NCT05098717 End-expiratory Trans-pulmonary Pressure Guided PEEP Titration in Patients With Pulmonary Fibrosis and UIP Pattern Undergoing Mechanical Ventilation
| NCT ID | NCT05098717 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Modena and Reggio Emilia |
| Condition | Idiopathic Pulmonary Fibrosis |
| Study Type | OBSERVATIONAL |
| Enrollment | 40 participants |
| Start Date | 2023-02-08 |
| Primary Completion | 2026-01-01 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 40 participants in total. It began in 2023-02-08 with a primary completion date of 2026-01-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Patients with pulmonary fibrosis and associated usual interstitial pneumonia that require mechanical ventilation for acute respiratory failure experience poor clinical outcomes. This may be influenced by the unfavorable interaction between the fibrotic lung and the stress and strain stimuli generated during controlled ventilation. Although there is no consensus on how to ventilate these patients, much of the recommendations followed in clinical practice are taken from the experience on patients with acute respiratory distress syndrome. Among these, measuring the esophageal pressures and adjusting positive-end expiatory pressure to make trans-pulmonary pressures positive can decrease atelectasis, derecruitment of lung, and cyclical opening and closing of airways and alveoli, thus optimizing lung mechanics and oxygenation. The effect of this strategy on the fibrotic lung has not yet been documented. With this observational study we aim at documenting the effect of PEEP titration maneuver based on end-expiratory trans-pulmonary pressure on lung mechanics of patients with pulmonary fibrosis and UIP pattern,
Eligibility Criteria
Inclusion Criteria: * pulmonary fibrosis with UIP pattern * subjected to endotracheal intubation and controlled mechanical ventilation for acute respiratory failure * candidate to a trial of PEEP titration according to positive end expiratory pressure. Exclusion Criteria: * chest wall deformities * chronic obstructive pulmonary disease
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05098717 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 90 Years, studying Idiopathic Pulmonary Fibrosis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05098717 currently recruiting?
Yes, NCT05098717 is actively recruiting participants. Contact the research team at roberto.tonelli@me.com for enrollment information.
Where is the NCT05098717 trial being conducted?
This trial is being conducted at Modena, Italy.
Who is sponsoring the NCT05098717 clinical trial?
NCT05098717 is sponsored by University of Modena and Reggio Emilia. The trial plans to enroll 40 participants.