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Medical Condition
atrial fibrillation
Total Trials
36
Recruiting Now
36
Trial Phases
Phase 3, Phase 4, EARLY_Phase 1
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, affecting over 33 million people worldwide and conferring a fivefold increased risk of stroke. Clinical trials in AF address three core problems: rhythm control (restoring and maintaining sinus rhythm), rate control (controlling heart rate in persistent AF), and stroke prevention (anticoagulation). The EAST-AFNET 4 trial established early rhythm control as superior to a rate-control strategy in reducing cardiovascular events, reshaping international guidelines.
Current trials evaluate non-vitamin K oral anticoagulants (NOACs) in underserved populations, pulse field ablation versus radiofrequency ablation (ADVENT trial showed non-inferiority), left atrial appendage occlusion devices (WATCHMAN FLX) versus NOAC therapy in patients with bleeding risk, and novel antiarrhythmic drugs with improved safety profiles. Digital health trials using smartwatch-detected AF episodes are emerging as enrollment and monitoring tools.
CHA₂DS₂-VASc score determines anticoagulation eligibility; prior ablation history and type of AF (paroxysmal, persistent, long-standing persistent) determine eligibility for rhythm control trials.
Frequently Asked Questions — atrial fibrillation Clinical Trials
How many clinical trials are currently recruiting for atrial fibrillation?
ClinicalMetric currently tracks 36 actively recruiting clinical trials for atrial fibrillation, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 36. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for atrial fibrillation?
atrial fibrillation research spans Phase 1 (1 trial), Phase 3 (4 trials), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a atrial fibrillation clinical trial?
Eligibility criteria for atrial fibrillation trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1 1
Phase 3 4
Phase 4 1
Top Sponsors
2 trials
2 trials
2 trials
2 trials
1 trial
Recruiting Clinical Trials
NCT02219984
Recruiting
START-Register: Survey on Anticoagulated Patients Register
Enrollment
15,410 pts
Location
Italy
Sponsor
GUALTIERO PALARETI
NCT05009797
Recruiting
PROSPective Evaluation of Outcome After CatheTer Ablation in Atrial Fibrillation
Enrollment
750 pts
Location
France
Sponsor
University Hospital, Lille
NCT06075628
Recruiting
Long-Term Outcomes of LAA Contrast Flow in CT Scans After Endocardial LAA Closure: The CF-CT Registry
Enrollment
100 pts
Location
United States
Sponsor
Kansas City Heart Rhythm Resea...
NCT05928728 Phase 3
Recruiting
The COLchicine and Atrial FIBrillation Trial
Enrollment
500 pts
Location
Denmark
Sponsor
Herlev and Gentofte Hospital
NCT06431828
Recruiting
Remote Symptom Review in Patients With Implantable Diagnostic Holter
Enrollment
60 pts
Location
Spain
Sponsor
Andres Iñiguez Romo
NCT05960721
Recruiting
Low-dose NOAC Versus GDMT After LAAO
Enrollment
4,220 pts
Location
China
Sponsor
Xijing Hospital
NCT03357926
Recruiting
Prospective Database for Prediction of Atrial Fibrillation in Pacemaker and ICD Patients
Enrollment
250 pts
Location
Austria
Sponsor
Medical University of Graz
NCT03243175 Phase 3
Recruiting
Avoiding Anticoagulation After IntraCerebral Haemorrhage
Enrollment
300 pts
Location
France
Sponsor
University Hospital, Lille
NCT04642430 Phase 4
Recruiting
COmparison of Bleeding Risk Between Rivaroxaban and Apixaban in Patients With Atrial Fibrillation
Enrollment
3,018 pts
Location
Canada
Sponsor
Ottawa Hospital Research Insti...
NCT04800913
Recruiting
The Role of Multimodality Imaging in Left Atrial Appendage Closure
Enrollment
44 pts
Location
Hungary
Sponsor
Hungarian Institute of Cardiol...
NCT07428967
Recruiting
AV Node Ablation and CONDUCTion System Pacing for Atrial Fibrillation With Preserved Left Ventricular Function
Enrollment
86 pts
Location
Germany
Sponsor
St. Josefs-Hospital Wiesbaden ...
NCT05532878
Recruiting
Pharmacokinetics of Apixaban in Peritoneal Dialysis
Enrollment
50 pts
Location
Hong Kong
Sponsor
Chinese University of Hong Kon...
NCT04976348
Recruiting
The Multicenter Cardiology Monitoring Platform Registry
Enrollment
40,000 pts
Location
Netherlands
Sponsor
Maastricht University Medical ...
