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Johns Hopkins University

Total Trials
27
Recruiting
27
Phases
Phase 2, Phase 1, EARLY_Phase 1, Phase 4

Johns Hopkins University is one of the premier academic medical research institutions in the United States and globally, consistently ranked among the top NIH-funded institutions. The Johns Hopkins School of Medicine and the Bloomberg School of Public Health together support one of the most diverse clinical trial portfolios in US academic medicine, spanning infectious disease, oncology, cardiology, neurology, psychiatry, ophthalmology, and population health. Johns Hopkins Hospital — one of the nation's oldest and most respected teaching hospitals — serves as the primary trial site for Hopkins-initiated studies.

Hopkins has a long tradition of trial leadership in HIV/AIDS (through the Bloomberg School's International Health division and the Baltimore cohort studies), cancer (through the Johns Hopkins Kimmel Cancer Center, an NCI-designated comprehensive cancer center), and cardiovascular disease (through the Ciccarone Center for the Prevention of Cardiovascular Disease). Hopkins investigators have led landmark studies including the Physicians' Health Study, the SPRINT blood pressure trial, and pivotal work on HPV vaccine efficacy in partnership with the NCI.

Johns Hopkins also serves as a primary site for global health trials — particularly in low- and middle-income countries — in tuberculosis, malaria, neonatal health, and maternal nutrition. The Johns Hopkins Center for Clinical Trials is a federally designated Clinical and Translational Science Award (CTSA) hub, providing infrastructure, biostatistics support, and regulatory expertise for more than 400 concurrent investigator-initiated and sponsor-initiated trials across the institution.

Frequently Asked Questions — Johns Hopkins University

What cancer clinical trials does Johns Hopkins University sponsor or lead?
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins is NCI-designated and runs active trials in colorectal cancer (including investigational immunotherapy for mismatch repair-deficient tumors — a breakthrough area pioneered at Hopkins), pancreatic cancer, prostate cancer, brain tumors, leukemia and lymphoma, and lung cancer. Hopkins investigators have led multiple NCI cooperative group trials and have an internationally recognized program in cancer immunoprevention — developing vaccine strategies to prevent cancer in high-risk populations. The institution also conducts first-in-human Phase 1 trials through its Drug Development Core.
Does Johns Hopkins conduct clinical trials for neurological or psychiatric conditions?
Yes. The Johns Hopkins Department of Psychiatry and Behavioral Sciences has an active research program that includes trials on treatment-resistant depression (including psilocybin-assisted therapy — one of the first institutional programs in the US to receive DEA approval for this research), PTSD, addiction medicine (including novel treatments for opioid use disorder), and bipolar disorder. The Department of Neurology runs trials in multiple sclerosis (through the Johns Hopkins MS Center), ALS, Parkinson's disease, and stroke. The Wilmer Eye Institute at Hopkins — one of the top-ranked ophthalmology programs in the world — sponsors trials in macular degeneration, glaucoma, and inherited retinal diseases.
How do patients access Johns Hopkins clinical trials from outside Maryland?
Many Johns Hopkins trials are part of multicenter networks that include enrollment sites at hospitals and clinics nationwide — particularly NCI cooperative group trials conducted through ECOG-ACRIN, the Alliance, or NCI NCTN. For trials that are Hopkins-only, patients often travel to the Johns Hopkins Hospital campus in Baltimore, Maryland. The Hopkins Clinical Research Trials Office (410-502-9100) and the JH clinical trials search engine (trials.hopkinsmedicine.org) can help patients identify open trials and assess eligibility before visiting. Hopkins also offers telehealth pre-screening appointments for some trials.

Clinical Trials by Johns Hopkins University

NCT07157995
Recruiting

Phase 4 of Designed With You

Disability Physical
NCT07216690 Phase 2
Recruiting

Pregnenolone as a Treatment for Cannabis Intoxication

Cannabis Intoxication
NCT07349758 Phase 1
Recruiting

Evaluation of Single Dosing With Two F/TAF Tablets Among Healthy Volunteers

Healthy Volunteer
NCT05671718
Recruiting

Bring BPaL2Me Trial Comparing Nurse-Led RR-TB Treatment to Physician-Led RR-TB Treatment

Drug Resistant Tuberculosis
NCT05672615
Recruiting

Mood Alterations in the Patients With Non-Muscle Invasive Bladder Cancer Treated With BCG

Non-Muscle Invasive Bladder Cancer
NCT06847685
Recruiting

Mechanisms of Uterine Fluid Absorption During Early Pregnancy ( ELF Study)

Endometriosis
NCT06170541
Recruiting

CORE-COMPARE Pilot Study

Coronary Heart Disease (CHD)
NCT04473794
Recruiting

Diagnostic Strategies, Risk Assessment and Progression of Pancreatic Cysts

Pancreatic Neoplasms
NCT05171478
Recruiting

Full-Field Optical Coherence Tomography (FFOCT) for Evaluation of Bronchoscopic Small Biopsy Specimens

Lung Cancer
NCT07778810 Phase 2
Recruiting

Epidiolex Trial for Presymptomatic Treatment of Sturge-Weber Syndrome

Sturge - Weber Syndrome (SWS)
NCT04123314 EARLY_Phase 1
Recruiting

Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease

Depressive Symptoms
NCT04142047
Recruiting

Skeletal Muscle Energetics and Fatiguability in Older Individuals

HIV
NCT07425535 EARLY_Phase 1
Recruiting

Optic Nerve Head Strain in Non-glaucoma Subjects

Glaucoma
NCT06408142
Recruiting

Universal Test and Connect for HIV Service Delivery in South Africa

Human Immunodeficiency Virus
NCT07734870 Phase 2
Recruiting

Tirzepatide for Treatment of CCCA

Central Centrifugal Cicatricial Alopecia (CCCA)
NCT06500988
Recruiting

Mobile Health Technology-Enabled AFib Management

Atrial Fibrillation
NCT07164742
Recruiting

Parent Study Name: Pulmonary Rehabilitation to Reduce Post-Tuberculosis Morbidity (TB Pure)

TB - Tuberculosis
NCT05703386
Recruiting

Imaging the Pathogenesis of Cerebral Small Vessel Disease

Ischemic Stroke
NCT04797286 Phase 2
Recruiting

Sildenafil for Early Pulmonary Vascular Disease in Scleroderma

Scleroderma
NCT06299436
Recruiting

Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure

Heart Failure With Reduced Ejection Fraction
NCT07174609
Recruiting

Scrambler Therapy in Chronic Pancreatitis

Chronic Pain
NCT01889381 Phase 2
Recruiting

Human Craniomaxillofacial Allotransplantation

Facial Injuries
NCT06886971
Recruiting

Strategies to AchieVe Viral Suppression for Youth With HIV

Human Immunodeficiency Virus (HIV) Infection
NCT07064837
Recruiting

Utilizing Pediatric Primary Care Connections to Advance Reproductive Health

Contraceptive Use
NCT06103370
Recruiting

Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation

HIV Infections
NCT07389590 Phase 4
Recruiting

Study of Ublituximab for Ocrelizumab Wearing-Off in Multiple Sclerosis

Multiple Sclerosis
NCT05795634
Recruiting

Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease

Mild Cognitive Impairment
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology