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Medical Condition

critical illness

Total Trials

26

Recruiting Now

26

Trial Phases

Phase 2, Phase 3, Phase 2, Phase 3

ClinicalMetric tracks all active clinical trials for critical illness sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — critical illness Clinical Trials

How many clinical trials are currently recruiting for critical illness?

ClinicalMetric currently tracks 26 actively recruiting clinical trials for critical illness, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 26. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for critical illness?

critical illness research spans Phase 2 (2 trials), Phase 3 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a critical illness clinical trial?

Eligibility criteria for critical illness trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 2

2

Phase 3

2

Top Sponsors

University of Liege 1 trial

Chulalongkorn University 1 trial

Australian and New Zealand Intensive Care Research Centre 1 trial

KU Leuven 1 trial

Universidad Autonoma del Estado de Mexico 1 trial

Recruiting Clinical Trials

Incidence of Episodes of (Dis)Connected Consciousness Among Emergency Patients Admitted in the Resuscitation Room

University of Liege

ICU Fluid Utilization Survey in Southeast Asia

Chulalongkorn University

NCT04608630 Phase 2

Bone Loss Prevention With Zoledronic Acid or Denosumab in Critically Ill Adults

Australia, New Zeala...

Australian and New Zealand Int...

Locomotor Muscle Oxygenation and Activation During Acute Interval Compared to Constant-load Bed-cycling Exercise

Physiological Changes in Adult Intensive Care Patients Following Contact With Their Primary Caregiver

Universidad Autonoma del Estad...

IMMUNOREA - Immunological and Inflammatory Determinants Associated With the Prognosis of Intensive Care Patients

Assistance Publique - Hôpitaux...

COPM-Based Goal Setting Strategies in the PICU

Samsung Medical Center

Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle

Yale University

Scores in Critically Ill Patients After Craniotomy

Beijing Tiantan Hospital

The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial

Siriraj Hospital

Gastric Emptying and Enteral Nutrition Tolerance According to Vasopressor Dose in ICU Patients

Turkey (Türkiye)

Başakşehir Çam & Sakura City H...

MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Mitigate ICU Acquired Weakness in Medical ICU Patients

Health Discovery Labs

NIBP Validation Study

Philips Clinical & Medical Aff...

Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure

University Hospital Ostrava

Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients

The Institute of Molecular and...

Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )

Universität Münster

Therapeutic Drug Monitoring of Beta-lactams and Renal Hyperclearance in Patients Admitted to Intensive Care for Acute Brain Injury

Centre Hospitalier Universitai...

NCT03188796 Phase 3

The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients

Austria, Belgium, Ge...

Medical University of Graz

Non-Invasive Blood Pressure Monitoring in ICU Patients Using the DARE Device

Centre Hospitalier de Saint-De...

NCT06223828 Phase 2, Phase 3

Azithromycin for Critical Asthma - Pediatrics

Johns Hopkins All Children's H...

Pervasive Sensing and AI in Intelligent ICU

University of Florida

Effectiveness of a Structured Multidimensional Tele-rehabilitation Intervention in Cardiac Patients With Post-Intensive Care Syndrome (CARDIO-PICS)

Fondazione Don Carlo Gnocchi E...

The Effect of a 6-month Dietitian-tailored Nutrition Intervention to Patients With Critical Illness (DETAIL)

University Hospital of North N...

Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery

Duke University

Clinical Application of Listening to Music to Prevent Delirium in the Intensive Care Unit

HOSPITAL BRITANICO DE BUENOS A...

The Effect of the Timing of Supplemental Parenteral Nutrition on the Prognosis of Critically Ill Patients (T-SPN)

Related Conditions

delirium (2) near death experience (1) consciousness loss of (1) quality of life (1) emergencies (1) osteoporosis (1) intensive care unit acquired weakness (1) critically ill patients (1) intensive care patients (1) critical illness requiring intensive care sepsis (1) critical illness requiring intensive care acute brain injury (1) critical illness requiring intensive care major surgery (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology