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pain

Total Trials
9
Recruiting Now
9
Trial Phases
Phase 3

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain — each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — pain Clinical Trials

How many clinical trials are currently recruiting for pain?
ClinicalMetric currently tracks 9 actively recruiting clinical trials for pain, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 9. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for pain?
pain research spans Phase 3 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a pain clinical trial?
Eligibility criteria for pain trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 3
2
Top Sponsors
Selcuk University 1 trial
National Center for Complementary and Integrative Health (NCCIH) 1 trial
Riphah International University 1 trial
Universidad Rey Juan Carlos 1 trial
Major Extremity Trauma Research Consortium 1 trial

Recruiting Clinical Trials

NCT07268027
Recruiting

Constructivist Prenatal Education Effects

Enrollment
126 pts
Location
Turkey (Türkiye)
Sponsor
Selcuk University
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NCT02446262
Recruiting

Neural and Psychological Mechanisms of Pain Perception

Enrollment
500 pts
Location
United States
Sponsor
National Center for Complement...
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NCT07579039
Recruiting

Combined Effect of Prenatal Stretching and Kinesiotaping in Pregnant Women With Low Back Pain

Enrollment
34 pts
Location
Pakistan
Sponsor
Riphah International Universit...
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NCT06638515
Recruiting

Effects of Walking Apnea At Low Lung Volume on Hypoalgesia

Enrollment
60 pts
Location
Spain
Sponsor
Universidad Rey Juan Carlos
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NCT07006675 Phase 3
Recruiting

Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial

Enrollment
1,000 pts
Location
United States, Canad...
Sponsor
Major Extremity Trauma Researc...
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NCT07378059
Recruiting

The Analgesic Efficacy and Safety of Loxoprofen Sodium Patch in Patients With Herpes Zoster

Enrollment
750 pts
Location
China
Sponsor
Beijing Tiantan Hospital
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NCT05981261
Recruiting

Experimental Pain in Parkinsons

Enrollment
63 pts
Location
Denmark
Sponsor
University of Aarhus
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NCT04189965
Recruiting

Traumatic Long-term Memory of Pain in Humans

Enrollment
180 pts
Location
France
Sponsor
Hospices Civils de Lyon
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NCT07226700 Phase 3
Recruiting

Suzetrigine in Total Hip Arthroplasty

Enrollment
210 pts
Location
United States
Sponsor
Hospital for Special Surgery, ...
View Trial →
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology