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musculoskeletal pain

Total Trials
7
Recruiting Now
7
Trial Phases
Various

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain β€” each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — musculoskeletal pain Clinical Trials

How many clinical trials are currently recruiting for musculoskeletal pain?
ClinicalMetric currently tracks 7 actively recruiting clinical trials for musculoskeletal pain, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 7. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for musculoskeletal pain?
musculoskeletal pain research spans multiple clinical trial phases. Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a musculoskeletal pain clinical trial?
Eligibility criteria for musculoskeletal pain trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Top Sponsors
Ente Ospedaliero Cantonale, Bellinzona 1 trial
University of California, Los Angeles 1 trial
University of Florida 1 trial
The Hong Kong Polytechnic University 1 trial
Defence Medical Rehabilitation Centre, UK 1 trial

Recruiting Clinical Trials

NCT06283199
Recruiting
Comparing Reports Recorded by the Patients at the Time at Which They Feels Pain to What Patients Report at Monthly Visits to Assess Symptoms of Musculoskeletal Diseases.
Enrollment
1,500 pts
Location
Italy, Switzerland
Sponsor
Ente Ospedaliero Cantonale, Be...
View Trial →
NCT07218757
Recruiting
A Pragmatic Trial of EAET for Veterans With Chronic Pain
Enrollment
672 pts
Location
United States
Sponsor
University of California, Los ...
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NCT06512727
Recruiting
The PROACTIVE Study for Black Elders
Enrollment
120 pts
Location
United States
Sponsor
University of Florida
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NCT07826650
Recruiting
The Impact of Acute Pain on Sleep Parameters in the Insomnia Population and Healthy Controls
Enrollment
80 pts
Location
Hong Kong
Sponsor
The Hong Kong Polytechnic Univ...
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NCT06621914
Recruiting
Is Low-load Resistance Training With Blood Flow Restriction Feasible During Rehabilitation of Military Personnel With Lower Limb Injuries? Phase One RCT.
Enrollment
28 pts
Location
United Kingdom
Sponsor
Defence Medical Rehabilitation...
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NCT07827937
Recruiting
Physical Activity in Lawyers: Factors Affecting Musculoskeletal Pain
Enrollment
102 pts
Location
Turkey (Türkiye)
Sponsor
Suleyman Demirel University
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NCT05814497
Recruiting
Supraspinal Processing of Sensory Aspects of Pain
Enrollment
255 pts
Location
United States
Sponsor
Children's Hospital Medical Ce...
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Related Conditions

chronic pain (1) osteoarthritis (1) pain chronic (1) movement evoked pain (1) insomnia (1) healthy adult (1) sleep (1) pain (1) persistent pain (1) physical activity (1) burnout professional (1) migraine in children (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology