NCT07425457 Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)
| NCT ID | NCT07425457 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Attikon Hospital |
| Condition | Arthroplasty |
| Study Type | INTERVENTIONAL |
| Enrollment | 100 participants |
| Start Date | 2026-01-02 |
| Primary Completion | 2027-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 100 participants in total. It began in 2026-01-02 with a primary completion date of 2027-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.
Eligibility Criteria
Inclusion Criteria: * Adults ≥18 years undergoing primary TKA for osteoarthritis. * Cognitively normal and able to self-assess pain and function. * Provide written informed consent. Exclusion Criteria: * Cancer-related knee pain. * Neurological, psychiatric, or medical conditions interfering with assessment. * Chronic opioid users.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07425457 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Arthroplasty. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07425457 currently recruiting?
Yes, NCT07425457 is actively recruiting participants. Contact the research team at dfillipiadis@yahoo.gr for enrollment information.
Where is the NCT07425457 trial being conducted?
This trial is being conducted at Athens, Greece.
Who is sponsoring the NCT07425457 clinical trial?
NCT07425457 is sponsored by Attikon Hospital. The trial plans to enroll 100 participants.