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low back pain

Total Trials

18

Recruiting Now

18

Trial Phases

Various

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain β€” each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — low back pain Clinical Trials

How many clinical trials are currently recruiting for low back pain?

ClinicalMetric currently tracks 18 actively recruiting clinical trials for low back pain, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 18. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for low back pain?

low back pain research spans multiple clinical trial phases. Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a low back pain clinical trial?

Eligibility criteria for low back pain trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Top Sponsors

Riphah International University 2 trials

Cairo University 2 trials

Aveiro University 1 trial

Federal University of Minas Gerais 1 trial

Weill Medical College of Cornell University 1 trial

Recruiting Clinical Trials

Potential of Virtual Reality in Primary Chronic Low Back Pain

Aveiro University

YOga for Patients with Chronic BACK Pain and Poor PROgnosis

Federal University of Minas Ge...

Biologic Injection For Adults With Lumbar Disc Herniation

Weill Medical College of Corne...

MyBack - A Behavior Change Informed Exercise Program to Prevent Low Back Pain Recurrences

Instituto Politécnico de Setúb...

Office Program Effects on Pain, Posture, Muscle Physiology, Stress, Ergonomics, and Quality of Life in LBP Workers

Suci Wahyu Ismiyasa

Motivating Core-muscle Exercises With Wearable Sensors, Haptics and Interactive Gaming

Imperial College London

Effects of Sedante Neo Therapy on Pain, Range of Motion and Quality of Life in Patients With Non Specific Low Back Pain.

Riphah International Universit...

The Role of Proprioceptive Deficits, Psychosocial Factors and Inflammation in Pregnancy-related Pelvic Girdle Pain

Hasselt University

Three CT Signs of Nerve-root Suffering in Low-back Sciatica: a Study of Their Frequency in Patients Referred for CT-guided Nerve-root Infiltration.

Centre Hospitalier Universitai...

Placebo-Induced Hypoalgesia During Transcutaneous Electrical Nerve Stimulation Application in Low Back Pain

Cairo University

Pilates Exercises on Nonspecific Low Back Pain in Postnatal Women

Kafrelsheikh University

Online Versus Physically Supervised Pilates Exercise Program in Non-specific Low Back Pain

Riphah International Universit...

Comparative Effects Of Post Isometric Relaxation Versus Active Isolated Stretch In Patients With Piriformis Syndrome

Foundation University Islamaba...

AuriculoTherapy NeuroImaging

Effectiveness of Pilates on Postural Correction, Core Strength and Flexibility in Younger Individuals With Non-specific Low Backache

University of Health Sciences ...

Development and Validation of the Italian Version of the Waddell Chronic Disability Index for People With Low Back Pain

Istituti Clinici Scientifici M...

Effect of Manual Therapy on Low Back Pain in Osteopenic Postmenopausal Women

Cairo University

Ischemic Preconditioning in Osteoarthritis and Back Pain

University of Illinois at Chic...

Related Conditions

chronic low back pain (2) back pain lower back chronic (2) degenerative disc disease lumbar (2) non specific low back pain (2) back pain (1) degenerative disc disease (1) ddd (1) lumbar disc herniation (1) disc herniation lumbar (1) bone marrow aspirate concentrate (1) intervertebral disc displacement (1) chronic low back pain clbp (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology