NCT07485387 Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort
| NCT ID | NCT07485387 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Korea University |
| Condition | Mild Cognitive Impairment (MCI) |
| Study Type | OBSERVATIONAL |
| Enrollment | 180 participants |
| Start Date | 2025-04-01 |
| Primary Completion | 2027-04-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 180 participants in total. It began in 2025-04-01 with a primary completion date of 2027-04-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this observational study is to learn how daily emotional stress affects cognitive function and inflammation in community-dwelling older adults aged 60 and older in Seoul, Republic of Korea. The main questions it aims to answer are: Does daily psychological stress measured in real-time affect short-term and long-term cognitive function in older adults? Do pro-inflammatory cytokines (such as CRP, IL-6, IL-10, and TNF-α) mediate the relationship between emotional stress and cognitive decline? How do social support and social isolation influence cognitive function and inflammatory biomarkers over time? Participants will: Complete baseline surveys assessing depression, cognitive function, and personal characteristics Use a smartphone app to answer brief surveys about their emotions, cognitive performance, and social interactions 1-6 times daily for two weeks Wear a Galaxy Watch to track sleep quality, heart rate, and physical activity Provide blood samples for inflammatory biomarker analysis Return for follow-up assessments at 6 months and 1 year This study is part of an international collaboration to establish a Korean cohort comparable to the U.S. Einstein Aging Study, with the aim of developing culturally tailored dementia prevention strategies.
Eligibility Criteria
Inclusion Criteria: * Adults aged 60 or older residing in the Republic of Korea * Samsung Galaxy smartphone users capable of using smartphone applications * Sufficient cognitive ability to understand and follow research instructions (MMSE score of 21 or above) * For individuals who do not meet the cognitive criteria, those who understand the study procedures and provide informed consent along with their legal guardian Exclusion Criteria: * Diagnosis of dementia at baseline * Severe visual or hearing impairments that prevent participation in psychological assessments * Illiteracy that prevents participation in cognitive testing * Less than 80% compliance with the 2-day preliminary EMA protocol (one additional attempt allowed after re-training) * Current alcohol or substance abuse * Inability to ambulate or psychiatric conditions that prevent survey participation * Currently undergoing cancer treatment or received chemotherapy within the past 6 months
Contact & Investigator
Sunmi Song
PRINCIPAL INVESTIGATOR
Korea University
Frequently Asked Questions
Who can join the NCT07485387 clinical trial?
This trial is open to participants of all sexes, aged 60 Years or older, studying Mild Cognitive Impairment (MCI). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07485387 currently recruiting?
Yes, NCT07485387 is actively recruiting participants. Contact the research team at sunmi.song0715@gmail.com for enrollment information.
Where is the NCT07485387 trial being conducted?
This trial is being conducted at Seoul, South Korea.
Who is sponsoring the NCT07485387 clinical trial?
NCT07485387 is sponsored by Korea University. The principal investigator is Sunmi Song at Korea University. The trial plans to enroll 180 participants.