NCT05151562 Music Therapy for Patients With Alzheimer's Disease
| NCT ID | NCT05151562 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Johns Hopkins University |
| Condition | Mild Cognitive Impairment |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2022-07-18 |
| Primary Completion | 2027-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2022-07-18 with a primary completion date of 2027-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study is designed to assess the feasibility that individualized reminiscence-based virtual music therapy sessions can enhance autobiographical memory, mood, and cognition in patients with mild cognitive impairment (MCI) or mild dementia due to Alzheimer's Disease (AD). 60 patients with MCI or mild dementia due to AD will receive two 30 minutes reminiscence-targeted virtual music therapy interventions per week for 8 weeks (a total of 16 sessions). Participants' (or supported by the study partner) self-reported and measurable outcomes including cognitive, anxiety, quality of life, and autobiographical memory will be assessed before and after the 8-week course of treatment. Blood-oxygenation level-dependent (BOLD) in functional magnetic resonance imaging (fMRI) will also be also measured before and after the 8-week course of treatment.
Eligibility Criteria
Inclusion Criteria: * Age 18-89 * Mild Cognitive Impairment (MoCA score: 18-25) or Early AD (MoCA score: 17-24) Exclusion Criteria: * Head trauma, traumatic brain injury, or concussion with loss of consciousness for \>2 minutes * Claustrophobia incompatible with MRI scanning * Medical device incompatible with MRI scanning (e.g. cardiac pacemaker, implanted cardiac defibrillator, aneurysm brain clip, inner ear implant) * Prior history as a metal worker and/or certain metallic objects in the body * Exclusion Criteria will be carefully determined by the MRI screening form.
Contact & Investigator
Alexander Pantelyat, MD
PRINCIPAL INVESTIGATOR
Department of Neurology, Johns Hopkins School of Medicine
Frequently Asked Questions
Who can join the NCT05151562 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 89 Years, studying Mild Cognitive Impairment. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05151562 currently recruiting?
Yes, NCT05151562 is actively recruiting participants. Contact the research team at apantel1@jhmi.edu for enrollment information.
Where is the NCT05151562 trial being conducted?
This trial is being conducted at Baltimore, United States.
Who is sponsoring the NCT05151562 clinical trial?
NCT05151562 is sponsored by Johns Hopkins University. The principal investigator is Alexander Pantelyat, MD at Department of Neurology, Johns Hopkins School of Medicine. The trial plans to enroll 60 participants.