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mild cognitive impairment

Total Trials
28
Recruiting Now
28
Trial Phases
Phase 1, Phase 2, EARLY_Phase 1

ClinicalMetric tracks all active clinical trials for mild cognitive impairment sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — mild cognitive impairment Clinical Trials

How many clinical trials are currently recruiting for mild cognitive impairment?
ClinicalMetric currently tracks 28 actively recruiting clinical trials for mild cognitive impairment, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 28. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for mild cognitive impairment?
mild cognitive impairment research spans Phase 1 (3 trials), Phase 2 (3 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a mild cognitive impairment clinical trial?
Eligibility criteria for mild cognitive impairment trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
3
Phase 2
3
Top Sponsors
Massachusetts General Hospital 2 trials
National University Hospital, Singapore 1 trial
University of Michigan 1 trial
Instituto de Investigación Marqués de Valdecilla 1 trial
Stanford University 1 trial

Recruiting Clinical Trials

NCT06983769
Recruiting
CPAP vs MAD for OSA in Patients With Cognitive Impairment. A Randomized Clinical Trial
Enrollment
260 pts
Location
Singapore
Sponsor
National University Hospital, ...
View Trial →
NCT06453980
Recruiting
Multimodal Investigation of Neural Plasticity
Enrollment
80 pts
Location
United States
Sponsor
University of Michigan
View Trial →
NCT06753578
Recruiting
Effectiveness of an ACT-Based Cognitive Intervention on Quality of Life and Cognitive Function in Elderly Residents With MCI
Enrollment
215 pts
Location
Spain
Sponsor
Instituto de Investigación Mar...
View Trial →
NCT06005038 Phase 1
Recruiting
CogT pSOPT Intervention Study
Enrollment
50 pts
Location
United States
Sponsor
Stanford University
View Trial →
NCT04938349
Recruiting
Dual Task Perturbation Training for OAwMCI
Enrollment
142 pts
Location
United States
Sponsor
University of Illinois at Chic...
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NCT06935812
Recruiting
Comparison of the Effects of Bimanual, Finger and VR Exercises in PwMCI
Enrollment
106 pts
Location
Cyprus
Sponsor
Eastern Mediterranean Universi...
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NCT03574207
Recruiting
Targeted Transcranial Magnetic Stimulation to Improve Hippocampal-dependent Declarative Memory Abilities
Enrollment
80 pts
Location
United States
Sponsor
University of Nebraska
View Trial →
NCT06201533
Recruiting
Low-intensity Physical-cognitive Exercise and Cognitive Function
Enrollment
64 pts
Location
Thailand
Sponsor
Chiang Mai University
View Trial →
NCT06072963 Phase 2
Recruiting
COMMETS- Combination MCI Metabolic Syndrome
Enrollment
80 pts
Location
Israel
Sponsor
Rutgers, The State University ...
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NCT06538311 EARLY_Phase 1
Recruiting
Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
Enrollment
30 pts
Location
United States
Sponsor
Massachusetts General Hospital
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NCT04525144 Phase 2
Recruiting
EGb 761 in the Syndrome of MCI With Concomitant CVD
Enrollment
134 pts
Location
Singapore
Sponsor
National Neuroscience Institut...
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NCT07296133
Recruiting
GAMES Intervention in MCI (Mild Cognitive Impairment)
Enrollment
124 pts
Location
United States
Sponsor
Emory University
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NCT05151562
Recruiting
Music Therapy for Patients With Alzheimer's Disease
Enrollment
60 pts
Location
United States
Sponsor
Johns Hopkins University
View Trial →
NCT06399731
Recruiting
Non-invasive Brain Stimulation for the Treatment of Mild Cognitive Impairment in Parkinson's Disease
Enrollment
20 pts
Location
Netherlands
Sponsor
Amsterdam UMC
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NCT07485725
Recruiting
Digital Tools to Support Healthcare Decision Making
Enrollment
120 pts
Location
United States
Sponsor
Weill Medical College of Corne...
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NCT06307574
Recruiting
bpMedManage: Digital Technology to Support Adherence to Hypertension Medications
Enrollment
100 pts
Location
United States
Sponsor
University of Arizona
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NCT06122415
Recruiting
The Swedish BioFINDER - Memory Clinic Study
Enrollment
1,200 pts
Location
Sweden
Sponsor
Skane University Hospital
View Trial →
NCT05446584 Phase 2
Recruiting
Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History
Enrollment
75 pts
Location
United States
Sponsor
University of Texas Southweste...
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NCT05396248
Recruiting
Improve New Learning and Memory in Individuals With Mild Cognitive Impairment
Enrollment
120 pts
Location
United States
Sponsor
Kessler Foundation
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NCT05710549
Recruiting
Understanding Brain Mechanisms Involved in Autobiographical Memory
Enrollment
120 pts
Location
Switzerland
Sponsor
Lucie Bréchet
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NCT06040905
Recruiting
Causal Effect of Coenzyme Q10 Nutrition and Cognitive Dysfunction in the Metabolic Storm (Hyperglycemia and Sarcopenia) and Brain-derived Neurotrophic Factor
Enrollment
100 pts
Location
Taiwan
Sponsor
Chung Shan Medical University
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NCT06444841
Recruiting
Paper-Based and Smartphone-Based Memory Supports
Enrollment
200 pts
Location
United States
Sponsor
Baylor University
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NCT04916210
Recruiting
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
Enrollment
8,000 pts
Location
United States
Sponsor
Massachusetts General Hospital
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NCT02420470
Recruiting
The Early Warning System for the Diabetic Encephalopathy
Enrollment
300 pts
Location
China
Sponsor
Tang-Du Hospital
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NCT05887674
Recruiting
Shanghai Non-pharmacological Intervention for Mild Cognitive Impairment and Mild Alzheimer's Disease
Enrollment
180 pts
Location
China
Sponsor
Ruijin Hospital
View Trial →
NCT06453746
Recruiting
Effectiveness of Non-pharmacological Interventions for Dementia Prevention in Elderly Patients With Mild Cognitive Impairment
Enrollment
192 pts
Location
Vietnam
Sponsor
Gia Dinh People Hospital
View Trial →
NCT06413173
Recruiting
Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
Enrollment
160 pts
Location
United States
Sponsor
United States Naval Medical Ce...
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NCT04396873 Phase 1
Recruiting
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
Enrollment
184 pts
Location
United States
Sponsor
National Institute of Mental H...
View Trial →

Related Conditions

alzheimer disease (7) memory loss (2) mild dementia (2) mild traumatic brain injury (2) obstructive sleep apnea osa (1) subjective cognitive impairment (1) old age debility (1) metabolic syndrome (1) logopenic progressive aphasia (1) amnestic symptoms (1) cerebrovascular disease (1) parkinson disease (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology