NCT07690449 Three CT Signs of Nerve-root Suffering in Low-back Sciatica: a Study of Their Frequency in Patients Referred for CT-guided Nerve-root Infiltration.
| NCT ID | NCT07690449 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Centre Hospitalier Universitaire de Nice |
| Condition | Sciatica |
| Study Type | OBSERVATIONAL |
| Enrollment | 400 participants |
| Start Date | 2024-01-30 |
| Primary Completion | 2026-03-04 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 400 participants in total. It began in 2024-01-30 with a primary completion date of 2026-03-04.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Retrospective, observational, single-centre study conducted at Nice University Hospital (Pasteur 2), Department of Diagnostic and Interventional Radiology. Objective: to assess the prevalence of three CT signs sought next to the clinically suspected nerve root in patients with low-back sciatica referred for CT-guided foraminal/peri-radicular infiltration: (1) nerve-root size asymmetry/hypertrophy, (2) peri-radicular infiltration, and (3) spontaneous root hyperdensity. Hypothesis: these signs are associated with the suffering nerve root responsible for the clinical presentation. Pre-infiltration planning CT scans (period 30 Jan 2024 - 11 Jul 2024) are reviewed by the operating radiologists (4th-, 5th- and 6th-year residents). Target enrollment: 400 patients. Data analysed to date: 104 patients / 105 infiltrations. Preliminary prevalence: root asymmetry/hypertrophy 45.5%; peri-radicular infiltration 50.5%; spontaneous hyperdensity 23.8%; at least 2 of 3 signs 38.6%; all 3 signs 16.8%. Mean age 65 years (range 25-93); approximately 62 women / 42 men; predominant levels L4-L5 and L5-S1.
Eligibility Criteria
Inclusion Criteria: * Adult (\>= 18 years) * Low-back sciatica / radicular pain with a systematized distribution * Referred for CT-guided foraminal or peri-radicular infiltration at Pasteur 2 Hospital (Nice) between 30 Jan 2024 and 11 Jul 2024. * Available and interpretable pre-infiltration planning CT Exclusion Criteria: * Planning CT missing or not interpretable * Missing data on the three studied signs * Radicular pain of tumoral, infectious or recent traumatic origin * Spinal history precluding analysis of the studied root
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07690449 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Sciatica. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07690449 currently recruiting?
Yes, NCT07690449 is actively recruiting participants. Contact the research team at kevindesalos@gmail.com for enrollment information.
Where is the NCT07690449 trial being conducted?
This trial is being conducted at Nice, France.
Who is sponsoring the NCT07690449 clinical trial?
NCT07690449 is sponsored by Centre Hospitalier Universitaire de Nice. The trial plans to enroll 400 participants.