Mayo Clinic

Mayo Clinic is a nonprofit academic medical center headquartered in Rochester, Minnesota, with major campuses in Phoenix, Arizona and Jacksonville, Florida. It is consistently ranked as one of the top hospitals in the United States and is among the most prolific academic sponsors of clinical trials, with investigator-initiated studies across virtually every medical specialty. Mayo Clinic's mission — "the needs of the patient come first" — is reflected in its integrated model of care and research, where clinical trial enrollment is embedded into routine specialty practice.

Mayo Clinic's research enterprise spans the Mayo Clinic Comprehensive Cancer Center (NCI-designated), the Mayo Clinic Heart and Vascular Center, the Mayo Clinic Center for Individualized Medicine (precision oncology and pharmacogenomics), the Mayo Clinic Alix School of Medicine research programs, and the Division of Clinical Trials and Biostatistics. Mayo runs an estimated 8,000+ clinical studies at any given time, including observational, registry-based, and interventional trials across all phases.

Mayo Clinic has particular research depth in rare hematologic malignancies — including amyloidosis, Waldenstrom's macroglobulinemia, and POEMS syndrome — due to specialized expertise built over decades. The institution also leads national trials in platelet disorders (including ITP), polycystic kidney disease, orthopedic surgery outcomes, gastroenterology (Barrett's esophagus, eosinophilic esophagitis), and neurological conditions including epilepsy surgery and ALS natural history studies.

Frequently Asked Questions — Mayo Clinic