NCT04628078
Recruiting
LAAC-registry: Clinical Outcome After Echocardiography-guided LAA-closure
Enrollment
1,000 pts
Location
Switzerland
Sponsor
Insel Gruppe AG, University Ho...
NCT04997824
Recruiting
Artificial Intelligence Guided Patient Selection for Atrial Fibrillation Catheter Ablation: Randomized Clinical Trial (AI-PAFA Trial)
Enrollment
1,000 pts
Location
South Korea
Sponsor
Yonsei University
NCT02997254
Recruiting
COMparison of Physiological Algorithms for Real-time Evaluation of Atrial Fibrillation
Enrollment
1,000 pts
Location
United States
Sponsor
Stanford University
NCT05353140
Recruiting
LAAO Versus NOAC in Patients with AF and PCI
Enrollment
1,386 pts
Location
China
Sponsor
Xijing Hospital
NCT03611816
Recruiting
Biological Bank for Atrial Fibrillation and Stroke
Enrollment
1,000 pts
Location
France
Sponsor
Hospices Civils de Lyon
NCT06063538 EARLY_Phase 1
Recruiting
Prevention of Postoperative Atrial Fibrillation (POAF) Using Intra-Pericardial Amiodarone
Enrollment
63 pts
Location
United States
Sponsor
University of Chicago
NCT06935513
Recruiting
Wearable Devices Empowering Active Health Initiatives for High-Risk Stroke Populations
Enrollment
300 pts
Location
China
Sponsor
Affiliated Hospital of Nantong...
NCT07210151
Recruiting
Anatomical Navigation for Guided Electrophysiology in AFL and AFib
Enrollment
50 pts
Location
Czechia
Sponsor
LUMA Vision Ltd.
NCT06938412
Recruiting
Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial Fibrillation
Enrollment
120 pts
Location
United States
Sponsor
Icahn School of Medicine at Mo...
NCT05836987 Phase 3
Recruiting
The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation
Enrollment
5,350 pts
Location
United States
Sponsor
Johns Hopkins University
NCT06542263
Recruiting
Clinical Study on the Effect of CPAP on AF Recurrence After Catheter Ablation in Patients with AF and OSA
Enrollment
224 pts
Location
China
Sponsor
Second Affiliated Hospital of ...
NCT05164107
Recruiting
Safety and Performance of a Pulsed Field Device for Global Mapping and Ablation of the Left Atrium for the Treatment of Atrial Fibrillation
Enrollment
175 pts
Location
Czechia
Sponsor
Kardium Inc.
NCT02138695
Recruiting
The Evaluation for Prognostic Factors After Catheter Ablation of Atrial Fibrillation: Cohort Study
Enrollment
3,100 pts
Location
South Korea
Sponsor
Yonsei University
NCT05664308
Recruiting
Interest of a Hybrid Connected Watch for Cardiac Rhythm Monitoring in Post-operative Cardiac Surgery
Enrollment
106 pts
Location
France
Sponsor
Nantes University Hospital
NCT06527105
Recruiting
Impact of Sleep Quality on Outcomes After Cardiac Surgery
Enrollment
100 pts
Location
India
Sponsor
Amrita Institute of Medical Sc...
NCT03907046 Phase 3
Recruiting
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
Enrollment
700 pts
Location
United States
Sponsor
Yale University
NCT06176131
Recruiting
The Cardio-share Telemedicine Cross-sector Collaboration Model for Managing Vulnerable Patients With Heart Failure
Enrollment
300 pts
Location
Denmark
Sponsor
University Hospital Bispebjerg...
NCT07523750
Recruiting
A Study of VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter in the Treatment of Participants With Persistent Atrial Fibrillation
Enrollment
466 pts
Location
United States
Sponsor
Biosense Webster, Inc.
NCT04766216
Recruiting
Warfarin Patient Self-management Implementation in the US Healthcare System
Enrollment
150 pts
Location
United States
Sponsor
University of Utah
NCT06475547
Recruiting
Inflammation and Postoperative Atrial Fibrillation in Cardiac Surgery
Enrollment
100 pts
Location
Denmark
Sponsor
Odense University Hospital
NCT05638841
Recruiting
Prospective Cohort Study of the Risk of Recurrent Atrial Fibrillation After Radiofrequency Ablation
Enrollment
300 pts
Location
China
Sponsor
Peking University Third Hospit...
NCT05371405
Recruiting
Machine Learning in Atrial Fibrillation
Enrollment
120 pts
Location
United States
Sponsor
Stanford University
NCT06110949
Recruiting
Thromboembolic Risk Assessment in Patients Admitted With Acute Medical Diseases to Conventional and At Home Hospitalization
Enrollment
1,953 pts
Location
Spain
Sponsor
Universidad Pública de Navarra
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology