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Clinical Trials in Tennessee

Tennessee is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Tennessee and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.

Right now ClinicalMetric tracks 295 actively recruiting studies with Tennessee sites out of 295 registered in total. The busiest research areas in Tennessee are Solid Tumor, Colorectal Cancer, Sickle Cell Disease. Leading sponsors running trials in the state include Vanderbilt University Medical Center, St. Jude Children's Research Hospital, AstraZeneca. By stage, Tennessee trials break down as Phase 1 (71), Phase 2 (91), Phase 3 (65), Phase 4 (12).

All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.

Total Trials
295
Recruiting Now
295
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Top Conditions in Tennessee
Solid Tumor (8)Colorectal Cancer (7)Sickle Cell Disease (6)Prostate Cancer (6)Advanced Solid Tumor (5)Advanced Solid Tumors (5)Cancer (4)Multiple Myeloma (4)Pancreatic Ductal Adenocarcinoma (4)Ovarian Cancer (4)Pancreatic Cancer (4)Head and Neck Squamous Cell Carcinoma (4)

Frequently Asked Questions — Clinical Trials in Tennessee

How many clinical trials are currently recruiting in Tennessee?
ClinicalMetric currently tracks 295 actively recruiting clinical trials with at least one location in Tennessee. The total number of registered studies—including active but not currently enrolling trials—is 295. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Tennessee?
Tennessee hosts clinical trials across a broad range of medical conditions, including Solid Tumor, Colorectal Cancer, Sickle Cell Disease, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Tennessee serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Tennessee?
To join a clinical trial in Tennessee, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Tennessee maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.

Recruiting Trials in Tennessee

NCT07484217 Phase 3
Recruiting
Clinical Assessment of Response in the Treatment of Depression With Daytime Slee...
Condition
Major Depressive Disorder With Excessive Daytime Sleepiness Symptoms
Enrollment
508 pts
Location
United States
Sponsor
Axsome Therapeutics, Inc.
View Trial →
NCT07018323 Phase 2
Recruiting
A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatme...
Condition
Graves' Disease
Enrollment
210 pts
Location
United States, Australia, Brazil
Sponsor
Immunovant Sciences GmbH
View Trial →
NCT05501704 Phase 2
Recruiting
ETHAN - ET for Male BC
Condition
Male Breast Cancer
Enrollment
60 pts
Location
United States
Sponsor
Jose Pablo Leone
View Trial →
NCT06422806 Phase 3
Recruiting
Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone f...
Condition
Metastatic Dedifferentiated Liposarcoma
Enrollment
365 pts
Location
United States, Canada, Puerto Rico
Sponsor
National Cancer Institute (NCI
View Trial →
NCT05848284 N/A
Recruiting
Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacem...
Condition
Tricuspid Regurgitation
Enrollment
30 pts
Location
United States, Canada
Sponsor
VDyne, Inc.
View Trial →
NCT07189936 Phase 2
Recruiting
Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS
Condition
Post-Acute COVID-19 Syndrome
Enrollment
50 pts
Location
United States
Sponsor
Vanderbilt University Medical
View Trial →
NCT05850234 Phase 1, Phase 2
Recruiting
AZD0120 in Relapsed/Refractory Multiple Myeloma (DURGA-1)
Condition
Relapsed/Refractory Multiple Myeloma
Enrollment
232 pts
Location
United States
Sponsor
AstraZeneca
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NCT06456593 Phase 2
Recruiting
Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active...
Condition
Moderately to Severely Active Crohn Disease
Enrollment
212 pts
Location
United States, Belgium, Czechia
Sponsor
Abivax S.A.
View Trial →
NCT06401421 N/A
Recruiting
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Brea...
Condition
Breast Cancer
Enrollment
1,800 pts
Location
United States, Canada
Sponsor
Exact Sciences Corporation
View Trial →
NCT05919511 N/A
Recruiting
Observational Study for Patients at Risk for Chronic Graft-Versus-Host Disease
Condition
cGVHD
Enrollment
1,500 pts
Location
United States
Sponsor
Incyte Corporation
View Trial →
NCT07440225 Phase 2, Phase 3
Recruiting
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-...
Condition
Macular Degeneration
Enrollment
960 pts
Location
United States, Argentina, Australia
Sponsor
EyeBiotech Ltd.
View Trial →
NCT06930976 N/A
Recruiting
Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells
Condition
Glucose
Enrollment
12 pts
Location
United States
Sponsor
Vanderbilt University Medical
View Trial →
NCT05653388 N/A
Recruiting
Metastatic Leiomyosarcoma Biomarker Protocol
Condition
Leiomyosarcoma
Enrollment
200 pts
Location
United States, Australia
Sponsor
University of Michigan Rogel C
View Trial →
NCT06424288 Phase 3
Recruiting
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps Peop...
Condition
Heart Failure
Enrollment
6,712 pts
Location
United States, Argentina, Australia
Sponsor
Boehringer Ingelheim
View Trial →
NCT06256588 Phase 3
Recruiting
A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants Wit...
Condition
Neoplasms, Head and Neck
Enrollment
864 pts
Location
United States, Argentina, Australia
Sponsor
GlaxoSmithKline
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NCT07753850 Phase 2
Recruiting
A Study of SL-325 in Crohn's Disease Patients
Condition
Crohn's Disease
Enrollment
232 pts
Location
United States
Sponsor
Shattuck Labs, Inc.
View Trial →
NCT07355296 Phase 2
Recruiting
PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents...
Condition
Proteinuric Kidney Diseases
Enrollment
132 pts
Location
United States, Argentina, Australia
Sponsor
Boehringer Ingelheim
View Trial →
NCT07181473 Phase 1
Recruiting
A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TJ101 in Patien...
Condition
Lung Cancer (NSCLC)
Enrollment
200 pts
Location
United States, China
Sponsor
Phrontline Biopharma
View Trial →
NCT06465069 Phase 1
Recruiting
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Canc...
Condition
Metastatic Solid Tumor
Enrollment
460 pts
Location
United States, Australia, China
Sponsor
Eli Lilly and Company
View Trial →
NCT07383441 Phase 3
Recruiting
Adding Biotherapy or Placebo to Standard Treatment for Advanced Kidney Cancer
Condition
Advanced Clear Cell Renal Cell Carcinoma
Enrollment
718 pts
Location
United States
Sponsor
SWOG Cancer Research Network
View Trial →
NCT05061550 Phase 2
Recruiting
Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer
Condition
Non-small Cell Lung Cancer
Enrollment
630 pts
Location
United States, Belgium, Canada
Sponsor
AstraZeneca
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NCT07559903 N/A
Recruiting
ANDREAS Registry (Assessment of Novel Drug-coated Balloon Revascularization: Eff...
Condition
Coronary Artery Disease
Enrollment
5,000 pts
Location
United States, Germany, Serbia
Sponsor
Emory University
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NCT07549503 Phase 2
Recruiting
Early Signals of the Transition From Immune Quiescence to Activation in the Live...
Condition
Liver Transplant
Enrollment
100 pts
Location
United States
Sponsor
National Institute of Allergy
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NCT07629960 Phase 1, Phase 2
Recruiting
A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring...
Condition
Advanced Solid Tumor
Enrollment
265 pts
Location
United States, Spain
Sponsor
Blueprint Medicines Corporatio
View Trial →
NCT06399692 Phase 3
Recruiting
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARG...
Condition
Coronary Artery Disease
Enrollment
600 pts
Location
United States
Sponsor
Weill Medical College of Corne
View Trial →
Page 9 of 12 — 295 trials total
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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology