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Medical Condition

critical illness

Total Trials

29

Recruiting Now

29

Trial Phases

Phase 1, Phase 2, Phase 4, Phase 1

ClinicalMetric tracks all active clinical trials for critical illness sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — critical illness Clinical Trials

How many clinical trials are currently recruiting for critical illness?

ClinicalMetric currently tracks 29 actively recruiting clinical trials for critical illness, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 29. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for critical illness?

critical illness research spans Phase 1 (2 trials), Phase 2 (1 trial), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a critical illness clinical trial?

Eligibility criteria for critical illness trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

2

Phase 2

1

Phase 4

1

Top Sponsors

Duke University 3 trials

Karolinska University Hospital 2 trials

Children's Hospital of Fudan University 2 trials

Matthew Modes 1 trial

Tel-Aviv Sourasky Medical Center 1 trial

Recruiting Clinical Trials

The Family Perspectives Project Pilot Trial

Evaluation of Fentanyl Transdermal Patch Absorption in Hemodynamically Unstable ICU Patients.

Tel-Aviv Sourasky Medical Cent...

REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19

Duke University

Timing of Renal Replacement Therapy in the Critically Ill Patients

Karolinska University Hospital

VENtilation Modalities During Transport of PostoperatIve CRITically Ill Patients to the ICU

Societa Italiana Anestesia Ana...

NCT07101640 Phase 1, Phase 2

PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia

Duke University

IL-6 and Hemogram-Derived Inflammatory Indices for Mortality Prediction in Postoperative ICU Patients

Turkey (Türkiye)

Ezgi Günaydın

Trial on the Impact of Indirect Calorimetry-Guided Nutritional Support on Patient-Centered Outcomes in Critically Ill Patients - The OPTICal Study

Clinical Application of Listening to Music to Prevent Delirium in the Intensive Care Unit

HOSPITAL BRITANICO DE BUENOS A...

EIT-Guided Respiratory Physiotherapy for Prolonged Mechanical Ventilation (PMV)

Capital Medical University

Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure

University Hospital Ostrava

Treatment Strategy of Human Gamma Globulin on the Therapy for Intensively Ill Children With Inflammatory Storm

Children's Hospital of Fudan U...

Ultrasound Detection of Body Composition in Critical Care

Ain Shams University

Factors Influencing Outcomes in ECMO and Impella Patients: Metabolic and Thyroid Hormone Dynamics

Gottsegen National Cardiovascu...

Endogenous Energy Production in Critically Ill Patients

Karolinska University Hospital

Medical Honey for Wound Treatment in Intensive Care. (MICARéa) Randomized, Controlled, Single-center Pilot Study.

University Hospital, Angers

Impact of Echocardiography on Management of Critically Ill Neonates

Sahar Abozkaly Mahmoud

Early Severe Illness TrAnslational BioLogy InformaticS in Humans

London Health Sciences Centre ...

The VIP3 (Very Old Intensive Care Patients) Study: Family Involvement in Treatment Decisions for Old ICU Patients

St George's, University of Lon...

Immune Modulation by Exosomes in COVID-19

University of Ulm

Life Sustaining Treatments in Critically Ill Children

Göteborg University

A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children

Children's Hospital of Fudan U...

Metabolic and Functional Study of γδ T Cells in Critically Ill Patients

Union Hospital, Tongji Medical...

NCT07407400 Phase 4

Lemborexant for Sleep and Delirium Prevention in Elderly ICU Patients

Mahidol University

Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery

Duke University

Establishing Normative Data for Pupillometer Assessments in Neuro-Intensive Care

University of Texas Southweste...

Humidification Effects on Airway Complications and Clinical Outcomes in Trauma ICU Patients on Mechanical Ventilation

Assiut University

NCT05453695 Phase 1

Intravenous DNase I for the Treatment of Sepsis (IDEALSepsisI)

McMaster University

The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial

Siriraj Hospital

Related Conditions

respiratory failure (3) sepsis (3) covid 19 (2) postoperative complications (2) inflammation (2) delirium (2) prolonged mechanical ventilation (2) family support (1) physician patient relations (1) pain management (1) icu acquired weakness (1) pics (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology