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Johns Hopkins University

Total Trials

Recruiting

Phases

Phase 1, Phase 2, Phase 3, Phase 4, Phase 2, Phase 3, Phase 1, Phase 2

Conditions studied: Tobacco Use Tobacco Smoking Tobacco Dependence Tobacco Use Disorder Tobacco Use Cessation Osteoporosis Arthroplasty Complications Fragility Fracture Adolescent Alcohol Use Cannabis Use Disorder

Johns Hopkins University is one of the premier academic medical research institutions in the United States and globally, consistently ranked among the top NIH-funded institutions. The Johns Hopkins School of Medicine and the Bloomberg School of Public Health together support one of the most diverse clinical trial portfolios in US academic medicine, spanning infectious disease, oncology, cardiology, neurology, psychiatry, ophthalmology, and population health. Johns Hopkins Hospital — one of the nation's oldest and most respected teaching hospitals — serves as the primary trial site for Hopkins-initiated studies.

Hopkins has a long tradition of trial leadership in HIV/AIDS (through the Bloomberg School's International Health division and the Baltimore cohort studies), cancer (through the Johns Hopkins Kimmel Cancer Center, an NCI-designated comprehensive cancer center), and cardiovascular disease (through the Ciccarone Center for the Prevention of Cardiovascular Disease). Hopkins investigators have led landmark studies including the Physicians' Health Study, the SPRINT blood pressure trial, and pivotal work on HPV vaccine efficacy in partnership with the NCI.

Johns Hopkins also serves as a primary site for global health trials — particularly in low- and middle-income countries — in tuberculosis, malaria, neonatal health, and maternal nutrition. The Johns Hopkins Center for Clinical Trials is a federally designated Clinical and Translational Science Award (CTSA) hub, providing infrastructure, biostatistics support, and regulatory expertise for more than 400 concurrent investigator-initiated and sponsor-initiated trials across the institution.

Frequently Asked Questions — Johns Hopkins University

What cancer clinical trials does Johns Hopkins University sponsor or lead?

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins is NCI-designated and runs active trials in colorectal cancer (including investigational immunotherapy for mismatch repair-deficient tumors — a breakthrough area pioneered at Hopkins), pancreatic cancer, prostate cancer, brain tumors, leukemia and lymphoma, and lung cancer. Hopkins investigators have led multiple NCI cooperative group trials and have an internationally recognized program in cancer immunoprevention — developing vaccine strategies to prevent cancer in high-risk populations. The institution also conducts first-in-human Phase 1 trials through its Drug Development Core.

Does Johns Hopkins conduct clinical trials for neurological or psychiatric conditions?

Yes. The Johns Hopkins Department of Psychiatry and Behavioral Sciences has an active research program that includes trials on treatment-resistant depression (including psilocybin-assisted therapy — one of the first institutional programs in the US to receive DEA approval for this research), PTSD, addiction medicine (including novel treatments for opioid use disorder), and bipolar disorder. The Department of Neurology runs trials in multiple sclerosis (through the Johns Hopkins MS Center), ALS, Parkinson's disease, and stroke. The Wilmer Eye Institute at Hopkins — one of the top-ranked ophthalmology programs in the world — sponsors trials in macular degeneration, glaucoma, and inherited retinal diseases.

How do patients access Johns Hopkins clinical trials from outside Maryland?

Many Johns Hopkins trials are part of multicenter networks that include enrollment sites at hospitals and clinics nationwide — particularly NCI cooperative group trials conducted through ECOG-ACRIN, the Alliance, or NCI NCTN. For trials that are Hopkins-only, patients often travel to the Johns Hopkins Hospital campus in Baltimore, Maryland. The Hopkins Clinical Research Trials Office (410-502-9100) and the JH clinical trials search engine (trials.hopkinsmedicine.org) can help patients identify open trials and assess eligibility before visiting. Hopkins also offers telehealth pre-screening appointments for some trials.

Johns Hopkins University

Frequently Asked Questions — Johns Hopkins University

Clinical Trials by Johns Hopkins University

Oral Cannabidiol for Tobacco Cessation

Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty

Brief Motivational Interviewing +/- Mindfulness Training for Adolescent Alcohol Use in Pediatric Primary Care

Psilocybin-assisted Treatment for Cannabis Use Disorder

Night Owl Metabolism

Effects of Simvastatin on Uterine Leiomyoma Size

Solriamfetol for the Treatment of Multiple Sclerosis Fatigue

Pharmacokinetics and Pharmacodynamics of CHI-914 in Healthy Participants

Preliminary Characterization of Commercial Kratom Extract Products

Investigation on the Cortical Communication (CortiCom) System

Vortioxetine for the Treatment of Mood and Cognitive Symptoms in Frontotemporal Dementia

Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)

Reducing Vertigo Associated With MRI Machines

Full-Field Optical Coherence Tomography (FFOCT) for Evaluation of Bronchoscopic Small Biopsy Specimens

The Cancer of the Pancreas Screening-5 CAPS5)Study

Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder

Dupilumab De-escalation in Pediatric Atopic Dermatitis

Evaluation of Single Dosing With Two F/TAF Tablets Among Healthy Volunteers

Trial to Determine Effective Aspirin Dose in COPD

Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder

Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for SAH

Strategies to AchieVe Viral Suppression for Youth With HIV

Transrectal Ultrasound Robot-Assisted Prostate Biopsy

Dolutegravir/Lamivudine Dual Therapy for ART-naïve People With HIV and TB Receiving Rifampin-based TB Treatment

CORE-COMPARE Pilot Study

OMEGA - Dietary Intervention - COPD Trial

Scrambler Therapy for Corticobasal Syndrome-Associated Pain

Estrogen Supplementation and Bone Health in Women With CF

Tesamorelin to Improve Functional Outcomes After Peripheral Nerve Injury

CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

Use of Steroid Injections to Prevent the Recurrence of Tracheal Stenosis in Idiopathic Subglottic Stenosis

Human Penile Allotransplantation

Deep Functional Phenotyping of the ALA Lung Health Cohort

The Integrated Female Sexually Transmitted Infection Testing for HIV Epidemic Control Through PrEP (IN-STEP) Study

Impact of Manual Therapy on Laryngeal Function Following Total Thyroidectomy

Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought

Pregnenolone as a Treatment for Cannabis Intoxication

The Effects of One-time Intraoperative Methadone During Laparoscopic Hysterectomy in Reducing Opioid Prescription.