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cognitive decline

Total Trials
12
Recruiting Now
12
Trial Phases
Phase 2

ClinicalMetric tracks all active clinical trials for cognitive decline sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — cognitive decline Clinical Trials

How many clinical trials are currently recruiting for cognitive decline?
ClinicalMetric currently tracks 12 actively recruiting clinical trials for cognitive decline, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 12. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for cognitive decline?
cognitive decline research spans Phase 2 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a cognitive decline clinical trial?
Eligibility criteria for cognitive decline trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 2
2
Top Sponsors
University of Milano Bicocca 1 trial
Alzheimer's Light LLC 1 trial
The University of Tennessee, Knoxville 1 trial
Dingqun Bai 1 trial
Natalie Denburg 1 trial

Recruiting Clinical Trials

NCT07804498 Phase 2
Recruiting
CITADEL: Effectiveness of CITicoline in Preventing Cognitive Decline After DELirium
Enrollment
122 pts
Location
Italy
Sponsor
University of Milano Bicocca
View Trial →
NCT03657745
Recruiting
Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
Enrollment
2,000 pts
Location
United States
Sponsor
Alzheimer's Light LLC
View Trial →
NCT07207993
Recruiting
Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline
Enrollment
64 pts
Location
United States
Sponsor
The University of Tennessee, K...
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NCT06703320
Recruiting
Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task in Stroke Patients: an FNIRS Study
Enrollment
60 pts
Location
China
Sponsor
Dingqun Bai
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NCT03954899
Recruiting
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
Enrollment
230 pts
Location
United States
Sponsor
Natalie Denburg
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NCT05922137
Recruiting
Oriental Intervention for Enhanced Neurocognitive Health (ORIENT) Diet in Patients With Intracranial / Carotid Stenosis
Enrollment
120 pts
Location
China
Sponsor
Second Affiliated Hospital, Zh...
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NCT06727773 Phase 2
Recruiting
Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer
Enrollment
90 pts
Location
United States
Sponsor
UNC Lineberger Comprehensive C...
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NCT05106036
Recruiting
Preventing Cognitive Decline by Reducing BP Target Trial
Enrollment
4,000 pts
Location
United States
Sponsor
University of Texas Southweste...
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NCT06507254
Recruiting
Polyphenols and Cognitive Decline
Enrollment
300 pts
Location
United States
Sponsor
University of California, Los ...
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NCT05088187
Recruiting
Cognition and QoL After Thyroid Surgery
Enrollment
320 pts
Location
Sweden
Sponsor
Karolinska University Hospital
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NCT07242495
Recruiting
Additional Effects of Immersive vr 360 Degree Videos With Aerobic Exercises on Cognitive Functions in Elderly With Mild Cognitive Impairment
Enrollment
34 pts
Location
Pakistan
Sponsor
Foundation University Islamaba...
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NCT06730711
Recruiting
Association Between Blood Pressure and Risk of PSCI
Enrollment
600 pts
Location
China
Sponsor
First Affiliated Hospital of C...
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Related Conditions

mild cognitive impairment (2) dementia (2) stroke (2) cognitive change (2) blood pressure (2) delirium (1) alzheimer disease (1) cognition disorders in old age (1) cognitive deterioration (1) older adults with cognitive decline (1) older adults (1) ai based fitness (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: September 2026  ·  Data Methodology