NCT07883720 EXercise-induced PhysioLogical Adaptations In Neurological Disorders
| NCT ID | NCT07883720 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Brigham and Women's Hospital |
| Condition | Epilepsy |
| Study Type | INTERVENTIONAL |
| Enrollment | 240 participants |
| Start Date | 2026-07-22 |
| Primary Completion | 2029-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 240 participants in total. It began in 2026-07-22 with a primary completion date of 2029-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers. The main questions the study aims to answer are: * How do fitness level, exercise performance, and physical exhaustion differ between patients with neurological diseases and healthy participants? * How does acute exercise affect brain function and other physiological biomarkers in participants with neurological diseases? Participants will take part in a single, one-day study visit and will be asked to: * Perform a standardized exercise test on a bicycle ergometer * Undergo a brain MRI (magnetic resonance imaging) scan, a blood draw, and autonomic measurements before and after the exercise test
Eligibility Criteria
Inclusion Criteria: * 18 years or older * Clinical diagnosis of one of the following neurological diseases: epilepsy, functional neurological disorder, mild cognitive impairment, dementia, Parkinson's disease, concussion, brain tumor \[for participants with neurological diseases\] * No diagnosis of neurological disease \[for healthy control participants\] Exclusion Criteria: * Non-english speaking individuals * Exercise contraindications (e.g., physical impairments limiting use of bicycle ergometer, acute infections, severe heart disease, uncontrolled hypertension, exercise associated seizures) * Current use of medications for cardiac rhythm or rate control * Magnetic resonance imaging (MRI) contraindications (e.g., electrical implants, ferromagnetic implants or objects, pregnancy)
Contact & Investigator
Claus Reinsberger, MD, PhD
PRINCIPAL INVESTIGATOR
Brigham and Women's Hospital
Frequently Asked Questions
Who can join the NCT07883720 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Epilepsy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07883720 currently recruiting?
Yes, NCT07883720 is actively recruiting participants. Contact the research team at creinsberger@mgb.org for enrollment information.
Where is the NCT07883720 trial being conducted?
This trial is being conducted at Boston, United States.
Who is sponsoring the NCT07883720 clinical trial?
NCT07883720 is sponsored by Brigham and Women's Hospital. The principal investigator is Claus Reinsberger, MD, PhD at Brigham and Women's Hospital. The trial plans to enroll 240 participants.
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