NCT07248072 Effect of iPACK and BiFeS Blocks on Quality of Recovery After Total Knee Arthroplasty
| NCT ID | NCT07248072 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Ataturk University |
| Condition | Knee Osteoarthritis |
| Study Type | INTERVENTIONAL |
| Enrollment | 74 participants |
| Start Date | 2025-12-01 |
| Primary Completion | 2026-07-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 74 participants in total. It began in 2025-12-01 with a primary completion date of 2026-07-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This prospective, randomized, double-blind clinical trial aims to compare the effects of two different posterior knee analgesia techniques-iPACK block (Interspace Between the Popliteal Artery and the Capsule of the posterior Knee) and the Biceps Femoris Short Head (BiFeS) block-when combined with an adductor canal block (ACB) in patients undergoing elective unilateral total knee arthroplasty (TKA). Effective postoperative analgesia is essential for early mobilization, enhanced recovery, and patient satisfaction after TKA. Although ACB provides good anterior knee analgesia while preserving quadriceps strength, additional posterior knee analgesia is often required. The iPACK block is a commonly used technique that targets the posterior knee capsule, whereas the newer BiFeS block aims to provide more selective posterolateral sensory blockade with potentially reduced risk of motor involvement. However, comparative clinical data between these two techniques are limited. The primary objective of this study is to evaluate the difference between the iPACK and BiFeS blocks in terms of Quality of Recovery-15 (QoR-15) scores at 24 hours postoperatively. Secondary objectives include comparisons of postoperative pain scores, opioid consumption, time to first analgesic request, quadriceps and anterior tibialis muscle strength, functional test performance, time to mobilization, active range of motion, and the incidence of adverse events. A total of 74 adult patients scheduled for elective unilateral TKA under spinal anesthesia will be randomized in a 1:1 ratio into two groups: ACB + iPACK block or ACB + BiFeS block. All blocks will be performed under ultrasound guidance by an experienced anesthesiologist. Outcome assessments will be conducted by blinded investigators. The study aims to provide high-quality clinical evidence regarding the effectiveness of the BiFeS block compared to the widely used iPACK technique.
Eligibility Criteria
Inclusion Criteria: * Age 18-75 years * Scheduled for elective primary unilateral total knee arthroplasty (TKA) * Planned spinal anesthesia * ASA physical status I-III * Ability to understand study procedures and provide written informed consent Exclusion Criteria: * Known allergy or hypersensitivity to local anesthetics or other study medications * Coagulopathy or current anticoagulant therapy * Severe hepatic, renal, or cardiac failure * History of neuropathic pain * Infection at the site of proposed nerve block * Pre-existing neuromuscular disorders in the lower extremities * Inability to cooperate or refusal to participate in the study * Pregnancy
Contact & Investigator
Ahmet Murat Yayık, Principal Investigator
PRINCIPAL INVESTIGATOR
Ataturk University Department of Anesthesiology and Reanimation
Frequently Asked Questions
Who can join the NCT07248072 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Knee Osteoarthritis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07248072 currently recruiting?
Yes, NCT07248072 is actively recruiting participants. Contact the research team at m_yayik@hotmail.com for enrollment information.
Where is the NCT07248072 trial being conducted?
This trial is being conducted at Erzurum, Turkey (Türkiye).
Who is sponsoring the NCT07248072 clinical trial?
NCT07248072 is sponsored by Ataturk University. The principal investigator is Ahmet Murat Yayık, Principal Investigator at Ataturk University Department of Anesthesiology and Reanimation. The trial plans to enroll 74 participants.