State PA
Clinical Trials in Pennsylvania
Pennsylvania is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Pennsylvania and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 484 actively recruiting studies with Pennsylvania sites out of 484 registered in total. The busiest research areas in Pennsylvania are Breast Cancer, Ovarian Cancer, Colorectal Cancer. Leading sponsors running trials in the state include University of Pennsylvania, University of Pittsburgh, National Cancer Institute (NCI). By stage, Pennsylvania trials break down as Phase 1 (77), Phase 2 (124), Phase 3 (101), Phase 4 (18).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Pennsylvania
Frequently Asked Questions — Clinical Trials in Pennsylvania
How many clinical trials are currently recruiting in Pennsylvania?
ClinicalMetric currently tracks 484 actively recruiting clinical trials with at least one location in Pennsylvania. The total number of registered studies—including active but not currently enrolling trials—is 484. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Pennsylvania?
Pennsylvania hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Ovarian Cancer, Colorectal Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Pennsylvania serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Pennsylvania?
To join a clinical trial in Pennsylvania, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Pennsylvania maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Pennsylvania
NCT06282406 N/A
Recruiting
Pupil-Indexed Noninvasive Neuromodulation
Condition
Paresis
Enrollment
110 pts
Location
United States
Sponsor
VA Office of Research and Deve
NCT06551116 N/A
Recruiting
QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 i...
Condition
HER2-positive Metastatic Breast Cancer
Enrollment
200 pts
Location
United States
Sponsor
Abramson Cancer Center at Penn
NCT06630806 Phase 1
Recruiting
A Study to Investigate the Safety and Efficacy of SAR446523 Injected Subcutaneou...
Condition
Plasma Cell Myeloma Refractory
Enrollment
87 pts
Location
United States, Australia, Canada
Sponsor
Sanofi
NCT07027306 N/A
Recruiting
The Osteoporotic Fracture Classification-based Scoring System for Treatment Deci...
Condition
Osteoporotic Fractures
Enrollment
648 pts
Location
United States, Argentina, Brazil
Sponsor
AO Foundation, AO Spine
NCT06626516 Phase 1, Phase 2
Recruiting
Tebentafusp-tebn With LDT in Metastatic UM
Condition
Metastatic Uveal Melanoma
Enrollment
109 pts
Location
United States
Sponsor
Thomas Jefferson University
NCT07100379 N/A
Recruiting
Balloon Inflation Time for Esophageal Strictures (BITES): A Randomized Multi-Cen...
Condition
Esophageal Atresia With Tracheo-esophageal Fistula
Enrollment
128 pts
Location
United States
Sponsor
Boston Children's Hospital
NCT06043362 N/A
Recruiting
Use of Nicotine Pouches Among Daily Smokers
Condition
Tobacco Dependence
Enrollment
375 pts
Location
United States
Sponsor
Milton S. Hershey Medical Cent
NCT03490929 Phase 4
Recruiting
CEUS for Blunt Abdominal Trauma in Children
Condition
Trauma Abdomen
Enrollment
146 pts
Location
United States
Sponsor
Children's Hospital of Philade
NCT07503210 Phase 3
Recruiting
AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Help...
Condition
Obesity
Enrollment
600 pts
Location
United States, Argentina, Australia
Sponsor
Novo Nordisk A/S
NCT04853251 Phase 4
Recruiting
A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age...
Condition
Neovascular Age-related Macular Degeneration
Enrollment
188 pts
Location
United States
Sponsor
Genentech, Inc.
NCT06773026 Phase 2
Recruiting
Study of Sodium Phenylbutyrate (ACER-001) for the Treatment of Pediatric and Adu...
Condition
Medium-chain Acyl-CoA Dehydrogenase Deficiency
Enrollment
24 pts
Location
United States
Sponsor
Jerry Vockley, MD, PhD
NCT06838676 Phase 2
Recruiting
ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered ...
Condition
Diffuse Intrinsic Pontine Gliomas (DIPG)
Enrollment
60 pts
Location
United States, Australia, Canada
Sponsor
Nationwide Children's Hospital
NCT02323581 N/A
Recruiting
Endovascular Treatment of TAAA and Aortic Arch Aneurysms Using Fenestrated and B...
Condition
Aortic Aneurysm, Thoracoabdominal
Enrollment
520 pts
Location
United States
Sponsor
Darren Schneider, M.D.
NCT05783765 N/A
Recruiting
Food Genetics Behavior Study
Condition
Obesity, Childhood
Enrollment
242 pts
Location
United States
Sponsor
University of Pennsylvania
NCT04263792 Phase 1
Recruiting
[18F]Fluoropropyl-Trimethoprim ([18F]F-TMP) PET/CT Imaging to Evaluate Biodistri...
Condition
Bacterial Infections
Enrollment
20 pts
Location
United States
Sponsor
University of Pennsylvania
NCT06843512 N/A
Recruiting
Identifying Changes in Food Behaviors Associated With Beginning GLP-1 Medication
Condition
Weight Loss
Enrollment
25 pts
Location
United States
Sponsor
Penn State University
NCT07029581 Phase 2
Recruiting
Phase 2, Efficacy and Safety Study of ACP-204 in Lewy Body Dementia Psychosis
Condition
Lewy Body Dementia Psychosis
Enrollment
180 pts
Location
United States, Bulgaria, Czechia
Sponsor
ACADIA Pharmaceuticals Inc.
NCT05561738 N/A
Recruiting
Nicotinamide Riboside in Ulcerative Colitis
Condition
Ulcerative Colitis
Enrollment
40 pts
Location
United States
Sponsor
University of Pittsburgh
NCT07038343 Phase 1, Phase 2
Recruiting
AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in P...
Condition
Solid Tumor Cancer
Enrollment
480 pts
Location
United States
Sponsor
Avenzo Therapeutics, Inc.
NCT04875429 N/A
Recruiting
Zenith® Fenestrated+ Clinical Study
Condition
Aortic Aneurysm, Abdominal
Enrollment
105 pts
Location
United States, United Kingdom
Sponsor
Cook Research Incorporated
NCT07006675 Phase 3
Recruiting
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Frac...
Condition
Tibial Fractures
Enrollment
1,000 pts
Location
United States, Canada
Sponsor
Major Extremity Trauma Researc
NCT06174272 N/A
Recruiting
Transitional Care Program for Fluid Overload in Cirrhosis
Condition
Cirrhosis, Liver
Enrollment
20 pts
Location
United States
Sponsor
Milton S. Hershey Medical Cent
NCT07089875 Phase 3
Recruiting
A Study of Dotinurad Versus Allopurinol in Participants With Gout
Condition
Gout
Enrollment
500 pts
Location
United States, Poland, Spain
Sponsor
Crystalys Therapeutics
NCT05092022 N/A
Recruiting
St. Joseph's HPV Self-sampling: Offering a Self-sampling Option in Clinic
Condition
Cervical Cancer Screening
Enrollment
50 pts
Location
United States
Sponsor
Milton S. Hershey Medical Cent
NCT06779773 N/A
Recruiting
A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice ...
Condition
Geographic Atrophy
Enrollment
500 pts
Location
United States
Sponsor
Astellas Pharma Global Develop
Page 1 of 20 — 484 trials total
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: July 2026 · Data Methodology