State IL
Clinical Trials in Illinois
Illinois is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Illinois and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 417 actively recruiting studies with Illinois sites out of 417 registered in total. The busiest research areas in Illinois are Breast Cancer, Endometrial Cancer, Hypertension. Leading sponsors running trials in the state include University of Chicago, Northwestern University, University of Illinois at Chicago. By stage, Illinois trials break down as Phase 1 (66), Phase 2 (118), Phase 3 (105), Phase 4 (13).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Illinois
Frequently Asked Questions — Clinical Trials in Illinois
How many clinical trials are currently recruiting in Illinois?
ClinicalMetric currently tracks 417 actively recruiting clinical trials with at least one location in Illinois. The total number of registered studies—including active but not currently enrolling trials—is 417. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Illinois?
Illinois hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Endometrial Cancer, Hypertension, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Illinois serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Illinois?
To join a clinical trial in Illinois, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Illinois maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Illinois
NCT07218926 Phase 3
Recruiting
A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastr...
Condition
Gastrointestinal Neoplasms
Enrollment
450 pts
Location
United States, Australia, Belgium
Sponsor
GlaxoSmithKline
NCT07507643 Phase 3
Recruiting
A Study of Methylprednisolone in People Having Liver Surgery
Condition
Hepatectomy
Enrollment
750 pts
Location
United States
Sponsor
Memorial Sloan Kettering Cance
NCT06996379 N/A
Recruiting
J-Tip Use for Paracentesis in Adults With Ascites
Condition
Evaluate Patient Comfort Level During Paracentesis by Numbing Skin With a Needle-less Device, Instead of Using a Needle to Numb the Skin
Enrollment
110 pts
Location
United States
Sponsor
Northwestern University
NCT06619561 Phase 2
Recruiting
A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host ...
Condition
Chronic Graft-Versus-Host Disease (cGVHD)
Enrollment
48 pts
Location
United States
Sponsor
Deciphera Pharmaceuticals, LLC
NCT05920356 Phase 3
Recruiting
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab P...
Condition
Non-Small Cell Lung Cancer (NSCLC)
Enrollment
750 pts
Location
United States, Argentina, Australia
Sponsor
Amgen
NCT07489066 Phase 2
Recruiting
Symbiotic-Lung-10: A Study to Learn About PF-08634404 Alone or in Combination in...
Condition
Carcinoma
Enrollment
120 pts
Location
United States, China, Israel
Sponsor
Pfizer
NCT05369429 N/A
Recruiting
My Wellbeing Guide: A Novel Tool for Managing Stress and Improving Quality of Li...
Condition
Cancer
Enrollment
6,516 pts
Location
United States
Sponsor
Northwestern University
NCT06152575 Phase 3
Recruiting
MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in P...
Condition
Multiple Myeloma
Enrollment
492 pts
Location
United States, Argentina, Australia
Sponsor
Pfizer
NCT06477172 N/A
Recruiting
Autologous Hair Follicle Derived Secretome as Adjunct to Aesthetic Procedures
Condition
Post Procedural Erythema
Enrollment
500 pts
Location
United States, Canada
Sponsor
Acorn Biolabs Inc.
NCT06624670 Phase 3
Recruiting
A Study to Test Whether Spesolimab Helps People With a Skin Condition Called Pyo...
Condition
Pyoderma Gangrenosum
Enrollment
90 pts
Location
United States, Argentina, Australia
Sponsor
LEO Pharma
NCT07603856 Phase 2
Recruiting
A Study Evaluating The Combination of Immunotherapy With Radiotherapy in Non-Sma...
Condition
Non-Small Cell Lung Cancer
Enrollment
39 pts
Location
United States
Sponsor
University of Chicago
NCT06324357 Phase 1, Phase 2
Recruiting
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in...
Condition
Metastatic Breast Cancer
Enrollment
768 pts
Location
United States, Belgium, China
Sponsor
Boehringer Ingelheim
NCT06554275 N/A
Recruiting
CCHS Secure Health-hub Advancing Research Efforts (CCHS SHARE)
Condition
Congenital Central Hypoventilation Syndrome
Enrollment
125 pts
Location
United States
Sponsor
Ann & Robert H Lurie Children'
NCT05076175 Phase 2, Phase 3
Recruiting
A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Mod...
Condition
Colitis, Ulcerative
Enrollment
120 pts
Location
United States, Australia, Belgium
Sponsor
Bristol-Myers Squibb
NCT06526819 Phase 1, Phase 2
Recruiting
SMP-3124LP in Adults With Advanced Solid Tumors
Condition
Solid Tumor
Enrollment
120 pts
Location
United States, Japan
Sponsor
Sumitomo Pharma America, Inc.
NCT07623902 N/A
Recruiting
Evaluation of Gixam's Efficacy Predicting the Presence of Advanced and Non-advan...
Condition
CRC Screening
Enrollment
1,436 pts
Location
United States
Sponsor
Jubaan Ltd.
NCT06095128 Phase 4
Recruiting
A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)
Condition
Ulcerative Colitis
Enrollment
65 pts
Location
United States, Canada
Sponsor
Takeda
NCT05313165 N/A
Recruiting
PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-St...
Condition
Critical Limb Ischemia
Enrollment
100 pts
Location
United States
Sponsor
LimFlow, Inc.
NCT06134167 N/A
Recruiting
Transdermal Compress IDE Study
Condition
Prosthesis and Implants
Enrollment
100 pts
Location
United States
Sponsor
Balmoral Medical company
NCT06272045 N/A
Recruiting
Early Intervention to Promote Cardiovascular Health of Mothers and Children
Condition
Cardiovascular Health
Enrollment
6,618 pts
Location
United States
Sponsor
JHSPH Center for Clinical Tria
NCT06898034 N/A
Recruiting
Postpartum Ultrasound Evaluation to Assess Risk of Hemorrhage
Condition
Pregnancy Related
Enrollment
1,725 pts
Location
United States
Sponsor
Endeavor Health
NCT06708299 Phase 3
Recruiting
CardiolRx in Recurrent Pericarditis (MAVERIC Phase-3)
Condition
Recurrent Pericarditis
Enrollment
110 pts
Location
United States, Canada, Greece
Sponsor
Cardiol Therapeutics Inc.
NCT05504837 Phase 1
Recruiting
A Study Assessing KB407 for the Treatment of Cystic Fibrosis
Condition
Cystic Fibrosis
Enrollment
20 pts
Location
United States
Sponsor
Krystal Biotech, Inc.
NCT07545772 Phase 2
Recruiting
A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome...
Condition
Irritable Bowel Syndrome
Enrollment
342 pts
Location
United States, Belgium, Canada
Sponsor
Eli Lilly and Company
NCT06551077 N/A
Recruiting
Posterior Rectus Sheath Hiatal Augmentation in Paraesophageal Hernia Repair
Condition
Paraesophageal Hernia
Enrollment
100 pts
Location
United States
Sponsor
University of Chicago
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology