State IL
Clinical Trials in Illinois
Illinois is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Illinois and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 417 actively recruiting studies with Illinois sites out of 417 registered in total. The busiest research areas in Illinois are Breast Cancer, Endometrial Cancer, Hypertension. Leading sponsors running trials in the state include University of Chicago, Northwestern University, University of Illinois at Chicago. By stage, Illinois trials break down as Phase 1 (66), Phase 2 (118), Phase 3 (105), Phase 4 (13).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Illinois
Frequently Asked Questions — Clinical Trials in Illinois
How many clinical trials are currently recruiting in Illinois?
ClinicalMetric currently tracks 417 actively recruiting clinical trials with at least one location in Illinois. The total number of registered studies—including active but not currently enrolling trials—is 417. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Illinois?
Illinois hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Endometrial Cancer, Hypertension, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Illinois serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Illinois?
To join a clinical trial in Illinois, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Illinois maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Illinois
NCT06880692 N/A
Recruiting
The Tick App: Changing Behaviors With Educational Messaging
Condition
Tick Bites
Enrollment
40,000 pts
Location
United States
Sponsor
University of Wisconsin, Madis
NCT06245109 Phase 4
Recruiting
Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthri...
Condition
Knee Osteoarthritis
Enrollment
180 pts
Location
United States
Sponsor
Northwestern University
NCT04166409 Phase 3
Recruiting
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients Wit...
Condition
Low Grade Astrocytoma
Enrollment
170 pts
Location
United States, Canada, Puerto Rico
Sponsor
National Cancer Institute (NCI
NCT07165028 Phase 3
Recruiting
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associ...
Condition
Metabolic Dysfunction-Associated Steatotic Liver Disease
Enrollment
4,500 pts
Location
United States, Argentina, Australia
Sponsor
Eli Lilly and Company
NCT07411300 N/A
Recruiting
Supporting Caregivers Following Mental Health Emergency Department Visits
Condition
Caregiver Participation
Enrollment
75 pts
Location
United States
Sponsor
Ann & Robert H Lurie Children'
NCT05762107 Phase 2
Recruiting
A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes
Condition
Type 1 Diabetes Mellitus With Hypoglycemia
Enrollment
186 pts
Location
United States, Canada
Sponsor
Zucara Therapeutics Inc.
NCT07672301 Phase 1, Phase 2
Recruiting
Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilate...
Condition
Total Knee Arthroplasty (TKA)
Enrollment
150 pts
Location
United States
Sponsor
University of Chicago
NCT06859164 Phase 2
Recruiting
Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptoma...
Condition
Knee Osteoarthritis
Enrollment
50 pts
Location
United States
Sponsor
University of Chicago
NCT06832189 Phase 1
Recruiting
EVR and EPO for Liver Transplant Tolerance
Condition
Liver Transplant
Enrollment
20 pts
Location
United States
Sponsor
National Institute of Allergy
NCT05915299 N/A
Recruiting
US National OCS Heart Perfusion (OHP) Registry
Condition
Heart Transplant
Enrollment
100,000 pts
Location
United States
Sponsor
TransMedics
NCT04176198 Phase 1, Phase 2
Recruiting
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Condition
Myelofibrosis
Enrollment
240 pts
Location
United States, Australia, Belgium
Sponsor
Sumitomo Pharma America, Inc.
NCT07288398 Phase 3
Recruiting
LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
Condition
Pulmonary Hypertension Associated With HFpEF
Enrollment
540 pts
Location
United States, Argentina, Austria
Sponsor
Tenax Therapeutics, Inc.
NCT05885698 N/A
Recruiting
MYLUNG Consortium Part 3: Observational Study
Condition
Carcinoma, Non-Small-Cell Lung
Enrollment
7,500 pts
Location
United States
Sponsor
US Oncology Research
NCT00009633 N/A
Recruiting
Follow-up Visit of High Risk Infants
Condition
Infant, Newborn
Enrollment
68,000 pts
Location
United States
Sponsor
NICHD Neonatal Research Networ
NCT06055608 Phase 2
Recruiting
Advancing Transplantation Outcomes in Children
Condition
Kidney Transplant
Enrollment
200 pts
Location
United States
Sponsor
National Institute of Allergy
NCT06059638 N/A
Recruiting
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
Condition
Hypertension
Enrollment
316 pts
Location
United States, Australia, Belgium
Sponsor
Orchestra BioMed, Inc
NCT07477691 Phase 4
Recruiting
Immune Modulation During Palynziq® Treatment in Adults (IMPALA)
Condition
Phenylketonuria
Enrollment
12 pts
Location
United States
Sponsor
BioMarin Pharmaceutical
NCT06393374 Phase 3
Recruiting
Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did ...
Condition
Triple-Negative Breast Cancer
Enrollment
1,530 pts
Location
United States, Argentina, Australia
Sponsor
Merck Sharp & Dohme LLC
NCT07478926 N/A
Recruiting
Flow Detection in Open and Closed Shunt Valve Periods
Condition
Hydrocephalus
Enrollment
55 pts
Location
United States
Sponsor
Rhaeos, Inc.
NCT05868226 Phase 1, Phase 2
Recruiting
PRE-ISPY Phase I/II Oncology Platform Program
Condition
HER2-positive Breast Cancer
Enrollment
280 pts
Location
United States
Sponsor
QuantumLeap Healthcare Collabo
NCT03595917 Phase 1
Recruiting
ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CML
Condition
B-cell Acute Lymphoblastic Leukemia
Enrollment
40 pts
Location
United States
Sponsor
Marlise Luskin, MD
NCT06591091 Phase 2
Recruiting
Clemastine for Improving White Matter and Boosting Antidepressant Response in La...
Condition
Depression
Enrollment
80 pts
Location
United States
Sponsor
University of Illinois at Chic
NCT04228978 N/A
Recruiting
Promote Weight Loss in Obese Peripheral Artery Disease (PAD) Patients to Prevent...
Condition
Peripheral Artery Disease
Enrollment
212 pts
Location
United States
Sponsor
Northwestern University
NCT01524276 N/A
Recruiting
Product Surveillance Registry
Condition
Cardiac Rhythm Disorders
Enrollment
100,000 pts
Location
United States, Argentina, Australia
Sponsor
Medtronic
NCT07288216 Phase 2
Recruiting
Transition to KPL-387 Monotherapy Dosing & Administration Study
Condition
Recurrent Pericarditis
Enrollment
80 pts
Location
United States, Canada, France
Sponsor
Kiniksa Pharmaceuticals Intern
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology