Clinical Trials / Browse by Phase / Phase 2

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Phase 2 Clinical Trials

Phase 2 trials study whether a drug works in people with a specific disease or condition. These studies enroll 100–300 participants and also continue to evaluate safety.

Total Trials

223

Recruiting Now

223

Top Conditions in Phase 2

Breast Cancer (5) Non-small Cell Lung Cancer (4) Acute Lymphoblastic Leukemia (4) Acute Myeloid Leukemia (3) Prostate Cancer (3) Chronic Lymphocytic Leukemia (3) Lymphoblastic Lymphoma (3) Multiple Myeloma (3) Ulcerative Colitis (3) Alzheimer Disease (2)

Frequently Asked Questions — Phase 2 Trials

What does a Phase 2 clinical trial evaluate?

Phase 2 trials assess whether a drug or treatment works in people with a specific disease or condition. Enrolling 100–300 participants, these studies collect preliminary efficacy data while continuing to monitor safety and identify the optimal dosing regimen. A successful Phase 2 outcome is required to advance to large-scale Phase 3 testing.

How long do Phase 2 trials typically take?

Phase 2 clinical trials typically run for 1–4 years, depending on the condition, endpoint complexity, and enrollment rate. Rare disease trials or those with long-term outcome measures may run longer. Many sponsors run Phase 2 studies at multiple sites simultaneously to accelerate recruitment.

Who can participate in a Phase 2 clinical trial?

Eligibility for Phase 2 trials is defined by specific inclusion and exclusion criteria. Participants are typically patients diagnosed with the condition under study and may or may not have received prior treatment. Age, disease stage, comorbidities, and laboratory values are common eligibility factors. Review each trial's criteria on ClinicalTrials.gov for specific requirements.

Active Phase 2 Studies

NCT07496918 Phase 2

Brain Effects of Gamma Frequency Sensory Stimulation (40Hz Light, Sound and Othe...

Cognitively Healthy People

Massachusetts Institute of Tec

NCT05593497 Phase 2

A Single-Arm Phase II Study of Neoadjuvant Intensified Androgen Deprivation (Leu...

High-Risk Prostate Cancer

VA Office of Research and Deve

NCT05004610 Phase 2

Hypertonic Lactate After Cardiac Arrest

Erasme University Hospital

NCT06510010 Phase 2

Perioperative Oxaliplatin With S-1 Combined H. Pylori Eradication in the Managem...

Chemotherapy Effect

Sixth Affiliated Hospital, Sun

NCT06734182 Phase 2

Neoadjuvant Envafolimab Plus Disitamab Vedotin and Carboplatin in Resectable HER...

Non-small Cell Lung Cancer

Guangdong Provincial People's

NCT05617859 Phase 2

Lenvatinib for Advanced Bone and Soft Tissue Sarcoma

Henan Cancer Hospital

NCT07464366 Phase 2

The Safety and Efficacy of MRG003 With or Without Putrelimab in Recurrent or Met...

Salivary Gland Carcinomas

NCT05124951 Phase 2

The Efficacy of WVI in Patients With Localized Basal Ganglia Intracranial Germ C...

Intracranial Germ Cell CNS Tumor, Childhood

Beijing Tiantan Hospital

NCT06611813 Phase 2

Neoadjuvant Chemotherapy in Combination With Toripalimab for HR+/HER2- Breast Ca...

HR+/HER2- Breast Cancer

First Affiliated Hospital of Z

NCT07070466 Phase 2

Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA

Stomach Cancer Stage IV

Massachusetts General Hospital

NCT06993610 Phase 2

Tibulizumab Skin Healing and Inflammation Evaluation for Lasting Defense

Hidradenitis Suppurativa (HS)

United States, Canada, Germany

NCT06121505 Phase 2

Phase II Trial: Low-Dose Radiation + SBRT + Sintilimab + Chemotherapy vs. Sintil...

Lung Squamous Cell Carcinoma

Sichuan University

NCT07548710 Phase 2

Study of SA+X in the Treatment of Newly Diagnosed AML

Acute Myeloid Leukemia

Ruijin Hospital

NCT07292883 Phase 2

Accelerated dTMS Smoking Cessation

Tobacco Use Disorder

Waypoint Centre for Mental Hea

NCT07018622 Phase 2

Protecting the Kidney's Proximal Tubules From Platinum-Based Chemotherapy Toxici...

Instituto Nacional de Ciencias

NCT05965856 Phase 2

A Study of SI-B003 and BL-B01D1+SI-B003 in Patients With Locally Advanced or Met...

Urothelial Carcinoma

Sichuan Baili Pharmaceutical C

NCT07047690 Phase 2

A Study of Nemolizumab for the Treatment of Adults With Systemic Sclerosis

Systemic Sclerosis

United States, Switzerland

NCT06632613 Phase 2

Efficacy and Safety of ENN0403 in Patients At High Risk for Acute Kidney Injury ...

Cardiac Surgery Associated - Acute Kidney Injury

NCT07027124 Phase 2

Neoadjuvant ADT + Darolutamide With Pembrolizumab, Followed by Adjuvant Pembroli...

Prostate Cancer

Icahn School of Medicine at Mo

NCT05932680 Phase 2

Limited-duration Teclistamab

Myeloma Multiple

Abramson Cancer Center at Penn

NCT07023588 Phase 2

Study on Optimizing the Treatment of Patients With Acute Myeloid Leukemia Based ...

Acute Myeloid Leukemia (AML)

NCT07475403 Phase 2

Urinary Tumor DNA-Guided Systemic Immunotherapy for Unresectable Very-High-Risk ...

Tianjin Medical University Sec

NCT02939573 Phase 2

A Randomized Multicenter Study for Isolated Skin Vasculitis

Primary Cutaneous Vasculitis

United States, Canada, Japan

University of Pennsylvania

NCT07153796 Phase 2

A Phase 2 Study to Assess the Safety and Efficacy of Subcutaneous Blinatumomab i...

B-cell Acute Lymphoblastic Leukemia

M.D. Anderson Cancer Center

NCT04452461 Phase 2

Pancreatic Adenocarcinoma Neoadjuvant Chemotherapy Before Surgery

Pancreatic Adenocarcinoma

Hamilton Health Sciences Corpo

Page 1 of 9 — 223 trials total

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology