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Medical Condition

chronic pain

Total Trials

40

Recruiting Now

40

Trial Phases

Phase 2, Phase 4

Chronic pain research has gained urgency given the limitations of opioid therapy and the search for non-addictive alternatives. Nav1.7 and Nav1.8 sodium channel blockers, CGRP antagonists (extended from migraine to other pain conditions), and neuromodulation approaches represent the most active mechanistic targets in current trials.

Trials investigate suzetrigine (Nav1.8 blocker), ziconotide intrathecal delivery, spinal cord stimulation with novel waveforms (burst, high-frequency), ketamine infusion protocols, low-dose naltrexone, and psychedelic-assisted pain management. Digital pain measurement tools and PROMIS scales are increasingly validated as primary endpoints.

Frequently Asked Questions — chronic pain Clinical Trials

How many clinical trials are currently recruiting for chronic pain?

ClinicalMetric currently tracks 40 actively recruiting clinical trials for chronic pain, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 40. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for chronic pain?

chronic pain research spans Phase 2 (4 trials), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a chronic pain clinical trial?

Eligibility criteria for chronic pain trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 2

4

Phase 4

1

Top Sponsors

RIVER Foundation 2 trials

Duke University 2 trials

Ashwin Viswanathan 1 trial

The University of Texas Health Science Center, Houston 1 trial

Evon Medics LLC 1 trial

Recruiting Clinical Trials

Novel Stimulation Patterns to Improve the Effectiveness of Spinal Cord Stimulation

Ashwin Viswanathan

Ketamine Treatment Plans for Chronic Conditions

RIVER Foundation

Neuromodulation + Prolonged Exposure Therapy: Evaluation of a Technology-Enhanced, Integrated Treatment for Pain and PTSD

The University of Texas Health...

NCT06671132 Phase 2

Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment of Pain (CBOT-P)

Evon Medics LLC

PREVAIL Interdisciplinary Track: A Pragmatic Randomized Clinical Trial

Salem Veterans Affairs Medical...

Predictors of Pain in Sickle Cell Disease

Duke University

NCT04939623 Phase 2

Novel Use of Probenecid to Alleviate Symptoms of Opioid Withdrawal

University of Calgary

The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature

Faith A. Richardson

Evaluating a Virtual Stepped Care Portal in Youth Awaiting Tertiary Chronic Pain Care: An Implementation-Effectiveness Hybrid Type III Study

The Hospital for Sick Children

Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control

Boston Scientific Corporation

The Effectiveness of Ultra-Sound Guided Erector Spinae Block With Betamethasone for Management of Truncal Chronic Post Herpetic Neuralgia.

Cairo University

A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children

United States, Austr...

Telethon Kids Institute

Evaluation of Central Sensitization, Fear-Avoidance, and Pain-Pressure Threshold With Chronic Pain After Hysterectomy

KK Women's and Children's Hosp...

DEterminants of Decisional Autonomy In Chronic Pain Patients and Assessment of Treatment Effectiveness

Fondation Hôpital Saint-Joseph

Turkish Validation of the Geriatric Pain Measure - Short Form

Turkey (Türkiye)

Başakşehir Çam & Sakura City H...

Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy

Hugo W. Moser Research Institu...

Reducing Opioid Use for Chronic Pain Patients Following Surgery

University Health Network, Tor...

Validating and Evaluating the Pain Medicine Digital Workflow Algorithm (PGS 1.0)

PG Medical Systems Ltd.

Pain Management Teams Using Whole Health to Optimize Function and Safety in Veterans: The TEAMWORK Trial

VA Office of Research and Deve...

Observational Study of the Use of 8% Capsaicin Patch in Children 0 to 18 Years Old

University Hospital, Brest

Opioid Adherence and Support Through Innovative Texting Strategies

University of New Mexico

Impact of QoLibri Medical Device on the Consequences of Chronic Pain: a Randomized Controlled Trial

fMRI in Deep Brain Stimulation

Universitaire Ziekenhuizen KU ...

Impact of 4PCP on Practitioner and Patient Outcomes

Virginia Commonwealth Universi...

Lemborexant vs Zopiclone vs Clonidine for Insomnia Treatment in Chronic Pain Patients

Salem Anaesthesia Pain Clinic

IMPOWR-ME Project 1: Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs

Albert Einstein College of Med...

NCT06544291 Phase 2

Combined THC and CBD for OUD and Chronic Pain

Yale University

Online Yoga vs Acceptance and Commitment Therapy for Treating Chronic Musculoskeletal Pain

Palo Alto Veterans Institute f...

NCT04427709 Phase 2

Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity

Wake Forest University Health ...

Mindfulness-based Rehabilitation in a University Museum Setting to Reduce Pain and Improve Quality of Life in Women With Fibromyalgia: a Randomized Controlled Trial

G. d'Annunzio University

Can Medical Cannabis Affect Opioid Use?

Thomas Jefferson University

RIVER At Home Ketamine Protocols

RIVER Foundation

Novel Treatment Delivery of ECAP-controlled Closed-loop SCS for Chronic Pain

Saluda Medical Pty Ltd

eVISualisation of Physical Activity and Pain (eVIS) for Patients With Chronic Pain

Dalarna University

Pectoral Nerve Block Versus Paravertebral Block In The Incidence of Chronic Pain After Breast Cancer Surgery

Assiut University

Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain

Duke University

NCT05761015 Phase 4

Helping Osteoarthritis Patients to Walk With NSAID

University Hospital, Clermont-...

Mindfulness-Based Ecological Momentary Intervention for Opioid Use Disorder and Chronic Pain

Arizona State University

Brief Mindfulness-Oriented Recovery Enhancement vs Brief Cognitive-Behavioral Therapy for Chronic Pain

Florida State University

Neuronal Activation Accuracy in Closed-loop Spinal Cord Stimulation

Related Conditions

neuropathic pain (3) opioid use disorder (3) anxiety disorders (2) chronic disease (2) low back pain (2) fibromyalgia (2) musculoskeletal pain (2) osteoarthritis knee (2) pain neuropathic (1) depressive disorder (1) post traumatic stress disorder ptsd (1) sickle cell disease (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: July 2026 · Data Methodology