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Mayo Clinic

Total Trials

Recruiting

Phases

EARLY_Phase 1, Phase 3, Phase 1, Phase 2, Phase 1, Phase 2, Phase 4

Conditions studied: Autosomal Dominant Polycystic Kidney Disease Colorectal Carcinoma Lynch Syndrome Barrett Esophagus Esophageal Adenocarcinoma Critical Illness COVID-19 PICS Cognitive Impairment Mental Health Impairment

Mayo Clinic is a nonprofit academic medical center headquartered in Rochester, Minnesota, with major campuses in Phoenix, Arizona and Jacksonville, Florida. It is consistently ranked as one of the top hospitals in the United States and is among the most prolific academic sponsors of clinical trials, with investigator-initiated studies across virtually every medical specialty. Mayo Clinic's mission — "the needs of the patient come first" — is reflected in its integrated model of care and research, where clinical trial enrollment is embedded into routine specialty practice.

Mayo Clinic's research enterprise spans the Mayo Clinic Comprehensive Cancer Center (NCI-designated), the Mayo Clinic Heart and Vascular Center, the Mayo Clinic Center for Individualized Medicine (precision oncology and pharmacogenomics), the Mayo Clinic Alix School of Medicine research programs, and the Division of Clinical Trials and Biostatistics. Mayo runs an estimated 8,000+ clinical studies at any given time, including observational, registry-based, and interventional trials across all phases.

Mayo Clinic has particular research depth in rare hematologic malignancies — including amyloidosis, Waldenstrom's macroglobulinemia, and POEMS syndrome — due to specialized expertise built over decades. The institution also leads national trials in platelet disorders (including ITP), polycystic kidney disease, orthopedic surgery outcomes, gastroenterology (Barrett's esophagus, eosinophilic esophagitis), and neurological conditions including epilepsy surgery and ALS natural history studies.

Frequently Asked Questions — Mayo Clinic

What rare diseases does Mayo Clinic specialize in researching?

Mayo Clinic has internationally recognized expertise in several rare conditions that are heavily researched through clinical trials. In hematology, Mayo is the world's leading center for systemic amyloidosis research (both AL amyloidosis and ATTR amyloidosis), polycythemia vera and essential thrombocythemia, and conditions like Waldenstrom's macroglobulinemia and POEMS syndrome. In gastroenterology, Mayo leads research in eosinophilic esophagitis and achalasia. Neurology rare disease trials include primary orthostatic tremor, stiff person syndrome, and various forms of inherited ataxia. The rarity of these conditions often makes Mayo one of only a handful of centers where trials are available.

Does Mayo Clinic conduct clinical trials in all three of its campuses?

Yes. Clinical trials are active across Mayo Clinic's Rochester (Minnesota), Phoenix (Arizona), and Jacksonville (Florida) campuses, though specific trial availability varies by location. Some investigator-initiated studies are site-specific, while multicenter trials — including NCI cooperative group studies — are open at all three sites simultaneously. Patients can search Mayo's trial database at www.mayoclinic.org/clinical-trials and filter by campus location. Mayo also participates in trials at affiliated community health system partners through the Mayo Clinic Health System across the upper Midwest.

Can patients travel to Mayo Clinic for a clinical trial and receive coordinated care?

Mayo Clinic is specifically designed to provide coordinated, multidisciplinary care to patients who travel from other states or countries. For clinical trial patients, this includes scheduling all trial-related appointments — including imaging, labs, infusions, and specialist consultations — in a condensed time frame to minimize travel burden. Patient-friendly accommodations and logistics support (shuttle service, hotel affiliates, on-campus lodging) are available. International patients can access the Mayo Clinic International Program for visa assistance and care coordination. Travel costs are not typically covered by trial protocols, but Mayo's financial counselors can help identify assistance programs.

Mayo Clinic

Frequently Asked Questions — Mayo Clinic

Clinical Trials by Mayo Clinic

Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

A Study of Healthy Microbiome, Healthy Mind

Optimizing Brain Stimulation Parameters

Sequential Treatments or Combinations Including Dasatinib, Quercetin, Fisetin and/or Temozolomide for the Treatment of Previously Treated Glioma With Residual Disease

Sevoflurane/Dexmedetomidine vs. Isoflurane for Pediatric Emergence Delirium

SBRT Versus Hypofractionated Radiotherapy for Biochemically Recurrent or Oligometastatic Prostate Adenocarcinoma

Breast Cancer, Reasoning, and Activity Intervention

BLOOM: Pragmatic Feasibility Trial

App-Based Optimization of Long-Term CPAP Adherence and Quality of Life

Use of [18F] Fluoroethyl-L-tyrosine PET/MRI for Identifying Small Functional Pituitary Adenomas

Lumbar Vein Embolization for Chronic Headaches With Nutcracker Physiology

Efineptakin Alfa and Pembrolizumab for the Treatment of Recurrent Glioblastoma

Fucoidan for Preventing Chemotherapy-Related Fatigue in Patients With Gastrointestinal or Gynecological Cancer

Effect of Prolonged Fasting Time on Gastric Residual Volume in Patients Taking GLP1 Receptor Agonists

Deciphering Preserved Autonomic Function After Spinal Cord Injury

GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma

Avacopan in Crescentic Immunoglobulin A Nephropathy (IgAN)

Prehabilitation With Aerobic and Resistance Exercise for Improving Physical Fitness and Quality of Life Outcomes in Older Patients Undergoing CAR-T Therapy for Relapsed or Refractory Multiple Myeloma

An Imaging Agent (Pafolacianine) for Identifying Lesions in Pediatric Patients With Primary or Metastatic Solid Tumors

Neostigmine and Glycopyrrolate for the Treatment of Headache After Dural Puncture

Ex Vivo Expansion (ACT-X)

Collecting Patient-Reported Experiences With Radiation Dermatitis in Breast Cancer Patients Undergoing Radiotherapy

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

Concomitant Renal and Urinary Bladder Allograft Transplantation

A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults

Scoliosis Survey to Development Treatment Decision Tool

Adult Spinal Deformity Surgery Real-World Functional Activity

A Study of Live Tumor Fragments of Surgical Resections

Family-Based Financial Incentives Intervention for Smoking Cessation

A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

Collection of Specimens and Clinical Data for Patients With Recurrent or Metastatic Breast Cancer or Male Breast Cancer

Effect of Sacubitril-Valsartan on Cardiac Structure and Function

Using Induced-Pluripotent Stem Cells to Model Cancer Therapy-Related Adverse Events

Under-Resourced Adults With Chronic Pain eHealth Study

Study of Human Brain-Gut Axis and Gut Microbiome in Patients With Brain Lesions - Repository for Neuroscience Research

Insulin and Insulin Pulses During Fasting

Molecular Detection of Advanced Neoplasia in Pancreatic Cysts

Primary Breast Oligoprogressive Sites Treated With Radiotherapy to Obviate the Need to Change Systemic Therapy

Weight Loss Through Mayo Clinic Diet

Implications of the Human Microbiota for Health and Disease

Ambient Sensing Room to Detect Early Signs of Adverse Events in Hospitalized Patients With Cancer

Post-sleeve Gastrectomy Gastroesophageal Reflux Disease Prediction

Hypofractionated Radiotherapy Before or After Breast Surgery for Treatment of Patients With Non-Metastatic Breast Cancer

Fuzzy Wale Compression Stockinet to Promote Healing Following Transtibial Amputation for Peripheral Arterial Disease

CAMEO-FONTAN -Dapagliflozin in the Failing Fontan Circulation

Neurotization of the Nipple Areolar Complex to Restore Sensation for Patients With Breast Cancer Undergoing Nipple Sparing Mastectomy and Reconstruction

Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) Combined With Immune Checkpoint Inhibition After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancer

Dietary and Topical Magnesium Replacement or Supplementation in Patients With Lymphoma

A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD

The Effects of Sleep on Human Microbiota: Implications for Health and Disease

Study of Transcranial Direct Current Stimulation to Treat Epilepsy

The Use of Ultrasound in Assessing Post-prostatectomy Erectile Dysfunction

Pre-myeloid Cancer and Bone Marrow Failure Clinic Study

Evaluation of Plasma Renin Concentrations in Cardiac Surgery

Risk Stratified De-escalated Hormone Therapy With Radiation Therapy for the Treatment of Prostate Cancer

A Study of Endoscopic Sleeve Gastroplasty for Obesity in Ulcerative Colitis

CD19-Directed CAR-T Cell Therapy for the Treatment of Relapsed/Refractory B Cell Malignancies

Dynamics of Organ Damage and Immune Exhaustion During Sepsis

A Study Of Starting Strength Barbell Training

Radioembolization With Tremelimumab and Durvalumab for Locally Advanced Unresectable or Oligo-Metastatic Intrahepatic Cholangiocarcinoma

A Study of AI in Cardiac Transplant in Echocardiographic Analysis (ORACLE)

Feasibility of Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

Hematopoiesis in MBL and CLL Versus Healthy Age-Matched Control Subjects

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

Mechanisms of Anabolic Resistance in Older Humans

Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy

Thalamus Seizure Detection With a Deep Brain Stimulator System

Understanding Mechanisms of Normal and Disordered Defecation

Cardiac Rehabilitation Mobile-Health Fall Risk Prevention Intervention

Alternate Doses and Dosing Schedules of Belantamab Mafodotin for Treatment of Triple-Class Refractory Multiple Myeloma

Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables

MUC1-Activated T Cells for the Treatment of Relapsed and Resistant Ovarian Cancer

Group Cognitive Behavior Sessions (CBCSM) to Decrease Distress in Cancer Patients

Breastmilk in Response to a Bout of Exercise

Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer