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Mayo Clinic

Total Trials

Recruiting

Phases

Phase 2, Phase 1, Phase 4, EARLY_Phase 1

Conditions studied: Opioid-Induced Esophageal Dysfunction Fractures Lymphoma, Non-Hodgkin Leukemia, Lymphocytic, Chronic, B-Cell Lymphoma, B-Cell Monoclonal B-Cell Lymphocytosis Multiple Myeloma Hearing Loss Atypical Alzheimer's Disease Logopenic Progressive Aphasia (LPA)

Mayo Clinic is a nonprofit academic medical center headquartered in Rochester, Minnesota, with major campuses in Phoenix, Arizona and Jacksonville, Florida. It is consistently ranked as one of the top hospitals in the United States and is among the most prolific academic sponsors of clinical trials, with investigator-initiated studies across virtually every medical specialty. Mayo Clinic's mission — "the needs of the patient come first" — is reflected in its integrated model of care and research, where clinical trial enrollment is embedded into routine specialty practice.

Mayo Clinic's research enterprise spans the Mayo Clinic Comprehensive Cancer Center (NCI-designated), the Mayo Clinic Heart and Vascular Center, the Mayo Clinic Center for Individualized Medicine (precision oncology and pharmacogenomics), the Mayo Clinic Alix School of Medicine research programs, and the Division of Clinical Trials and Biostatistics. Mayo runs an estimated 8,000+ clinical studies at any given time, including observational, registry-based, and interventional trials across all phases.

Mayo Clinic has particular research depth in rare hematologic malignancies — including amyloidosis, Waldenstrom's macroglobulinemia, and POEMS syndrome — due to specialized expertise built over decades. The institution also leads national trials in platelet disorders (including ITP), polycystic kidney disease, orthopedic surgery outcomes, gastroenterology (Barrett's esophagus, eosinophilic esophagitis), and neurological conditions including epilepsy surgery and ALS natural history studies.

Frequently Asked Questions — Mayo Clinic

What rare diseases does Mayo Clinic specialize in researching?

Mayo Clinic has internationally recognized expertise in several rare conditions that are heavily researched through clinical trials. In hematology, Mayo is the world's leading center for systemic amyloidosis research (both AL amyloidosis and ATTR amyloidosis), polycythemia vera and essential thrombocythemia, and conditions like Waldenstrom's macroglobulinemia and POEMS syndrome. In gastroenterology, Mayo leads research in eosinophilic esophagitis and achalasia. Neurology rare disease trials include primary orthostatic tremor, stiff person syndrome, and various forms of inherited ataxia. The rarity of these conditions often makes Mayo one of only a handful of centers where trials are available.

Does Mayo Clinic conduct clinical trials in all three of its campuses?

Yes. Clinical trials are active across Mayo Clinic's Rochester (Minnesota), Phoenix (Arizona), and Jacksonville (Florida) campuses, though specific trial availability varies by location. Some investigator-initiated studies are site-specific, while multicenter trials — including NCI cooperative group studies — are open at all three sites simultaneously. Patients can search Mayo's trial database at www.mayoclinic.org/clinical-trials and filter by campus location. Mayo also participates in trials at affiliated community health system partners through the Mayo Clinic Health System across the upper Midwest.

Can patients travel to Mayo Clinic for a clinical trial and receive coordinated care?

Mayo Clinic is specifically designed to provide coordinated, multidisciplinary care to patients who travel from other states or countries. For clinical trial patients, this includes scheduling all trial-related appointments — including imaging, labs, infusions, and specialist consultations — in a condensed time frame to minimize travel burden. Patient-friendly accommodations and logistics support (shuttle service, hotel affiliates, on-campus lodging) are available. International patients can access the Mayo Clinic International Program for visa assistance and care coordination. Travel costs are not typically covered by trial protocols, but Mayo's financial counselors can help identify assistance programs.

Mayo Clinic

Frequently Asked Questions — Mayo Clinic

Clinical Trials by Mayo Clinic

Effect of Opioid Cessation on Opioid-Induced Esophageal Dysfunction

Virtual Reality in Reducing Acute Orthopedic Pain

Family Study of Lymphoproliferative Disorders

AI Noise Reduction in Phonak Hearing Aids

Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study

Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS)

Mindfulness and Meditation Based Lactation Education on Maternal Breastmilk in the Neonatal ICU

Continuous Glucose Monitor for Mayo Clinic Advanced Care at Home Patients

Accuracy of 18F-rhPSMA-7.3 PET/ MRI for Prediction of Lymph Node Metastasis in Localized High-Risk Prostate Cancer

A Study Investigating the Impact of IMT With CR On Exercise Responses In HF

Implications of the Human Microbiota for Health and Disease

Multi-Cancer Detection Observational Cohort Study

Pre-transplant Health Coaching to Improve Patient-Reported Outcomes in Lung Transplant Candidates

ATM-Inhibitor WSD0628 in Combination With Radiation Therapy for Treatment of Recurrent High-Grade Glioma

Mechanisms of Anabolic Resistance in Older Humans

MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers

Patient Derived Preclinical Models

Group Cognitive Behavior Sessions (CBCSM) to Decrease Distress in Cancer Patients

A Mindfulness-Based Stress Reduction Program for Improving Mental Health Outcomes for Underserved Cancer Patients in Minnesota

Preoperative Hypofractionated Radiotherapy With FOLFOX for Esophageal or Gastroesophageal Junction Adenocarcinoma

A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear Palsy

Treatment of Upper Gastrointestinal Symptoms Using Hypnotherapy Sessions

Family-Based Financial Incentives Intervention for Smoking Cessation

Evaluation of Alternative Site Goserelin Acetate Injection for Ovarian Function Suppression (OFS) in Local and Locally Advanced Premenopausal Hormone Receptor Positive Breast Cancer Patients

Low Sodium Oxybate in Patients With Idiopathic Hypersomnia

Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery

68Ga-FAPI-46 PET/CT for Assessing Small Bowel Fibrostenosis in Crohn's Disease

Immune Profile of Acute Myeloid Leukemia Patients Receiving Azacitidine Plus Venetoclax Induction Chemotherapy

A Study Comparing Shoulder Replacement Techniques For Patients With Shoulder Arthritis And An Intact Rotator Cuff

Novel Pilot Study to Treat Symptoms of IBS With Diarrhea Using Combination Therapy of a Low-FODMAP Diet and a Neuromodulator

Obinutuzumab in Treatment of Fibrillary Glomerulonephritis

Exploring the Effect of Calaspargase Pegol on the Coagulation System in Pediatric Acute Lymphoblastic Leukemia (ALL) Patients: Pilot Study

Study of Human Brain-Gut Axis and Gut Microbiome in Patients With Brain Lesions - Repository for Neuroscience Research

Evaluation of Hypertension Management and Cardiovascular Adverse Event Prevention in Patients With B-cell Malignancies Undergoing Treatment With Bruton Tyrosine Kinase Inhibitors, the HALT Study

Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting

Diaphragmatic Breathing for the Treatment of Bloating and Distension

Using Facebook to Support Opioid Recovery Among American Indian Women

Adaptive Radiation Therapy (ART) Stereotactic Ablative Body Radiotherapy (SABR) for Primary Localized Prostate Cancer

Acceptance and Commitment Therapy for the Improvement of Cancer Distress in Patients With Incurable Cancers, ACT-C Trial

Using Induced-Pluripotent Stem Cells to Model Cancer Therapy-Related Adverse Events

Screening and Staging of Benign vs Malignant Pelvic Abnormalities

Dietary and Topical Magnesium Replacement or Supplementation in Patients With Lymphoma

Intravenous Ketamine for Treatment-Resistant Depression

Development of Patient Derived Xenografts (PDX) in Patients With Breast Cancer

Enhancing Brain And Mental Health Through Breathing Practice

Addressing Disparities in Colorectal Cancer Screening in Black and Underserved Phoenix Communities

A Study of Genetic Influence on LDL Hyper-responsiveness in Patients Following a Ketogenic Diet

Estimation of Biomechanical Aortic Wall Properties in Healthy and Aneurysmal Aortas Using Novel Imaging Techniques

Flyte Device for Improving Urinary Incontinence Among Endometrial and Cervical Cancer Survivors Who Have Undergone Radiation Therapy

A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

Novel Treatment for Rotator Cuff Tears

A Prospective Observational Study of Foam Sclerotherapy .

Intravenous Vesicular Stomatitis Virus in Patients With Peripheral T-cell Lymphoma

Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain

Exploration of HRQOL and Urinary Outcomes Following Partial Cystectomy

Real-Time Cholangioscopy Artificial Intelligence Evaluation of Biliary Strictures

Examination of the Impact of CalmiGo's Stress Management Device on Vascular Heath and Cardiovascular Disease Risk.

Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those Using CGRP Targeting Preventive Medications

Intravital Microscopy in Human Solid Tumors

Ultrasound-Guided Core Needle Biopsy to Stage Urothelial Carcinoma of the Bladder (US UCB)

Ommaya Reservoir Placement for Brain Tumor Biomarker Access

Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial

The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity

Pain Control for Undergoing Costal Cartilage Harvesting

Gynecologic Extramammary Paget's Disease

Accelerated Resolution Therapy for Early Maladaptive Grief

VSV-IFNβ-NIS With Ipilimumab and Nivolumab for the Treatment of Advanced or Metastatic Clear Cell Renal Cell Carcinoma

Erector Spinae Plane Block Versus Trigger Point Injection for Chronic Thoracic Myofascial Pain