Exploring Approaches With Lower Targets of Blood Pressure and Lipid for Improving Renal Outcome in Advanced Chronic Kidney Disease
Trial Parameters
Brief Summary
The purpose of this study is to prevent kidney disease progression in adults with advanced chronic kidney disease (estimated glomerular filtration rate \[eGFR\] between 15-45 mL/min/1.73 m2) using intensive blood pressure control and intensive lipid management with 2X2 factorial design.
Eligibility Criteria
Inclusion Criteria: * Fulfillment of all of followings 1. At least 19 years old 2. Evidence of CKD defined at least 3 months before and at the time of screening visit with CKD-EPI eGFR ≥15 to \<45 mL/min/1.73 m2 3. SBP of * 130-180 mmHg on 0 or 1 medication * 130-170 mmHg on upto 2 medications * 130-160 mmHg on more than 3 medications 4. LDL-C ≥100 mg/dL Exclusion Criteria: * Any of followings 1. Resistant hypertension or poorly controlled hypertension * Failure to achieve SBP of \<140 mmHg despite using 4 or more antihypertensive medications including diuretics 2. Known secondary cause of hypertension 3. History of renal devervation procedure 4. Glomerulonephritis requiring immunosuppresive agents 5. Autosomal dominant polycystic kidney disease receiving tolvaptan 6. CKD-EPI \< 15 mL/min/1.73 m2 or receiving kidney replacement therapy 7. Familial hypercholesterolemia 8. Cardiovascular event or precedure (as defined as myocardial infarction, unstable angina, coronary revascularization,