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Medical Condition

knee osteoarthritis

Total Trials

25

Recruiting Now

25

Trial Phases

Phase 4, Phase 2, Phase 3

ClinicalMetric tracks all active clinical trials for knee osteoarthritis sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — knee osteoarthritis Clinical Trials

How many clinical trials are currently recruiting for knee osteoarthritis?

ClinicalMetric currently tracks 25 actively recruiting clinical trials for knee osteoarthritis, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 25. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for knee osteoarthritis?

knee osteoarthritis research spans Phase 2 (1 trial), Phase 3 (2 trials), Phase 4 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a knee osteoarthritis clinical trial?

Eligibility criteria for knee osteoarthritis trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 2

1

Phase 3

2

Phase 4

2

Top Sponsors

Northwestern University 1 trial

University of Chicago 1 trial

University of Portsmouth 1 trial

University of Miami 1 trial

King Abdulaziz University 1 trial

Recruiting Clinical Trials

NCT06245109 Phase 4

Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis

Northwestern University

NCT06859164 Phase 2

Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis

University of Chicago

Movement Dynamics of Knee Osteoarthritis and Total Knee Replacement

University of Portsmouth

NCT06902285 Phase 4

Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty

University of Miami

The Effect of Hybrid Tele-rehabilitation Versus In Person Rehabilitation on Pain and Function in Patients With Knee Osteoarthritis

King Abdulaziz University

Oral vs Intravenous Dexamethasone in Total Knee Arthroplasty

Turkey (Türkiye)

Haseki Training and Research H...

FDG PET/MRI Imaging of Patellofemoral Joint Osteoarthritis

University of California, San ...

Adapting Rehabilitation Delivery for Maximum Impact at Home-2 (ReDI-2)

University of Alberta

Robotic Assisted vs Custom Made Total Knee Arthroplasty

Austrian Workers Compensation ...

Long Term Evaluation of Clinical and Radiologic Results on Femoro-patellar Joint After High Tibial Osteotomy

Istituto Ortopedico Rizzoli

Intra-articular Corticosteroid Injection in GAE for Knee Knee Osteoarthritis

Zagazig University

NCT04318041 Phase 3

Evaluation of the Structural Modification Effect of Diacerein (Artrodar®) in Knee Osteoarthritic Patients

Evaluating the Efficacy of a Mobile Application in Postoperative Rehabilitation

Yale University

An Artificial Intelligence-based Approach in Total Knee Arthroplasty: From Inflammatory Responses to Personalized Medicine

Fondazione Policlinico Univers...

Patient Outcomes Following Kinematic and Functional Alignment in Robotic-Assisted Total Knee Arthroplasty With Randomized Insert Types

Singapore General Hospital

The Effect of Hyaluronic Acid Injection on TNF-Alpha and IL-1β in Knee Osteoarthritis

Turkey (Türkiye)

Istanbul University

Hip Abductor Strengthening Exercises in Knee Osteoarthritis

Riphah International Universit...

The Efficiency and Safety of PRP Treatment After Anterior Cruciate Ligament Reconstruction.

Nicolaus Copernicus University...

Focused Extracorporeal Shockwave Therapy for Knee Arthritis

Kessler Foundation

Diet Interventions: Remitted and Evaluated as Complementary Treatments for Pain

University of Alabama at Birmi...

NCT07219771 Phase 3

A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients

United States, Austr...

Doron Therapeutics Inc.

Knee Osteoarthritis and Spa Therapy

Genicular Artery Embolization vs Nerve Ablation Intervention (GENI) for Knee Osteoarthritis

Sonographic Thigh Adjustment Ratio and Subcutaneous Fat Thickness as Predictors of Genicular Nerve Block Response in Knee Osteoarthritis

Turkey (Türkiye)

Gaziosmanpasa Research and Edu...

Ischemic Preconditioning in Osteoarthritis and Back Pain

University of Illinois at Chic...

Related Conditions

knee osteoarthritis oa (2) knee osteoarthritis knee oa (1) total knee replacement (1) sleep (1) gonarthrosis primary (1) total knee arthroplasty (1) patellofemoral osteoarthritis (1) knee pain (1) inflamation (1) hip osteoarthritis (1) deformity knee (1) pain musculoskeletal (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology