State IL
Clinical Trials in Illinois
Illinois is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Illinois and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 398 actively recruiting studies with Illinois sites out of 398 registered in total. The busiest research areas in Illinois are Schizophrenia, Obesity, Breast Cancer. Leading sponsors running trials in the state include University of Chicago, Northwestern University, University of Illinois Chicago. By stage, Illinois trials break down as Phase 1 (55), Phase 2 (104), Phase 3 (106), Phase 4 (15).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Illinois
Frequently Asked Questions — Clinical Trials in Illinois
How many clinical trials are currently recruiting in Illinois?
ClinicalMetric currently tracks 398 actively recruiting clinical trials with at least one location in Illinois. The total number of registered studies—including active but not currently enrolling trials—is 398. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Illinois?
Illinois hosts clinical trials across a broad range of medical conditions, including Schizophrenia, Obesity, Breast Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Illinois serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Illinois?
To join a clinical trial in Illinois, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Illinois maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Illinois
NCT06742996 Phase 3
Recruiting
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib ...
Condition
Mantle Cell Lymphoma
Enrollment
300 pts
Location
United States, Argentina, Australia
Sponsor
BeOne Medicines
NCT06224218 N/A
Recruiting
Prostate Single Port & Laser Enucleation Comparison Trial
Condition
Prostate Hyperplasia
Enrollment
116 pts
Location
United States
Sponsor
University of Illinois Chicago
NCT07361562 Phase 1
Recruiting
A Study of a Selective ERBB2 Inhibitor (CGT4255), in Patients With Advanced Soli...
Condition
Advanced Solid Tumor, Adult
Enrollment
100 pts
Location
United States
Sponsor
Cogent Biosciences, Inc.
NCT06698146 N/A
Recruiting
Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed ...
Condition
Liver Transplant Surgery
Enrollment
80 pts
Location
United States
Sponsor
Northwestern University
NCT03945162 Phase 2
Recruiting
Intravesical Photodynamic Therapy ("PDT") in BCG-Unresponsive/Intolerant Non-Mus...
Condition
Non-Muscle Invasive Bladder Cancer ("NMIBC") Unresponsive/Intolerant to BCG
Enrollment
90 pts
Location
United States, Canada
Sponsor
Theralase® Technologies Inc.
NCT05893888 Phase 2, Phase 3
Recruiting
A Study Evaluating the Safety and Efficacy of PRV111, PRV211, and PRV131 in Subj...
Condition
Oral Squamous Cell Carcinoma
Enrollment
40 pts
Location
United States
Sponsor
Privo Technologies
NCT04398628 N/A
Recruiting
ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
Condition
Hematologic Disorder
Enrollment
3,000 pts
Location
United States
Sponsor
American Thrombosis and Hemost
NCT07186101 Phase 2
Recruiting
LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately ...
Condition
Ulcerative Colitis
Enrollment
252 pts
Location
United States, Austria, Brazil
Sponsor
Eli Lilly and Company
NCT07204275 Phase 2, Phase 3
Recruiting
Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants...
Condition
Primary Membranous Nephropathy
Enrollment
176 pts
Location
United States, Australia, Brazil
Sponsor
Vertex Pharmaceuticals Incorpo
NCT06317701 N/A
Recruiting
Metabolic Endpoints for Obstructive Sleep Apnea Following Twelfth Cranial Nerve ...
Condition
Obstructive Sleep Apnea
Enrollment
30 pts
Location
United States
Sponsor
University of Chicago
NCT07007312 Phase 3
Recruiting
Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With...
Condition
Acute Myeloid Leukemia (AML)
Enrollment
1,300 pts
Location
United States, Australia, Belgium
Sponsor
Kura Oncology, Inc.
NCT07085767 Phase 3
Recruiting
Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/...
Condition
Breast Cancer
Enrollment
1,000 pts
Location
United States, Australia, Austria
Sponsor
Olema Pharmaceuticals, Inc.
NCT06983041 N/A
Recruiting
Clinical Study of a Vaginal Cooling Device for the Treatment of Vulvovaginal Can...
Condition
Vulvovaginal Candidiasis (VVC)
Enrollment
55 pts
Location
United States
Sponsor
Coologics, Inc
NCT07232602 Phase 1, Phase 2
Recruiting
KEYMAKER-U04 Substudy 04D: A Clinical Study of New Treatments Given With Enfortu...
Condition
Bladder Cancer
Enrollment
55 pts
Location
United States, Chile, France
Sponsor
Merck Sharp & Dohme LLC
NCT07789041 N/A
Recruiting
Use of PuraStat Following Aquablation to Determine if There is Change in Hematur...
Condition
BPH (Benign Prostatic Hyperplasia)
Enrollment
50 pts
Location
United States
Sponsor
Endeavor Health
NCT05421741 Phase 4
Recruiting
Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial
Condition
Osteomyelitis Tibia
Enrollment
242 pts
Location
United States
Sponsor
Wake Forest University Health
NCT05488457 Phase 2
Recruiting
Oxytocin Pharmacokinetics and Pharmacodynamics
Condition
Post Partum Hemorrhage
Enrollment
100 pts
Location
United States
Sponsor
Stanford University
NCT07652970 N/A
Recruiting
Tele-CE in Severe Stroke
Condition
Stroke
Enrollment
40 pts
Location
United States
Sponsor
University of Illinois Chicago
NCT04638647 Phase 4
Recruiting
Secukinumab Open Label Roll-over Extension Protocol
Condition
Autoimmunity, Inflammation
Enrollment
1,000 pts
Location
United States, Belgium, Brazil
Sponsor
Novartis Pharmaceuticals
NCT06438315 N/A
Recruiting
SuperSaturated Oxygen Comprehensive Observational Registry
Condition
STEMI - ST Elevation Myocardial Infarction
Enrollment
1,000 pts
Location
United States
Sponsor
TherOx
NCT06282510 Phase 4
Recruiting
Nasal Antisepsis for C. Auris Prevention
Condition
Candida Auris Infection
Enrollment
120 pts
Location
United States
Sponsor
Mary K Hayden
NCT05700617 EARLY_Phase 1
Recruiting
Cardiac Power Output in Cardiogenic Shock Patients
Condition
Heart Failure
Enrollment
5 pts
Location
United States
Sponsor
University of Chicago
NCT04434040 Phase 2
Recruiting
Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)
Condition
Breast Cancer
Enrollment
40 pts
Location
United States
Sponsor
Dana-Farber Cancer Institute
NCT07573176 Phase 3
Recruiting
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Ma...
Condition
Depressive Disorder, Major
Enrollment
600 pts
Location
United States, Argentina, Brazil
Sponsor
Janssen Research & Development
NCT07498140 N/A
Recruiting
Procedural Framing and Epidural Steroid Injection Outcomes
Condition
Lumbosacral Radiculopathy
Enrollment
210 pts
Location
United States, Thailand, Ukraine
Sponsor
Northwestern University
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology