Browse by Phase
Phase 3 Clinical Trials
Phase 3 trials compare a new drug or treatment against the current standard of care in a large population (300–3,000+ participants). Successful Phase 3 results are the basis for regulatory approval.
Total Trials
537
Recruiting Now
537
Top Conditions in Phase 3
Frequently Asked Questions — Phase 3 Trials
Why are Phase 3 trials the standard for drug approval?
Phase 3 trials compare a new treatment against the current standard of care in a large, randomized population of 300–3,000+ participants. This large-scale comparative evidence is what regulatory agencies—FDA, EMA—require to approve a new drug. A successful Phase 3 trial demonstrates that the new treatment is more effective, safer, or both compared to existing options in a statistically significant, reproducible way.
What is a placebo control in a Phase 3 trial?
Many Phase 3 trials use a placebo control—a group that receives an inactive substance—to isolate the true effect of the treatment. When an established standard of care exists, control-arm participants typically receive that treatment rather than a placebo, for ethical reasons. Blinded designs prevent participants and investigators from knowing who received which treatment, reducing bias in outcome assessment.
How do I find and join a Phase 3 clinical trial?
ClinicalMetric lists all Phase 3 trials registered on ClinicalTrials.gov. Each trial card shows recruitment status, enrollment target, sponsor, conditions studied, and site locations. To join a Phase 3 trial, review the eligibility criteria and contact the trial site directly—usually an academic medical center or hospital. Your physician can facilitate a referral to the appropriate study site.
Active Phase 3 Studies
NCT06602271 Phase 3
Recruiting
PF614 Analgesic Activity in Acute Postoperative Pain (PF614-301)
Condition
Postoperative Pain, Acute
Enrollment
320 pts
Location
United States
Sponsor
Ensysce Biosciences
NCT05677971 Phase 3
Recruiting
Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People ...
Condition
Alpha1-Antitrypsin Deficiency
Enrollment
160 pts
Location
United States, Australia, Austria
Sponsor
Takeda
NCT02735707 Phase 3
Recruiting
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acqu...
Condition
Respiratory Tract Diseases
Enrollment
20,000 pts
Location
United States, Australia, Belgium
Sponsor
UMC Utrecht
NCT05589181 Phase 3
Recruiting
High Dose Buprenorphine (BUP) Induction in the Emergency Department (ED)
Condition
Opioid Use Disorder
Enrollment
140 pts
Location
United States
Sponsor
Rutgers, The State University
NCT07571109 Phase 3
Recruiting
AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps...
Condition
Obesity
Enrollment
300 pts
Location
United States, Australia, China
Sponsor
Novo Nordisk A/S
NCT04087421 Phase 3
Recruiting
Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Lo...
Condition
Low Anterior Resection Syndrome
Enrollment
114 pts
Location
Denmark
Sponsor
University of Aarhus
NCT06431633 Phase 3
Recruiting
Study of Treatment With Sacituzumab and Zimberelimab for Patients With Lung Canc...
Condition
Lung Diseases
Enrollment
129 pts
Location
Spain
Sponsor
Fundación GECP
NCT07915609 Phase 3
Recruiting
A Study to Learn About Berobenatide Given Once Weekly in Adults With Knee Osteoa...
Condition
Obesity
Enrollment
756 pts
Location
United States
Sponsor
Pfizer
NCT05891093 Phase 3
Recruiting
Efficacy and Safety of Fluzoparib Combined With Adjuvant Endocrine Therapy for H...
Condition
Breast Cancer
Enrollment
766 pts
Location
China
Sponsor
Fudan University
NCT06691893 Phase 3
Recruiting
Evaluating the Efficacy of RELiZORB in Managing Exocrine Pancreatic Insufficienc...
Condition
Exocrine Pancreatic Insufficiency (EPI)
Enrollment
60 pts
Location
United States
Sponsor
Massachusetts General Hospital
NCT06736574 Phase 3
Recruiting
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With S...
Condition
Heart Failure
Enrollment
1,800 pts
Location
United States, Canada, China
Sponsor
Cytokinetics
NCT06467097 Phase 3
Recruiting
Systemic Treatment Alone Versus Systemic Treatment Plus Radiotherapy in Oligomet...
Condition
Kidney Neoplasm
Enrollment
88 pts
Location
South Korea
Sponsor
Samsung Medical Center
NCT06626035 Phase 3
Recruiting
Evaluation of Analgesia for Cardiac Elective Surgery in Children
Condition
Pediatric Cardiac Surgery
Enrollment
500 pts
Location
United States
Sponsor
Senthil Sadhasivam
NCT06861010 Phase 3
Recruiting
Evaluating the Safety and Efficacy of Ondansetron in the Prevention of Post Endo...
Condition
Pancreatic Diseases
Enrollment
44 pts
Location
Egypt
Sponsor
Tanta University
NCT07316296 Phase 3
Recruiting
Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing...
Condition
Parkinson's Disease (PD)
Enrollment
60 pts
Location
Netherlands
Sponsor
Radboud University Medical Cen
NCT07226076 Phase 3
Recruiting
Methadone in TKA for Post-op Pain and Opioid Reduction
Condition
Post Operative Pain
Enrollment
162 pts
Location
United States
Sponsor
Medical University of South Ca
NCT07606950 Phase 3
Recruiting
Phase III Study of HRS-5635 in Nucleos(t)Ide Analogue-suppressed HBeAg-negative ...
Condition
Nucleos(t)Ide Analogue-suppressed HBeAg-negative Patients With Chronic Hepatitis B
Enrollment
540 pts
Location
China
Sponsor
Fujian Shengdi Pharmaceutical
NCT04128189 Phase 3
Recruiting
Shingrix in Renal Transplant Recipients
Condition
Kidney Transplant Recipient Response to Shingrix Vaccine
Enrollment
132 pts
Location
United States
Sponsor
University of Colorado, Denver
NCT07872423 Phase 3
Recruiting
Phase III Trial of VDJ001 In Patients With Idiopathic Multicentric Castleman Dis...
Condition
Anti IL-6R
Enrollment
45 pts
Location
China
Sponsor
Beijing VDJBio Co., LTD.
NCT07251582 Phase 3
Recruiting
Effect of Infusion Timing on Pathologic Response to Neoadjuvant Immunotherapy in...
Condition
Resectable Stage II-III Non-Small Cell Lung Cancer (NSCLC)
Enrollment
186 pts
Location
China
Sponsor
Hunan Province Tumor Hospital
NCT04304625 Phase 3
Recruiting
TRAnexamic Acid for Preventing Blood Loss Following a Cesarean Delivery in Women...
Condition
Postpartum Hemorrhage
Enrollment
1,380 pts
Location
France
Sponsor
University Hospital, Bordeaux
NCT07245680 Phase 3
Recruiting
COMMODITIES Trial: Initial Dual Oral Therapy vs Monotherapy in PAH With Cardiova...
Condition
Pulmonary Arterial Hypertension (PAH)
Enrollment
186 pts
Location
France
Sponsor
Assistance Publique - Hôpitaux
NCT07505823 Phase 3
Recruiting
Phase Ⅲ Trial of Group ACYW135 Meningococcal Conjugate Vaccine in Children Aged ...
Condition
Epidemic Meningitis
Enrollment
1,040 pts
Location
China
Sponsor
Sinovac Biotech Co., Ltd
NCT06901297 Phase 3
Recruiting
The Efficacy and Safety of Raphamin in the Treatment of Acute Rhinosinusitis in ...
Condition
Rhinosinusitis
Enrollment
552 pts
Location
Russia
Sponsor
Materia Medica Holding
NCT07339423 Phase 3
Recruiting
AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps...
Condition
Obesity
Enrollment
1,150 pts
Location
United States, Argentina, Australia
Sponsor
Novo Nordisk A/S
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology