NCT07308873 Individual Differences in Gait and Osteoarthritis Pain
| NCT ID | NCT07308873 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Pittsburgh |
| Condition | Knee Osteoarthritis (OA) |
| Study Type | OBSERVATIONAL |
| Enrollment | 300 participants |
| Start Date | 2026-01-07 |
| Primary Completion | 2030-08-01 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 300 participants in total. It began in 2026-01-07 with a primary completion date of 2030-08-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this observational study is to look at inter-individual differences in knee osteoarthritis (OA) walking pain and performance. The main questions this study aims to answer are: Why do some people with knee osteoarthritis have more severe disabling pain than others, even though the degenerative changes in their knees are similar? What are the factors that contribute to walking pain in people with knee osteoarthritis? Participants will complete surveys, perform physical function tasks, get a knee X-ray and MRI, undergo non-invasive brain imaging, and undergo sensory testing.
Eligibility Criteria
Inclusion Criteria: * Knee pain for greater than 6 months. * Moderate-to-severe knee pain (\>3/10) due to osteoarthritis, as defined by American College of Rheumatology and EULAR diagnostic criteria, on \>50% of days in the past month. * KL grade 2-4 indicating significant degenerative changes on knee X-ray. * 45-80 years old Exclusion Criteria: * Inflammatory arthritis (e.g. rheumatoid arthritis). * More intense pain due to another chronic pain syndrome (e.g. fibromyalgia, hip osteoarthritis) * Significant pain or weakness in the lower extremities due to a neurological condition (e.g. lumbar radiculopathy, paresis due to stroke) * Acute pain that is more intense than knee osteoarthritis pain * Current routine use of more than 15 mg oral morphine equivalents per day (use of \<15 mg OME does not exclude the participant). * Recent new medication, exercise, behavioral, or complementary and integrative treatment started in the last month. Stable use of these treatments for greater than 1 month does not exclude the participant. * Recent intra-articular injection of steroid or other agent (greater than 1 month does not exclude the participant) * Recent knee radiofrequency ablation (greater than 3 months does not exclude the participant) * Recent knee arthroscopic surgery (greater than 3 months does not exclude the participant) * History of knee replacement or open knee surgery on the index knee, defined as the more painful knee on average over the last month. * Inability to walk or climb stairs without significant assistance (e.g. a one-person assist, use a wheel chair; however, the use of a cane does not exclude the participant). * Inability to participate in study procedures (e.g. cognitive impairment limiting ability to understand directions, inability to understand and read English) * Uncontrolled or unstable medical disorder preventing participation in study procedures * History of brain surgery * Tattoos on sensory testing sites * Pregnancy * Breastfeeding * Inability to under knee MRI scan due to incompatible devices or foreign bodies.
Contact & Investigator
Benedict Alter, MD, PhD
PRINCIPAL INVESTIGATOR
University of Pittsburgh
Frequently Asked Questions
Who can join the NCT07308873 clinical trial?
This trial is open to participants of all sexes, aged 45 Years or older, up to 80 Years, studying Knee Osteoarthritis (OA). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07308873 currently recruiting?
Yes, NCT07308873 is actively recruiting participants. Contact the research team at bea51@pitt.edu for enrollment information.
Where is the NCT07308873 trial being conducted?
This trial is being conducted at Pittsburgh, United States.
Who is sponsoring the NCT07308873 clinical trial?
NCT07308873 is sponsored by University of Pittsburgh. The principal investigator is Benedict Alter, MD, PhD at University of Pittsburgh. The trial plans to enroll 300 participants.