NCT05079464 Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)
| NCT ID | NCT05079464 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Sunnybrook Health Sciences Centre |
| Condition | Vascular Cognitive Impairment |
| Study Type | INTERVENTIONAL |
| Enrollment | 64 participants |
| Start Date | 2021-11-22 |
| Primary Completion | 2026-09 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 64 participants in total. It began in 2021-11-22 with a primary completion date of 2026-09.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
People with vascular conditions are at risk of having memory problems, and these memory problems increase the risk for further cognitive decline. Brain stimulation has been used to improve mood and memory. Transcranial direct current stimulation (tDCS) is believed to work best on brain cells that are active or "primed" before stimulation. The purpose of this study is to compare the effects of exercise and tDCS on memory performance in patients who have completed cardiac rehabilitation and are at risk of cognitive decline.
Eligibility Criteria
Inclusion Criteria: * ≥50 years of age; females must be post-menopausal * Presence of cerebrovascular and/or cardiovascular risk factors or coronary artery disease * Montreal Cognitive Assessment (MoCA) \<27 * Sufficiently proficient in English * Must be able to exercise at a moderate intensity level * Presence of modest deficits (1 standard deviation below population norm) in one of the following domains: executive function, verbal memory, working memory, or visuospatial memory Exclusion Criteria: * History of stroke * Change in psychotropics within the last 4 weeks * Current benzodiazepine use due * Metal implants that would preclude safe use of tDCS or neuroimaging * Significant neurological or psychiatric conditions (current major depressive disorder, bipolar disorder, schizophrenia) * MoCA \<18 and/or clinical diagnosis of dementia * Any medical contraindications to exercise
Contact & Investigator
Krista Lanctôt, PhD
PRINCIPAL INVESTIGATOR
Sunnybrook Research Institute
Frequently Asked Questions
Who can join the NCT05079464 clinical trial?
This trial is open to participants of all sexes, aged 50 Years or older, studying Vascular Cognitive Impairment. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05079464 currently recruiting?
Yes, NCT05079464 is actively recruiting participants. Contact the research team at mehreen.siddiqui@sri.utoronto.ca for enrollment information.
Where is the NCT05079464 trial being conducted?
This trial is being conducted at Toronto, Canada.
Who is sponsoring the NCT05079464 clinical trial?
NCT05079464 is sponsored by Sunnybrook Health Sciences Centre. The principal investigator is Krista Lanctôt, PhD at Sunnybrook Research Institute. The trial plans to enroll 64 participants.