptation of an Digital Pain Management Program for Canadian Veterans

University Health Network, Tor...

Consensus-Based vs. Standardized Physiotherapy for Fibromyalgia

Al Hayah University In Cairo

Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain

Washington University School o...

CIH Stepped Care for Co-occurring Chronic Pain and PTSD

University of Washington

Music as an Adjunct to Ketamine Therapy for Chronic Pain

McGill University

Effectiveness and Implementation of a Digital Intervention for Pediatric Chronic Pain Co-designed With Patients

University of Malaga

Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator

United States, Austr...

Abbott Medical Devices

Personalized High-Definition tDCS Protocols for Chronic Pain Treatment

Istituti Clinici Scientifici M...

Virtual Reality Rehabilitation in Neck Pain Subjects

IRCCS San Raffaele

SCENAR Therapy in Chronic Non-specific Neck Pain

The Teaspoon Study - Telefitting Spinal Cord Stimulation for Pain

University of Minnesota

Reducing Chronic Pain Following Cesarean Delivery

Stanford University

Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)

Attikon Hospital

Turkish Validation of the Geriatric Pain Measure - Short Form

Turkey (Türkiye)

Başakşehir Çam & Sakura City H...

Optimization of NIBS for Treatment of Addiction

Case Western Reserve Universit...

Interoceptive Awareness and Function in Adolescents With Chronic Pain

Connecticut Children's Medical...

Improving Spinal Cord Stimulation With ECAPS

University of Minnesota

NCT05925036 Phase 1

Novel Cellular Therapy for the Treatment of Pain Associated With Chronic Pancreatitis

VA Office of Research and Deve...

RCT of a Weighted Blanket to Reduce Pain in Veterans With Chronic Pain

VA Office of Research and Deve...

Integrated PTSD and Chronic Pain Treatment

Weill Medical College of Corne...

Validating and Evaluating the Pain Medicine Digital Workflow Algorithm (PGS 1.0)

PG Medical Systems Ltd.

Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort

Korea University

Scrambler Therapy in Chronic Pancreatitis

Johns Hopkins University

Different Treatments in Chronic Pain Patients.

University Ghent

VCOM Pain Free Research Collaborative

Edward Via Virginia College of...

The Post-ICU Pain Study

Zealand University Hospital

Related Conditions

neuropathic pain (2) pain chronic (2) fibromyalgia (2) neck pain (2) chronic pancreatitis (2) depression in old age (1) sleep disorder insomnia chronic (1) failed back surgery syndrome (1) pain neuropathic (1) musculoskeletal pain (1) osteoarthritis (1) movement evoked pain (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology