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Medical Condition

pain

Total Trials

48

Recruiting Now

48

Trial Phases

EARLY_Phase 1, Phase 2, Phase 4

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain β€” each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — pain Clinical Trials

How many clinical trials are currently recruiting for pain?

ClinicalMetric currently tracks 48 actively recruiting clinical trials for pain, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 48. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for pain?

pain research spans Phase 1 (2 trials), Phase 2 (2 trials), Phase 4 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a pain clinical trial?

Eligibility criteria for pain trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

2

Phase 2

2

Phase 4

3

Top Sponsors

Beijing Tiantan Hospital 3 trials

Riphah International University 2 trials

Centre Hospitalier Emile Roux 1 trial

University of Catanzaro 1 trial

University of Alabama at Birmingham 1 trial

Recruiting Clinical Trials

Evolution of Insomnia During the First Year in Patients Newly Diagnosed With Cancer

Centre Hospitalier Emile Roux

Diamagnetic Therapy in Pain and Inflammation

University of Catanzaro

State of Hormones Impact Nociceptive Expression

University of Alabama at Birmi...

Validity and Reliability Study of the Pain Indicator Behavior Scale-Brain Damage (ESCID-DC)

Candelas Lopez Lopez

Registry of Outcomes of Dezawa MuseCells®

United States, Mexic...

MuseCell Innovations Pte LTD

Multimodal Analgesia Utilization and Acute Postoperative Pain After Major Surgery at Mulago National Referral Hospital

Makerere University

Effect of Targeted Mobilization Program

Turkey (Türkiye)

Nigde Omer Halisdemir Universi...

The Efficacy and Safety of Pregabalin Combined With Toludesvenlafaxine in Patients With Fibromyalgia

Beijing Tiantan Hospital

The Analgesic Efficacy and Safety of Flurbiprofen Patch in Patients With Herpes Zoster

Beijing Tiantan Hospital

Effects of Exercise Therapy and Soft Brace on Knee Osteoarthritis

University College of Northern...

NCT06810336 EARLY_Phase 1

Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery

University of Virginia

Acute Pain Oscillation in Electroencephalographic Monitoring Under General Anaesthesia

Hospital General Universitario...

Transdiagnostic Cognitive Biomarkers

University of Minnesota

Feasibility Study of a Guided Imagery Therapy Mobile Application for Functional Abdominal Pain Disorders in Children

Baylor College of Medicine

NCT05269628 Phase 2

Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype

Tiffany J. Braley, MD, MS

Feasibility of Choose to Move Replacement Ready

University of British Columbia

Additional Effects of Neural Mobilization on Pain, Balance and Quality of Life in Diabetic Neuropathy

Foundation University Islamaba...

The Effect of a Stress Ball During Oral Care Procedures

Turkey (Türkiye)

Yuzuncu Yil University

NCT06393608 Phase 2

Epsom Salt Compresses to Relieve Perineal for Postpartum Care: a Clinical Trial

Pain With Dementia

Duke University

Efficacy of Physical Therapy Treatment in Endometriosis and Its Relationship to Adherence Rates.

University of Seville

Effects of Extracorporeal Shockwave Therapy Versus Dry Needling on Jumpers Knee

Riphah International Universit...

Midpoint Transverse Process to Pleura (MTP) Block vs Erector Spinae Plane (ESP) Block for Acute Herpes Zoster (HZ) Pain

Tanta University

Training in Evidence-based Treatments in Psycho-Oncology

Massachusetts General Hospital

Pre-emptive Scalp Infiltration With Low-dose Flurbiprofen and Ropivacaine for Postoperative Analgesia After Craniotomy

Beijing Tiantan Hospital

Effects of Sedante Neo Therapy on Pain, Range of Motion and Quality of Life in Patients With Non Specific Low Back Pain.

Riphah International Universit...

Hip Arthroscopy Postoperative Opioid Demands

Rush University Medical Center

Pain Intervention With Needling: Pilot Of Integrated Neuromodulation Techniques

The University of Texas Medica...

NCT05988710 Phase 4

Low-dose Buccal Buprenorphine: Relative Abuse Potential and Analgesia

Vanderbilt University Medical ...

Sociocultural & Biobehavioral Influences on Pain Expression and Assessment

National Center for Complement...

Pain After Cardiac Arrest and Resuscitation (PAINCARE)

Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG)

University of Maryland, Baltim...

Trauma-adapted Yoga in Child & Adolescent Psychiatry.

University West, Sweden

Pivotal Study on the NOVABLOC System for Patients Undergoing Primary Total Knee Arthroplasty

Synaptrix, Inc.

The Effect of a Kaleidoscope and Cartoons for Dental Treatment in Children

Turkey (Türkiye)

Dicle University

Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain

The University of Texas Health...

NCT04102566 Phase 4

Optimizing Pain Control in Transurethral Resection of the Prostate

Benaroya Research Institute

NCT07290205 EARLY_Phase 1

Remimazolam NeuroImaging

NCT07538570 Phase 4

Evaluation of Pain Treatment After Total Knee Arthroplasty

Vertex Pharmaceuticals Incorpo...

Pain in Pediatric Dentistry - a Grounded Theory Study on the Experiences of Dental Professionals and Students

Malmö University

How Digital Media Affects Kids' Healthcare Experiences and Outcomes

British Columbia Children's Ho...

Effectiveness of Musicotherapy in Reducing Pain Induced by Leg Ulcer Care

University Hospital Center of ...

Perioperative Virtual Reality Intervention for Pain and Anxiety During Vasectomies

University of Manitoba

Pervasive Sensing and AI in Intelligent ICU

University of Florida

Effect of Dexamethasone on Plasma Levels of Bupivacaine and Dexamethasone After a Single-injection Interscalene Nerve Block.

Pontificia Universidad Catolic...

Somatosensory Phenotyping of ADPKD

Universitaire Ziekenhuizen KU ...

Effect of Erector Spinae (ESP) Block on Opioid Reduction and Enhanced Recovery After Posterior Cervical Spine Surgery

University Health Network, Tor...

Pain in Aging Former Athletes, Master's Athletes, and Nonathletes

Marquette University

Related Conditions

quality of life (6) virtual reality (3) insomnia (2) postoperative (2) endometriosis related pain (2) pain management (2) anxiety (2) cancer (1) depression anxiety disorder (1) inflammation (1) gender identity (1) brain injuries (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology