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pain

Total Trials

49

Recruiting Now

49

Trial Phases

Phase 3, Phase 2, Phase 1

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain β€” each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — pain Clinical Trials

How many clinical trials are currently recruiting for pain?

ClinicalMetric currently tracks 49 actively recruiting clinical trials for pain, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 49. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for pain?

pain research spans Phase 1 (2 trials), Phase 2 (3 trials), Phase 3 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a pain clinical trial?

Eligibility criteria for pain trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

2

Phase 2

3

Phase 3

2

Top Sponsors

Yale University 3 trials

Ankara Etlik City Hospital 1 trial

Vancouver Island Health Authority 1 trial

Kirsehir Ahi Evran Universitesi 1 trial

Cairo University 1 trial

Recruiting Clinical Trials

Preoperative Maxillary Nerve Block and Remifentanil Use in Septorhinoplasty

Turkey (Türkiye)

Ankara Etlik City Hospital

Cryoneurolysis for Knee and Shoulder Pain in an Inpatient Setting

Vancouver Island Health Author...

Suprascapular Nerve Block in Patients Rehabilitated After Arthroscopic Rotator Cuff Repair

Turkey (Türkiye)

Kirsehir Ahi Evran Universites...

Acupuncture Versus Transcutaneous Electrical Nerve Stimulation on Pain Post Upper Abdominal Surgeries

Cairo University

Augmented Reality For MRI-Guided Interventions

Children's National Research I...

Virtual Reality in Elective Caesarean Births Study (VREC)

Royal United Hospitals Bath NH...

NCT06032559 Phase 3

Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment

Rutgers, The State University ...

Pain With Dementia

Duke University

NCT06393608 Phase 2

Epsom Salt Compresses to Relieve Perineal for Postpartum Care: a Clinical Trial

MucoLock™ for Treatment of Stomatitis

Baptist Health South Florida

NCT06498713 Phase 1

Patient Controlled Administration of Liquid Acetaminophen

Yale University

Trauma-adapted Yoga in Child & Adolescent Psychiatry.

University West, Sweden

The Effectiveness of BETY in Knee Osteoarthritis With Intra-Articular Injections

Turkey (Türkiye)

Hacettepe University

NCT07006675 Phase 3

Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial

United States, Canad...

Major Extremity Trauma Researc...

Comparative Evaluation of SMART Hall Technique Vs. Conventional SS Crown in Primary Molars: a Randomized Clinical Trial

C K S Teja Institute Of Dental...

Bio-significance of LPC16:0 in Fibromyalgia

Kaohsiung Medical University C...

M2VA Pain Care Pathway

Yale University

Combined Effects of Virtual Reality and Motor Imagery in Patients With Non-specific Neck Pain

Riphah International Universit...

Auricular Acupuncture in Patients With Advanced Cancer: a Randomized Clinical Trial.

University Hospital Tuebingen

A Combined Treatment of Manual Therapy and Nervous Vagus Stimulation in Patients With Myogenic Temporomandibular Disorders

University of Alcala

Is Repetitive Transcranial Magnetic Stimulation Effective in Reducing Endometriosis-associated Pain

University of Ottawa

A Handheld Tool for Active Distraction of Children and Adolescents During Painful Procedures

Haukeland University Hospital

Effect of Photobiomodulation to Reduce Post-operative Pain After Endodontic Surgery

University of Nove de Julho

Effect of Voiding Position (Standing in the Shower vs. Sitting) on Post-Void Residual Urine Volume (PVR) After Removal of Urinary Catheter in Women Following Benign Vaginal Gynecologic Surgery

Assuta Ashdod Hospital

Geriatric Trauma Care Program for Living Alone Older Adults With Injuries

Kaohsiung Medical University

The Effect of Watching Video and Blowing Paper Pinwheels in Children

Taichung Veterans General Hosp...

Effects of Hot Sacral Massage and Shower Application With Partner Support on Labor

Turkey (Türkiye)

Istanbul University - Cerrahpa...

Opioid Misuse in Patients with Cancer

Rigshospitalet, Denmark

Effect of a Novel Topical Composition on the Incidence of Severe Oral Mucositis in Head & Neck Cancer Radiated Patients and Quality of Life Assessed by PROMs.

Mucosa Innovations, S.L.

Pain Outcomes Associated With Exogenous Hormone Therapy in Adults

University of Kansas Medical C...

Stress and Pain in People Living With HIV

Yale University

RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain

United States, Argen...

Boston Scientific Corporation

The Pain Reduction Using Immersive Virtual Reality During Wound Care Evaluation Study at Maimonides (PRISM) - Pilot Study

McGill University

Effectiveness of Aromatherapy and Digital Anesthesia in Managing Dental Anxiety and Pain in Children

Turkey (Türkiye)

Arzu Pınar Erdem

The Efficacy and Safety of Pregabalin Combined With Toludesvenlafaxine in Patients With Fibromyalgia

Beijing Tiantan Hospital

The Effect of Storigami Method on Pain, Fear and Anxiety Levels Associated With Peripheral Intravenous Catheterisation in Children

Turkey (Türkiye)

NCT07301333 Phase 1

A Study of Single and Multiple Doses of HRS-6257 in Healthy Subjects

Shanghai Hengrui Pharmaceutica...

Transcutaneous Electrical Nerve Stimulation for Pain Mitigation During Intrauterine Device Placement

Medical University of South Ca...

The Warmth, Anticipation, Sensation, Aversion, and Body-part Imaging Study

Trustees of Dartmouth College

Spinal Cord Stimulation for Chronic Abdominal Pain Patients

The Leeds Teaching Hospitals N...

Use of Hand Extension Rubber During Intravenous Catheter Placement

Turkey (Türkiye)

Necmettin Erbakan University

Partial Breast Versus no Irradiation for Women With Early Breast Cancer

Chile, Denmark, Norw...

Danish Breast Cancer Cooperati...

Virtual Reality for Pain Management During Dupilumab Injection

St. Justine's Hospital

Pain Intervention With Needling: Pilot Of Integrated Neuromodulation Techniques

The University of Texas Medica...

Oklahoma Study of Native American Pain Risk III: Stress and Resilience

University of Oklahoma

Patient Reported Outcome Measurements Registration in Spinal Pathologies and Neuromodulation

NCT06290063 Phase 2

Cannabidiol and Older Adult Cannabis Users

University of Colorado, Boulde...

Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals

Virginia Polytechnic Institute...

NCT05883540 Phase 2

Lysergic Acid Diethylamide (LSD) in Palliative Care

University Hospital, Basel, Sw...

Related Conditions

quality of life (6) anxiety (5) depression (4) opioid use (2) opioid misuse (2) cervical pain (2) head and neck surgery (1) plastic surgery (1) rhinoplasty (1) regional anaesthesia (1) nerve blocks (1) shoulder pain (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology