NCT06393179 Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients
| NCT ID | NCT06393179 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Southeast University, China |
| Condition | Mechanical Ventilation Pressure High |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2024-05-30 |
| Primary Completion | 2024-08-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2024-05-30 with a primary completion date of 2024-08-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Monitoring airway pressure is essential for patients with mechanical ventilation. However, static airway pressure does not reflect alveolar pressure at all. Airway pressure is supposed to completely interrupt the communication between proximal airway opening and the distal alveolar and/or small airway structures. In this condition, some alveoli may still be inflated but do not communicate with proximal airways and auto-PEEP will give a biased estimated of mean alveolar pressure. To be note, distinguishing the airway closure and alveolar collapse can be challenging at times. The quasi-static PV curve is a useful bedside tool to set mechanical ventilation, which may help us to identify the airway closure and alveolar collapse. Meanwhile, the quasi-static PV curve can only reflects a global behaviour of the lung, while EIT may be a useful tool to assess the regional information on airway closure and alveolar collapse.
Eligibility Criteria
Inclusion Criteria: * Adult patients undergoing controlled mechanical ventilation * The duration of endotracheal intubation \< 48 hrs Exclusion Criteria: * Severe hemodynamic instability * Severe chronic lung disease requiring long-term home oxygen therapy * Patients without analgesic sedation * Decline to participate in the study * Refusal to sign informed consent
Contact & Investigator
ling liu
PRINCIPAL INVESTIGATOR
Zhongda Hospital
Frequently Asked Questions
Who can join the NCT06393179 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Mechanical Ventilation Pressure High. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06393179 currently recruiting?
Yes, NCT06393179 is actively recruiting participants. Contact the research team at liulingdoctor@126.com for enrollment information.
Where is the NCT06393179 trial being conducted?
This trial is being conducted at Nanjing, China.
Who is sponsoring the NCT06393179 clinical trial?
NCT06393179 is sponsored by Southeast University, China. The principal investigator is ling liu at Zhongda Hospital. The trial plans to enroll 60 participants.