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Medical Condition
multiple sclerosis
Total Trials
9
Recruiting Now
9
Trial Phases
Various
Multiple sclerosis trials now focus beyond relapsing-remitting disease to address the progressive forms (PPMS and SPMS) where anti-inflammatory approaches have shown limited efficacy. Remyelination — regenerating the myelin sheath stripped away by the autoimmune attack — is the most transformative target in current MS research, with several promising candidates entering Phase 2.
Active trials evaluate BTK inhibitors (tolebrutinib, fenebrutinib) for progressive forms, remyelinating agents (PIPE-307, CNM-Au8), high-efficacy induction therapies (cladribine, alemtuzumab) in early aggressive disease, and CAR-T cell approaches for treatment-resistant cases. Optical coherence tomography (OCT) and neurodegeneration biomarkers are advancing as trial endpoints.
Frequently Asked Questions — multiple sclerosis Clinical Trials
How many clinical trials are currently recruiting for multiple sclerosis?
ClinicalMetric currently tracks 9 actively recruiting clinical trials for multiple sclerosis, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 9. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for multiple sclerosis?
multiple sclerosis research spans multiple clinical trial phases. Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a multiple sclerosis clinical trial?
Eligibility criteria for multiple sclerosis trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Top Sponsors
1 trial
1 trial
1 trial
1 trial
1 trial
Recruiting Clinical Trials
NCT04518657
Recruiting
Internet-Delivered Lifestyle Physical Activity Intervention for Cognitive Processing Speed in Multiple Sclerosis
Enrollment
280 pts
Location
United States
Sponsor
University of Illinois at Chic...
NCT06292312
Recruiting
Investigation of the Effectiveness of Craniosacral Therapy in Patients With Multiple Sclerosis.
Enrollment
32 pts
Location
Turkey (Türkiye)
Sponsor
Ankara Yildirim Beyazıt Univer...
NCT01018537
Recruiting
NARCOMS Registry: A Multiple Sclerosis Registry
Enrollment
50,000 pts
Location
United States
Sponsor
University of Texas Southweste...
NCT06546033
Recruiting
Intermittent Fasting and Mediterranean Diet in Patient With Multiple Sclerosis
Enrollment
34 pts
Location
Turkey (Türkiye)
Sponsor
Nigde Omer Halisdemir Universi...
NCT06062693
Recruiting
New Interactive Sensor-home-based Hand Training to Improve Dexterity
Enrollment
160 pts
Location
Switzerland
Sponsor
Luzerner Kantonsspital
NCT06820125
Recruiting
Isolated Versus Combined Cognitive and Motor High-tech Rehabilitation
Enrollment
48 pts
Location
Italy
Sponsor
Universita di Verona
NCT03698149
Recruiting
ECoG BMI for Motor and Speech Control
Enrollment
3 pts
Location
United States
Sponsor
Karunesh Ganguly
NCT07159789
Recruiting
Repetitive Transcranial Magnetic Stimulation (rTMS) in MS Induced Spastic Paraparesis
Enrollment
60 pts
Location
Canada
Sponsor
Clinique Neuro-Outaouais
NCT06788886
Recruiting
Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases
Enrollment
147 pts
Location
United States
Sponsor
Mayo Clinic
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology