Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium
Trial Parameters
Brief Summary
The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. The main questions it aims to answer are: 1. To define sleep/circadian biomarkers of delirium (sleep duration, regularity, stability and timing of rhythm) in a prospective observational study. 2. To determine if plasma Alzheimer's disease (AD) pathology/inflammatory burden interacts with or moderates the relationship between a sleep/circadian biomarker and post-operative delirium (POD) risk. 3. To determine whether sleep/circadian regulation interacts with the genetic risk of AD to influence POD/cognitive decline. Participants will be asked to: 1. Donate several blood samples both intraoperatively and postoperatively 2. Complete baseline and postoperative neurocognitive assessments 3. Wear an actigraphy data collection watch for the two weeks prior to their surgery
Eligibility Criteria
Inclusion Criteria: * Age \>= 70 years old * Scheduled to undergo major orthopedic surgery * Expected postoperative recovery of more than 24 hours as an inpatient Exclusion Criteria: * Cognitive impairment leading to inability to consent * Patients with limited mobility or inability to wear an actigraphy watch * Patients with infection at the site of actigraphy watch, allergies to materials of watch * Patients with \> two days in the ICU during the month prior to surgery * Renal or liver failure * Severe neurocognitive damage or history of psychiatric illness * Blindness or deafness * Patients who are non-English speaking