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low back pain

Total Trials
15
Recruiting Now
15
Trial Phases
Various

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain β€” each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — low back pain Clinical Trials

How many clinical trials are currently recruiting for low back pain?
ClinicalMetric currently tracks 15 actively recruiting clinical trials for low back pain, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 15. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for low back pain?
low back pain research spans multiple clinical trial phases. Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a low back pain clinical trial?
Eligibility criteria for low back pain trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Top Sponsors
Riphah International University 2 trials
Hasselt University 1 trial
Pamukkale University 1 trial
Gali Dar 1 trial
University Hospital, Angers 1 trial

Recruiting Clinical Trials

NCT06785909
Recruiting
Proprioceptive, Fear-related and Inflammatory Factors in the Persistence of Pregnancy-related Lumbopelvic Pain.
Enrollment
211 pts
Location
Belgium
Sponsor
Hasselt University
View Trial →
NCT06686147
Recruiting
AI-Assisted Analysis of Range of Motion in Patients With Low Back Pain
Enrollment
100 pts
Location
Turkey (Türkiye)
Sponsor
Pamukkale University
View Trial →
NCT06894355
Recruiting
Group Hydrotherapy Treatment for Athletes With Lower Back Pain
Enrollment
50 pts
Location
Israel
Sponsor
Gali Dar
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NCT04826757
Recruiting
Effectiveness of Coordinated Care to Reduce the Prolonged Disability Risk Among Patients Suffering From Low Back Pain in Primary Care
Enrollment
500 pts
Location
France
Sponsor
University Hospital, Angers
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NCT07463729
Recruiting
Evaluation of Stabilization Training With Biofeedback in Lumbosacral Spine Pain Syndrome
Enrollment
110 pts
Location
Poland
Sponsor
University of Rzeszow
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NCT06818175
Recruiting
Physical Exam, Static & Dynamic Ultrasound Assessment, & Treatment of Thoracolumbar Fascia (TLF) Mediated Low Back Pain
Enrollment
200 pts
Location
United States
Sponsor
Edward Via Virginia College of...
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NCT07026058
Recruiting
Sound Sine Wave And Standard Physiotherapy In Mechanical Low Back Pain
Enrollment
40 pts
Location
Pakistan
Sponsor
Riphah International Universit...
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NCT06549660
Recruiting
PBMT in Providing Temporary Relief of Low Back Pain of Musculoskeletal Origin
Enrollment
68 pts
Location
Brazil
Sponsor
University of Nove de Julho
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NCT07298109
Recruiting
Diaphragmatic Release for Low Back Pain
Enrollment
42 pts
Location
Turkey (Türkiye)
Sponsor
Karabuk University
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NCT06985849
Recruiting
Effects of Feldenkrais and Otago Exercise Protocols for Mechanical Low Back Pain
Enrollment
36 pts
Location
Pakistan
Sponsor
Riphah International Universit...
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NCT06590116
Recruiting
Perspectives on Spinal Manipulative Therapy for Low Back Pain
Enrollment
90 pts
Location
United States
Sponsor
University of Florida
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NCT04164225
Recruiting
Feasibility of Identifying Brain Mechanisms of Qigong and Behavioral Outcomes After Qigong Practice in People With Chronic Low Back Pain
Enrollment
60 pts
Location
United States
Sponsor
University of Minnesota
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NCT07327554
Recruiting
Assessment of the Evolution of Lumbar Spine Movement Fluidity Using Xsens Inertial Sensors in Subjects With Chronic Low Back Pain Before and After Rehabilitation
Enrollment
25 pts
Location
France
Sponsor
University Hospital, Montpelli...
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NCT05231265
Recruiting
Effect of Lumbar Surgery on Complexity During a Walking Task in Chronic Low Back Pain
Enrollment
32 pts
Location
France
Sponsor
Centre Hospitalier Universitai...
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NCT07433634
Recruiting
Time to BBVNA Relief
Enrollment
200 pts
Location
United States
Sponsor
Yale University
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Related Conditions

chronic low back pain (2) lumbopelvic pain (1) pelvic girdle pain (1) acute low back pain (1) diaphragm relaxation (1) vertebrogenic pain syndrome (1) basivertebral nerve ablation (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology