NCT07048522 Perioperative Intravenous Nimodipine Trial
| NCT ID | NCT07048522 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Ioannina |
| Condition | Colectomy |
| Study Type | INTERVENTIONAL |
| Enrollment | 40 participants |
| Start Date | 2025-05-19 |
| Primary Completion | 2026-05-19 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 40 participants in total. It began in 2025-05-19 with a primary completion date of 2026-05-19.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The role of perioperative IV administration of nimodipine, an L-type calcium channel antagonist which is capable of crossing the blood-brain barrier, on peri-operative opioid and anesthetics requirements, pain intensity, opioid-related side effects and early postoperative bowel mobility in patients undergoing surgical treatment for bowel cancer with open radical colectomy remains scarcely explored. A prospective double-blind, randomized controlled trial investigating the effect of perioperative IV administration of nimodipine in patients undergoing open colectomy for cancer treatment is therefore conducted.
Eligibility Criteria
Inclusion Criteria: * Patients scheduled for open surgical treatment of bowel cancer at the General Hospital of Patra Exclusion Criteria: * Age \< 18 years, \> 75 years * American Society of Anesthesiologists (ASA) physical status \> III * Allergy to nimodipine * Inability to provide informed consent * Known severe renal insufficiency * Known severe bradyarrhythmia * Daily opioid consumption the last 7 days before surgery * Pain intensity assessed using the Numerical Rating Scale (NRS; 0-10), with scores greater than 5 reported on more than half of the days during the past month.
Contact & Investigator
Petros Tzimas, MD, PhD
PRINCIPAL INVESTIGATOR
University of Ioannina, Greece
Frequently Asked Questions
Who can join the NCT07048522 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Colectomy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07048522 currently recruiting?
Yes, NCT07048522 is actively recruiting participants. Contact the research team at marilizafilou@gmail.com for enrollment information.
Where is the NCT07048522 trial being conducted?
This trial is being conducted at Pátrai, Greece.
Who is sponsoring the NCT07048522 clinical trial?
NCT07048522 is sponsored by University of Ioannina. The principal investigator is Petros Tzimas, MD, PhD at University of Ioannina, Greece. The trial plans to enroll 40 participants.