State IL
Clinical Trials in Illinois
Illinois is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Illinois and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 398 actively recruiting studies with Illinois sites out of 398 registered in total. The busiest research areas in Illinois are Schizophrenia, Obesity, Breast Cancer. Leading sponsors running trials in the state include University of Chicago, Northwestern University, University of Illinois Chicago. By stage, Illinois trials break down as Phase 1 (55), Phase 2 (104), Phase 3 (106), Phase 4 (15).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Illinois
Frequently Asked Questions — Clinical Trials in Illinois
How many clinical trials are currently recruiting in Illinois?
ClinicalMetric currently tracks 398 actively recruiting clinical trials with at least one location in Illinois. The total number of registered studies—including active but not currently enrolling trials—is 398. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Illinois?
Illinois hosts clinical trials across a broad range of medical conditions, including Schizophrenia, Obesity, Breast Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Illinois serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Illinois?
To join a clinical trial in Illinois, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Illinois maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Illinois
NCT05726292 Phase 2
Recruiting
A Study of Enzalutamide Plus the Glucocorticoid Receptor Antagonist Relacorilant...
Condition
Prostate Cancer
Enrollment
90 pts
Location
United States
Sponsor
University of Chicago
NCT06241456 Phase 1
Recruiting
FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibod...
Condition
Advanced Solid Tumor
Enrollment
351 pts
Location
United States
Sponsor
Fate Therapeutics
NCT06472245 Phase 3
Recruiting
Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung...
Condition
Patients With Non-Small Cell Lung Cancer
Enrollment
363 pts
Location
United States, Belgium, Canada
Sponsor
OSE Immunotherapeutics
NCT06087029 N/A
Recruiting
IMPRoving Outcomes in Vascular DisEase - Aortic Dissection
Condition
Type B Aortic Dissection
Enrollment
1,100 pts
Location
United States, Canada
Sponsor
Duke University
NCT06390345 N/A
Recruiting
Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise ...
Condition
Chronic Obstructive Pulmonary Disease
Enrollment
400 pts
Location
United States
Sponsor
Seattle Institute for Biomedic
NCT07266831 Phase 2, Phase 3
Recruiting
A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have No...
Condition
Human Immunodeficiency Virus Type 1 (HIV-1) Infection
Enrollment
570 pts
Location
United States, Argentina, Canada
Sponsor
Merck Sharp & Dohme LLC
NCT03797495 N/A
Recruiting
Study of Individuals Affected With Hypoplasminogenemia
Condition
Plasminogen Deficiency
Enrollment
100 pts
Location
United States, Argentina, Australia
Sponsor
Indiana Hemophilia &Thrombosis
NCT07323862 N/A
Recruiting
Assessment of a Method to Improve Cochlear Implant Users' Speech Perception in N...
Condition
Cochlear Implant Users
Enrollment
25 pts
Location
United States
Sponsor
University of Illinois at Urba
NCT05264051 N/A
Recruiting
MAsS Scan as a Predictor of Morbidity and Mortality in Patients With Liver Disea...
Condition
Liver Diseases
Enrollment
1,200 pts
Location
United States
Sponsor
University of Chicago
NCT06918041 N/A
Recruiting
FiberLocker® System Augmentation of Rotator Cuff Repairs
Condition
Rotator Cuff Tear
Enrollment
60 pts
Location
United States
Sponsor
ZuriMED Technologies Inc.
NCT04683653 Phase 1, Phase 2
Recruiting
Study of Pelvic Hypofractionated Radiotherapy in Endometrial Cancer
Condition
Endometrial Cancer
Enrollment
100 pts
Location
United States
Sponsor
University of Chicago
NCT06639503 Phase 1
Recruiting
Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau
Condition
Tibial Plateau Fractures
Enrollment
38 pts
Location
United States
Sponsor
University of Chicago
NCT06095505 Phase 2
Recruiting
A Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer
Condition
Small Cell Lung Cancer
Enrollment
120 pts
Location
United States
Sponsor
Puma Biotechnology, Inc.
NCT05654922 Phase 3
Recruiting
Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progress...
Condition
Pre-Bronchiolitis Obliterans Syndrome
Enrollment
100 pts
Location
United States
Sponsor
Renovion, Inc.
NCT07276373 Phase 1, Phase 2
Recruiting
Two Part Study of Nenocorilant Combined With Nivolumab in Patients With Advanced...
Condition
Neoplasms
Enrollment
50 pts
Location
United States
Sponsor
Corcept Therapeutics
NCT07005505 N/A
Recruiting
Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous ...
Condition
Spontaneous Breathing Trial in ICU
Enrollment
880 pts
Location
United States
Sponsor
Rush University Medical Center
NCT05489705 N/A
Recruiting
A Prospective Registry Study to Assess Real-world Patient Characteristics, Treat...
Condition
Obstructive Hypertrophic Cardiomyopathy
Enrollment
1,700 pts
Location
United States, Austria, Czechia
Sponsor
Bristol-Myers Squibb
NCT05566769 N/A
Recruiting
Performance and Safety of a Digital Tool for Unsupervised Self-assessment of NMO...
Condition
Neuromyelitis Optica
Enrollment
103 pts
Location
United States, France, Germany
Sponsor
Ad scientiam
NCT07464353 N/A
Recruiting
xDot Access Management System Early Feasibility Study
Condition
Vascular Closure Devices
Enrollment
30 pts
Location
United States
Sponsor
xDot Medical, Inc
NCT05107674 Phase 1
Recruiting
A Study of NX-1607 in Adults With Advanced Malignancies
Condition
Ovarian Cancer, Epithelial
Enrollment
345 pts
Location
United States, United Kingdom
Sponsor
Nurix Therapeutics, Inc.
NCT06341023 N/A
Recruiting
Functional Balance Intervention in Multiple Sclerosis
Condition
Multiple Sclerosis
Enrollment
120 pts
Location
United States
Sponsor
University of Illinois Chicago
NCT01644903 N/A
Recruiting
Proteogenomic Monitoring and Assessment of Liver Transplant Recipients
Condition
Liver Transplant
Enrollment
1,000 pts
Location
United States
Sponsor
Northwestern University
NCT07536269 Phase 2
Recruiting
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Crinecerfont in P...
Condition
Congenital Adrenal Hyperplasia
Enrollment
20 pts
Location
United States
Sponsor
Neurocrine Switzerland GmbH
NCT03527420 N/A
Recruiting
DNA Methylation and Vascular Function
Condition
Obesity
Enrollment
80 pts
Location
United States
Sponsor
University of Illinois Chicago
NCT04098146 N/A
Recruiting
Registry to Collect Data on Patients Undergoing Segmental Mandibular Defect Reco...
Condition
Mandibular Reconstruction
Enrollment
300 pts
Location
United States, Germany, Japan
Sponsor
AO Innovation Translation Cent
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology