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Medical Condition

critical illness

Total Trials

22

Recruiting Now

22

Trial Phases

Phase 3, Phase 2, Phase 1, Phase 2

ClinicalMetric tracks all active clinical trials for critical illness sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — critical illness Clinical Trials

How many clinical trials are currently recruiting for critical illness?

ClinicalMetric currently tracks 22 actively recruiting clinical trials for critical illness, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 22. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for critical illness?

critical illness research spans Phase 1 (2 trials), Phase 2 (3 trials), Phase 3 (2 trials), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a critical illness clinical trial?

Eligibility criteria for critical illness trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

2

Phase 2

3

Phase 3

2

Phase 4

1

Top Sponsors

Region Stockholm 2 trials

Australian and New Zealand Intensive Care Research Centre 2 trials

Samsung Medical Center 1 trial

Technical University of Munich 1 trial

Duke University 1 trial

Recruiting Clinical Trials

Peripheral pULSe Assessment and Arterial pRessure (PULSAR)

Region Stockholm

NCT06526533 Phase 3

RECOMMEND Platform Trial

Australian and New Zealand Int...

COPM-Based Goal Setting Strategies in the PICU

Samsung Medical Center

Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness

Austria, Germany

Technical University of Munich

REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19

Duke University

Developing Strategies to Facilitate Consent of Legally Authorized Representatives to Clinical Trials

University Hospital Freiburg

NCT04608630 Phase 2

Bone Loss Prevention With Zoledronic Acid or Denosumab in Critically Ill Adults

Australia, New Zeala...

Australian and New Zealand Int...

NCT05014581 Phase 3

Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation

France, Ireland, Ita...

University of Turin, Italy

High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill

Region Stockholm

IL-6 and Hemogram-Derived Inflammatory Indices for Mortality Prediction in Postoperative ICU Patients

Turkey (Türkiye)

Ezgi Günaydın

Effects of Negative Pressure Ventilation Onto Hemodynamics and Right Ventricular Funktion in Patients After Implantation of a Left Ventricular Assist Device.

Karlsburg Hospital

NCT07220733 Phase 1, Phase 2

Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive Care Unit: a Pilot Trial

Exhaled Breath: A Novel Technique for Rapid Diagnosis of Respiratory Diseases and Infections

Oregon Health and Science Univ...

Using sEMG of the Diaphragm to Assess Readiness for Extubation

Cardiff and Vale University He...

Ultrasound Detection of Body Composition in Critical Care

Ain Shams University

Prospective Observational Study to Characterize Patients Treated at Internal Medicine Clinics

IRCCS San Raffaele

NCT06950294 EARLY_Phase 1

iNO300 Therapy in Critically Ill Patients With Pneumonia

Massachusetts General Hospital

Immune Modulation by Exosomes in COVID-19

University of Ulm

NCT06208332 Phase 2

The "What Is Important to Us" Communication Intervention Pilot Clinical Trial

Seattle Children's Hospital

Clinical Application of Listening to Music to Prevent Delirium in the Intensive Care Unit

HOSPITAL BRITANICO DE BUENOS A...

Establishing Normative Data for Pupillometer Assessments in Neuro-Intensive Care

University of Texas Southweste...

NCT07173855 Phase 4

Effect of Protocolized Magnesium Replacement on Mortality and Atrial Fibrillation in Critically Ill Patients

Scarborough General Hospital

Related Conditions

covid 19 (2) respiratory failure (2) circulatory shock (1) hemodynamic instability (1) hypotension (1) shock (1) extracorporeal membrane oxygenation complication (1) ards acute respiratory distress syndrome (1) intensive care medicine (1) cardiac arrest ca (1) pediatric intensive care unit (1) metabolomics (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology