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Medical Condition

knee osteoarthritis

Total Trials

25

Recruiting Now

25

Trial Phases

Phase 4, Phase 2, EARLY_Phase 1

ClinicalMetric tracks all active clinical trials for knee osteoarthritis sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — knee osteoarthritis Clinical Trials

How many clinical trials are currently recruiting for knee osteoarthritis?

ClinicalMetric currently tracks 25 actively recruiting clinical trials for knee osteoarthritis, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 25. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for knee osteoarthritis?

knee osteoarthritis research spans Phase 1 (1 trial), Phase 2 (2 trials), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a knee osteoarthritis clinical trial?

Eligibility criteria for knee osteoarthritis trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

1

Phase 2

2

Phase 4

1

Top Sponsors

Istituto Ortopedico Rizzoli 2 trials

McMaster University 2 trials

Assistance Publique - Hôpitaux de Paris 1 trial

Sunnybrook Health Sciences Centre 1 trial

Tian Hua 1 trial

Recruiting Clinical Trials

Clinical and Radiological Results of Long Term Tibial and Femoral Osteotomy in Knee Ostheoarthritis With Concomitant Lower Limb Malalignement

Istituto Ortopedico Rizzoli

IDENTIFICATION OF BIOMARKERS ASSOCIATED WITH THE SEVERITY AND RADIO-CLINICAL PROGRESSION OF KNEE OSTEOARTHRITIS

Assistance Publique - Hôpitaux...

NCT06423716 Phase 4

Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE)

Sunnybrook Health Sciences Cen...

Transcranial Direct Current Stimulation and Yoga for Knee Osteoarthritis

McMaster University

Clinical Cohort Study of Knee Arthroplasty Assisted by Digital Technology

Somatosensory Amplification and Psychological and Functional Status In Patients With Knee Osteoarthritis

Turkey (Türkiye)

Suleyman Demirel University

NCT05839535 Phase 2

Enhancing Modulation Effects of Baduanjin Through Neuromodulation for Knee OA

Massachusetts General Hospital

Survival Study of the Genutech® Total Knee Arthroplasty

Hospital de Sant Rafael

The Effects of Patient and Visit Characteristics on Health Outcomes in Knee Osteoarthritis

University of California, Davi...

Efficacy of Artificial Intelligence-Assisted Therapeutic Exercise in Patients With Knee Osteoarthritis

Universidad Complutense de Mad...

FAldini Sport Total Joint Arthroplasty-Knee II

Istituto Ortopedico Rizzoli

"Effectiveness of Mulligan Mobilization Technique and Proprioceptive Exercises Among Patients With Knee Osteoarthritis"

National Healthcare Center

NCT06906939 EARLY_Phase 1

A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression

University of California, Los ...

Remote Tai Chi for Knee Osteoarthritis

Tufts Medical Center

HILT Dose Optimization for Knee Osteoarthritis Pain

Al Hayah University In Cairo

Low-Level Laser Therapy in Knee Osteoarthritis: Effects on Clinical Outcomes, Femoral Cartilage Thickness and Regional Sarcopenia

Turkey (Türkiye)

Ankara Etlik City Hospital

NCT07547735 Phase 2

Phase II Clinical Trial of UC-MSCs in the Treatment of Knee Osteoarthritis

Union Hospital, Tongji Medical...

The ATtune Knee Outcome Study

Spaarne Gasthuis

Intraarticular Injection of Botox and Hyaluronic Acid in Knee Osteoarthritis

Tanta University

Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention

Tan Tock Seng Hospital

FitJoints: Getting Fit for Hip and Knee Replacement

McMaster University

Bowen Technique With Retro-walking on Hamstring Flexibility in Knee Osteoarthritis

Riphah International Universit...

Anatomical Axis on X-Ray and Its Relationship With Pain and Kinesiophobia in Knee Osteoarthritis

Turkey (Türkiye)

Total Knee Arthroplasty in Varus Deformity

I.M. Sechenov First Moscow Sta...

Effect of Sarcopenia on Clinical Outcome of Total Knee Arthroplasty

Gangnam Severance Hospital

Related Conditions

kinesiophobia (2) pain (2) malalignment bone (1) chronic inflammatory rheumatism (1) amplification (1) psychological disability (1) depression (1) low level laser therapy (1) regional sarcopenia (1) exercise theraphy (1) osteoarthritis knee (1) knee rheumatism (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology