State TN
Clinical Trials in Tennessee
Tennessee is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Tennessee and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 296 actively recruiting studies with Tennessee sites out of 296 registered in total. The busiest research areas in Tennessee are Breast Cancer, Heart Failure, Colorectal Cancer. Leading sponsors running trials in the state include Vanderbilt University Medical Center, St. Jude Children's Research Hospital, Merck Sharp & Dohme LLC. By stage, Tennessee trials break down as Phase 1 (74), Phase 2 (76), Phase 3 (70), Phase 4 (6).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Tennessee
Frequently Asked Questions — Clinical Trials in Tennessee
How many clinical trials are currently recruiting in Tennessee?
ClinicalMetric currently tracks 296 actively recruiting clinical trials with at least one location in Tennessee. The total number of registered studies—including active but not currently enrolling trials—is 296. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Tennessee?
Tennessee hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Heart Failure, Colorectal Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Tennessee serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Tennessee?
To join a clinical trial in Tennessee, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Tennessee maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Tennessee
NCT06445608 N/A
Recruiting
PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm
Condition
Coronary Artery Disease
Enrollment
310 pts
Location
United States
Sponsor
Kardion Inc
NCT07054190 Phase 2
Recruiting
A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-M...
Condition
Breast Cancer
Enrollment
120 pts
Location
United States, Argentina, Brazil
Sponsor
Hoffmann-La Roche
NCT04905017 N/A
Recruiting
Trisol System EFS Study
Condition
Tricuspid Regurgitation
Enrollment
30 pts
Location
United States
Sponsor
Trisol Medical
NCT05375968 Phase 2
Recruiting
Splanchnic Venous Capacitance in Postural Tachycardia Syndrome
Condition
Postural Tachycardia Syndrome (POTS)
Enrollment
50 pts
Location
United States
Sponsor
Vanderbilt University Medical
NCT06029491 N/A
Recruiting
The Pivotal Study of RapidPulseTM Aspiration System
Condition
Acute Ischemic Stroke
Enrollment
170 pts
Location
United States, France, Spain
Sponsor
RapidPulse, Inc
NCT05664113 Phase 1
Recruiting
Feasibility, Safety, and Potential Efficacy of Fecal Microbiota Transplantation ...
Condition
Gastro-Intestinal Disorder
Enrollment
10 pts
Location
United States
Sponsor
St. Jude Children's Research H
NCT04573660 N/A
Recruiting
Abbott Vascular Medical Device Registry
Condition
Acute Myocardial Infarction
Enrollment
3,784 pts
Location
United States, Australia, Austria
Sponsor
Abbott Medical Devices
NCT07225543 Phase 2
Recruiting
2-HOBA in Systemic Lupus Erythematosus
Condition
Systemic Lupus Erthematosus (SLE)
Enrollment
42 pts
Location
United States
Sponsor
Vanderbilt University Medical
NCT07198074 Phase 3
Recruiting
Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Ca...
Condition
Advanced Endometrial Carcinoma
Enrollment
255 pts
Location
United States
Sponsor
National Cancer Institute (NCI
NCT07113210 Phase 4
Recruiting
Quality of Life in Presbyopic Patients Who Are Treated With Qlosi
Condition
Presbyopia
Enrollment
36 pts
Location
United States
Sponsor
Southern College of Optometry
NCT06317662 Phase 2
Recruiting
Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer I...
Condition
Acute Leukemia of Ambiguous Lineage
Enrollment
153 pts
Location
United States, Puerto Rico
Sponsor
National Cancer Institute (NCI
NCT06112418 N/A
Recruiting
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Pr...
Condition
Diabetes Mellitus, Type 2
Enrollment
7,500 pts
Location
United States
Sponsor
Cleerly, Inc.
NCT06524882 Phase 3
Recruiting
Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age
Condition
Amblyopia
Enrollment
252 pts
Location
United States
Sponsor
Jaeb Center for Health Researc
NCT00950118 N/A
Recruiting
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science
Condition
Congenital Diaphragmatic Hernia
Enrollment
3,000 pts
Location
United States, Egypt
Sponsor
Columbia University
NCT07529691 N/A
Recruiting
Survey on Physical Activity and Qualify of Life in Fibromuscular Dysplasia
Condition
Fibromuscular Dysplasia of Arteries
Enrollment
2,000 pts
Location
United States
Sponsor
Vanderbilt University Medical
NCT06714591 Phase 1
Recruiting
Evaluate the Safety, Tolerability, Pharmacokinetic Profile, Efficacy of Bl-M11D1
Condition
Relapsed/Refractory Acute Myeloid Leukemia
Enrollment
120 pts
Location
United States
Sponsor
SystImmune Inc.
NCT06725277 N/A
Recruiting
The OBSERVE Protocol
Condition
Major Depression Disorder
Enrollment
450 pts
Location
United States
Sponsor
Yale University
NCT07113522 Phase 2
Recruiting
A Phase 2 Study to Evaluate Therapies for Inflammatory Bowel Disease
Condition
Inflammatory Bowel Disease (IBD)
Enrollment
140 pts
Location
United States, Canada, Georgia
Sponsor
Mirador Therapeutics, Inc.
NCT05705531 N/A
Recruiting
A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatm...
Condition
Cardiovascular Disorder
Enrollment
190 pts
Location
United States, Canada
Sponsor
Children's Oncology Group
NCT05410145 Phase 1, Phase 2
Recruiting
A Study of D3S-001 Monotherapy or Combination Therapy in Subjects With Advanced ...
Condition
KRAS P.G12C
Enrollment
442 pts
Location
United States, Australia, China
Sponsor
D3 Bio (Wuxi) Co., Ltd
NCT07144345 Phase 3
Recruiting
Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Face a...
Condition
Actinic Keratosis
Enrollment
160 pts
Location
United States
Sponsor
Sun Pharmaceutical Industries,
NCT03683251 Phase 3
Recruiting
Extension Study for the Port Delivery System With Ranibizumab (Portal)
Condition
Neovascular Age-Related Macular Degeneration
Enrollment
1,000 pts
Location
United States, Argentina, Australia
Sponsor
Hoffmann-La Roche
NCT07191119 N/A
Recruiting
Transcutaneous Auricular Vagus Nerve Stimulation for Insomnia in Survivors of Ch...
Condition
Survivor of Childhood Cancer
Enrollment
40 pts
Location
United States
Sponsor
St. Jude Children's Research H
NCT07614776 Phase 3
Recruiting
A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versu...
Condition
Neovascular Age-related Macular Degeneration
Enrollment
304 pts
Location
United States, Latvia, Poland
Sponsor
Amgen
NCT06747910 N/A
Recruiting
Assessment of Remote Approaches for Identification of Autonomic Dysfunction Amon...
Condition
Childhood Cancer
Enrollment
188 pts
Location
United States
Sponsor
St. Jude Children's Research H
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology