Cardiovascular disease trials address coronary artery disease, heart failure, atrial fibrillation, and acute coronary syndromes — collectively the leading cause of mortality globally. After decades of incremental improvement in lipid-lowering and antithrombotic therapy, the field is now exploring RNA-based therapies, gene editing, and cardiac regeneration approaches.
Active research includes PCSK9 inhibitors and inclisiran for LDL reduction, SGLT2 inhibitors in heart failure with preserved ejection fraction (HFpEF), mavacamten for hypertrophic cardiomyopathy, cardiac stem cell therapies, and AI-guided device therapies. Wearables and remote monitoring are also being validated as clinical endpoints.
Enrollment eligibility typically depends on left ventricular ejection fraction (LVEF), NT-proBNP levels, and prior cardiovascular events.
Frequently Asked Questions — heart disease Clinical Trials
How many clinical trials are currently recruiting for heart disease?
ClinicalMetric currently tracks 1 actively recruiting clinical trials for heart disease, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 1. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for heart disease?
heart disease research spans multiple clinical trial phases. Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a heart disease clinical trial?
Eligibility criteria for heart disease trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Top Sponsors
Oregon Health and Science University 1 trial
Recruiting Clinical Trials
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional.
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Last Reviewed: April 2026 ·
Data Methodology