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Johns Hopkins University

Total Trials

Recruiting

Phases

Phase 2, Phase 3, Phase 3, Phase 2, Phase 1, Phase 4

Conditions studied: Tuberculosis, Latent HIV HIV Infections Alzheimer Disease Dementia Hearing Loss Cognitive Impairment Bilateral Vestibular Hypofunction Bilateral Vestibular Deficiency Bilateral Vestibulopathy

Johns Hopkins University is one of the premier academic medical research institutions in the United States and globally, consistently ranked among the top NIH-funded institutions. The Johns Hopkins School of Medicine and the Bloomberg School of Public Health together support one of the most diverse clinical trial portfolios in US academic medicine, spanning infectious disease, oncology, cardiology, neurology, psychiatry, ophthalmology, and population health. Johns Hopkins Hospital — one of the nation's oldest and most respected teaching hospitals — serves as the primary trial site for Hopkins-initiated studies.

Hopkins has a long tradition of trial leadership in HIV/AIDS (through the Bloomberg School's International Health division and the Baltimore cohort studies), cancer (through the Johns Hopkins Kimmel Cancer Center, an NCI-designated comprehensive cancer center), and cardiovascular disease (through the Ciccarone Center for the Prevention of Cardiovascular Disease). Hopkins investigators have led landmark studies including the Physicians' Health Study, the SPRINT blood pressure trial, and pivotal work on HPV vaccine efficacy in partnership with the NCI.

Johns Hopkins also serves as a primary site for global health trials — particularly in low- and middle-income countries — in tuberculosis, malaria, neonatal health, and maternal nutrition. The Johns Hopkins Center for Clinical Trials is a federally designated Clinical and Translational Science Award (CTSA) hub, providing infrastructure, biostatistics support, and regulatory expertise for more than 400 concurrent investigator-initiated and sponsor-initiated trials across the institution.

Frequently Asked Questions — Johns Hopkins University

What cancer clinical trials does Johns Hopkins University sponsor or lead?

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins is NCI-designated and runs active trials in colorectal cancer (including investigational immunotherapy for mismatch repair-deficient tumors — a breakthrough area pioneered at Hopkins), pancreatic cancer, prostate cancer, brain tumors, leukemia and lymphoma, and lung cancer. Hopkins investigators have led multiple NCI cooperative group trials and have an internationally recognized program in cancer immunoprevention — developing vaccine strategies to prevent cancer in high-risk populations. The institution also conducts first-in-human Phase 1 trials through its Drug Development Core.

Does Johns Hopkins conduct clinical trials for neurological or psychiatric conditions?

Yes. The Johns Hopkins Department of Psychiatry and Behavioral Sciences has an active research program that includes trials on treatment-resistant depression (including psilocybin-assisted therapy — one of the first institutional programs in the US to receive DEA approval for this research), PTSD, addiction medicine (including novel treatments for opioid use disorder), and bipolar disorder. The Department of Neurology runs trials in multiple sclerosis (through the Johns Hopkins MS Center), ALS, Parkinson's disease, and stroke. The Wilmer Eye Institute at Hopkins — one of the top-ranked ophthalmology programs in the world — sponsors trials in macular degeneration, glaucoma, and inherited retinal diseases.

How do patients access Johns Hopkins clinical trials from outside Maryland?

Many Johns Hopkins trials are part of multicenter networks that include enrollment sites at hospitals and clinics nationwide — particularly NCI cooperative group trials conducted through ECOG-ACRIN, the Alliance, or NCI NCTN. For trials that are Hopkins-only, patients often travel to the Johns Hopkins Hospital campus in Baltimore, Maryland. The Hopkins Clinical Research Trials Office (410-502-9100) and the JH clinical trials search engine (trials.hopkinsmedicine.org) can help patients identify open trials and assess eligibility before visiting. Hopkins also offers telehealth pre-screening appointments for some trials.

Johns Hopkins University

Frequently Asked Questions — Johns Hopkins University

Clinical Trials by Johns Hopkins University

Bedaquiline Roll-out Evidence in Contacts and People Living With HIV to Prevent TB

Skeletal Muscle Energetics and Fatiguability in Older Individuals

HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms

Long Term Outcomes After Vestibular Implantation

Effects of Recorded Music on Clinical and EEG Seizure Activity

Trial to Determine Effective Aspirin Dose in COPD

Vibrotactile Balance Belt Effect on Improving Gait

Bring BPaL2Me Trial Comparing Nurse-Led RR-TB Treatment to Physician-Led RR-TB Treatment

Imaging Techniques for Identifying Factors of Sudden Cardiac Death Risk

Metformin IN Asthma for Overweight and Obese Individuals (MINA)

Phase 4 of Designed With You

What Works to Prevent Violence Against Women and Girls in Somalia

The Impact of Low Sodium Salt Substitute Use on Serum Potassium Levels Among Patients With Hypertension

Nutrition Optimization and Community Upliftment for Postpartum Recovery

Human Upper Extremity Allotransplantation: F/U Protocol

Strategies to AchieVe Viral Suppression for Youth With HIV

1MoreStep: An Intervention to Increase HIV Care Engagement and Reduce Intimate Partner Violence Among Black Women Living With HIV

Brief Motivational Interviewing +/- Mindfulness Training for Adolescent Alcohol Use in Pediatric Primary Care

A Cardiometabolic Health Program Linked With Clinical-Community Support and Mobile Health Telemonitoring to Reduce Health Disparities

Evaluating Smoking Cessation Interventions for PWH in South Africa

Music Therapy for Patients With Alzheimer's Disease

Psilocybin-assisted Treatment for Cannabis Use Disorder

External Post-Operative Skull Prosthesis to Prevent Sunken Flap Syndrome in Craniectomy Patients

Improving Health for Patients With Chronic Low Back Pain in Rural Communities Through Telerehabilitation

Groceries Plus Multi-Component Lifestyle Intervention for Adults With Hypertension and Type 2 Diabetes

Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)

Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study

High Relaxivity Contrast Agent for Cardiac MR in the Myocardial Scar Assessment

Left Ventricular Structural Predictors of Sudden Cardiac Death

Prophylaxis With Direct-acting Antivirals for Kidney Transplantation From HCV-Infected Donors to Uninfected Recipients

Isturisa Treatment in Mild Autonomous Cortisol Secretion( MACS)

Incorporation of Safe Sleep Education Into m-Health Technology

Investigation on the Bidirectional Cortical Neuroprosthetic System

Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure

Parenting for Tomorrow: A New Model for Supporting Preschool Children's Mental Health in Head Start

Achondroplasia Natural History Multicenter Clinical Study

5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder

Human Upper Extremity Allotransplantation

Evaluating Safety and Efficacy of Prostate-sparing Radical Cystectomy

Liver Transplantation From Donors With HIV: Impact on Opportunistic Infections, Cancer, and Long-Term Outcomes (Expanding HOPE Liver)

Economic Incentives and vDOT for Latent Tuberculosis Infection

Group Postpartum and Well-Child Care for Maternal and Infant Health