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Medical Condition
chronic kidney diseases
Total Trials
4
Recruiting Now
4
Trial Phases
EARLY_Phase 1, Phase 4
Chronic kidney disease (CKD) and end-stage renal disease trials have been revitalized by SGLT2 inhibitors, which reduce CKD progression in both diabetic and non-diabetic patients through hemodynamic and anti-inflammatory mechanisms beyond glucose lowering. Targeting residual risk after SGLT2 and RAAS inhibition is the current frontier, with mineralocorticoid receptor antagonists (finerenone) already approved.
Active trials evaluate sparsentan (dual endothelin-angiotensin antagonist) in IgAN, iptacopan for complement-mediated nephropathy, bardoxolone for Alport syndrome, and dicarba-based gene therapy for FSGS. Urine biomarkers (UACR, NGAL) and eGFR slope are standard endpoints, with surrogate-to-hard endpoint validation ongoing.
Frequently Asked Questions — chronic kidney diseases Clinical Trials
How many clinical trials are currently recruiting for chronic kidney diseases?
ClinicalMetric currently tracks 4 actively recruiting clinical trials for chronic kidney diseases, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 4. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for chronic kidney diseases?
chronic kidney diseases research spans Phase 1 (1 trial), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a chronic kidney diseases clinical trial?
Eligibility criteria for chronic kidney diseases trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1 1
Phase 4 1
Top Sponsors
1 trial
1 trial
1 trial
1 trial
Recruiting Clinical Trials
NCT05321368
Recruiting
A Cardiometabolic Health Program Linked With Clinical-Community Support and Mobile Health Telemonitoring to Reduce Health Disparities
Enrollment
425 pts
Location
United States
Sponsor
Johns Hopkins University
NCT04592640 EARLY_Phase 1
Recruiting
Human Amniotic-Derived Mesenchymal Stem Cell Therapy for Calciphylaxis
Enrollment
9 pts
Location
China
Sponsor
The First Affiliated Hospital ...
NCT06560801 Phase 4
Recruiting
Dapagliflozin on Renal Morphology and Renal Perfusion in Patients One Year After Kidney Transplantation
Enrollment
48 pts
Location
Germany
Sponsor
University of Erlangen-Nürnber...
NCT06463483
Recruiting
Automated Insulin Delivery in Adults With Advanced Kidney Disease
Enrollment
12 pts
Location
United Kingdom
Sponsor
Imperial College London
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology