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pain

Total Trials

24

Recruiting Now

24

Trial Phases

Phase 3, Phase 4, EARLY_Phase 1

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain β€” each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — pain Clinical Trials

How many clinical trials are currently recruiting for pain?

ClinicalMetric currently tracks 24 actively recruiting clinical trials for pain, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 24. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for pain?

pain research spans Phase 1 (1 trial), Phase 3 (3 trials), Phase 4 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a pain clinical trial?

Eligibility criteria for pain trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

1

Phase 3

3

Phase 4

2

Top Sponsors

Bandırma Onyedi Eylül University 1 trial

Università degli Studi del Piemonte Orientale Amedeo Avogadro 1 trial

C K S Teja Institute Of Dental Sciences & Research 1 trial

Riphah International University 1 trial

University of Manitoba 1 trial

Recruiting Clinical Trials

Investigation of the Relationship Between Core Stability and Reaction Time, Hand-Eye Coordination, Pain, and Functional Status in Individuals With Rotator Cuff Lesions

Turkey (Türkiye)

Bandırma Onyedi Eylül Universi...

Hypnotic Communication in Cardiology: A Randomized Controlled Trial

Università degli Studi del Pie...

Comparative Evaluation of SMART Hall Technique Vs. Conventional SS Crown in Primary Molars: a Randomized Clinical Trial

C K S Teja Institute Of Dental...

Effects of Sedante Neo Therapy on Pain, Range of Motion and Quality of Life in Patients With Non Specific Low Back Pain.

Riphah International Universit...

Perioperative Virtual Reality Intervention for Pain and Anxiety During Vasectomies

University of Manitoba

NCT06387290 Phase 3

Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits

University of Utah

Physiotherapist-Supervised Online Exercise in Remote White-Collar Workers

Turkey (Türkiye)

Marmara University

NCT07224711 Phase 4

The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery

Vanderbilt University Medical ...

NCT03823534 Phase 3

Post-Op Pain Control for Prophylactic Intramedullary Nailing.

St. Louis University

Is Low-load Resistance Training With Blood Flow Restriction Feasible During Rehabilitation of Military Personnel With Lower Limb Injuries? Phase One RCT.

Defence Medical Rehabilitation...

The Efficacy and Safety of Pregabalin Combined With Toludesvenlafaxine in Patients With Fibromyalgia

Beijing Tiantan Hospital

The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology.

University Hospital, Clermont-...

Unipolar Versus Bipolar Radiofrequency Ablation in Knee Osteoarthritis Pain

Tanta University

Peloid Therapy in Temporomandibular Joint Dysfunction

Turkey (Türkiye)

Uşak University

UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture

Sunnybrook Health Sciences Cen...

NCT06810336 EARLY_Phase 1

Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery

University of Virginia

NCT06962306 Phase 4

Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery

Duke University

Anesthetics and Analgesics in Children

United States, Canad...

Chi Dang Hornik

Oklahoma Study of Native American Pain Risk IV: Smoking Cessation and Pain

University of Oklahoma

Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI

Medical University of South Ca...

The Effect of Standardizing Procedures for SC Injections of LMWH on Patients With CVD

The Hong Kong Polytechnic Univ...

NCT06032559 Phase 3

Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment

Rutgers, The State University ...

Effectiveness of Multisensoral Nature-based Intervention in Hospitalized Children During Venous Blood Sampling

University of Oulu

Is Repetitive Transcranial Magnetic Stimulation Effective in Reducing Endometriosis-associated Pain

University of Ottawa

Related Conditions

anxiety (3) opioid use (2) endometriosis (2) postoperative care (2) core stability (1) core stabilization (1) reaction time (1) function (1) psychological distress (1) caries dental (1) plaque dental (1) gingival bleeding (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology