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Recruiting NCT07425457

Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)

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Trial Parameters

Condition Arthroplasty
Sponsor Attikon Hospital
Study Type INTERVENTIONAL
Phase N/A
Enrollment 100
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2026-01-02
Completion 2027-12-31
Interventions
CT-guided Cryoneurolysis of the Genicular Nerves

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Brief Summary

Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.

Eligibility Criteria

Inclusion Criteria: * Adults ≥18 years undergoing primary TKA for osteoarthritis. * Cognitively normal and able to self-assess pain and function. * Provide written informed consent. Exclusion Criteria: * Cancer-related knee pain. * Neurological, psychiatric, or medical conditions interfering with assessment. * Chronic opioid users.

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