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Medical Condition

knee osteoarthritis

Total Trials

27

Recruiting Now

27

Trial Phases

Phase 3, Phase 2, Phase 4

ClinicalMetric tracks all active clinical trials for knee osteoarthritis sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — knee osteoarthritis Clinical Trials

How many clinical trials are currently recruiting for knee osteoarthritis?

ClinicalMetric currently tracks 27 actively recruiting clinical trials for knee osteoarthritis, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 27. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for knee osteoarthritis?

knee osteoarthritis research spans Phase 2 (1 trial), Phase 3 (2 trials), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a knee osteoarthritis clinical trial?

Eligibility criteria for knee osteoarthritis trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 2

1

Phase 3

2

Phase 4

1

Top Sponsors

Kessler Foundation 1 trial

Yonsei University 1 trial

University of Arkansas 1 trial

Sohag University 1 trial

Pfizer 1 trial

Recruiting Clinical Trials

Focused Extracorporeal Shockwave Therapy for Knee Arthritis

Kessler Foundation

Comparison of Functional Recovery After Total Knee Arthroplasty Between Low Phase Angle and High Phase Angle Group

Yonsei University

Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing After Total Knee Arthroplasty (TKA)

University of Arkansas

Ultrasonographic Evaluation of Osteoarthritis.

Sohag University

NCT07915609 Phase 3

A Study to Learn About Berobenatide Given Once Weekly in Adults With Knee Osteoarthritis and Overweight or Obesity With or Without Type 2 Diabetes (VESPER-OA 2)

BioPoly® Partial Resurfacing Knee Implant IDE

NCT05839535 Phase 2

Enhancing Modulation Effects of Baduanjin Through Neuromodulation for Knee OA

Massachusetts General Hospital

Knee Ligament Stiffness Across Ethnicities Before and After Osteoarthritis Treatment

National Taiwan University Hos...

FitJoints: Getting Fit for Hip and Knee Replacement

McMaster University

Manual Arthroplasty Versus VELYS Robotic-Assisted Solution Functional Alignment Arthroplasty for Knee Osteoarthritis

Golden Jubilee National Hospit...

Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty

Turkey (Türkiye)

Balikesir Ataturk City Hospita...

Evaluation of Mobility in Subjects With Severe Knee Osteoarthritis Who Are to Undergo Total Knee Replacement

University Hospital, Montpelli...

NCT06570291 Phase 3

Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis

Wuxi Cellular Biopharmaceutica...

Unipolar Versus Bipolar Radiofrequency Ablation in Knee Osteoarthritis Pain

Tanta University

Effect of Physical Therapy Rehabilitation on Gait and Plantar Pressure in Patients After Total Knee Replacement

Jouf University

Effect of Remimazolam and Propofol on Postoperative Delirium

Inje University

Survival Study of the Genutech® Total Knee Arthroplasty

Hospital de Sant Rafael

Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an App

Technical University of Munich

Using ROSA for Challenging The TKA Standard of Care

London Health Sciences Centre ...

The Effects of Surgical Wait Time for Knee Arthroplasty Quality of Life in Patients Awaiting Knee Arthroplasty

Dijklander Ziekenhuis

A Multicenter, Postmarket Surveillance Study of Subjects With the Canary canturioTM te Tibial Extension

NCT06902285 Phase 4

Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty

University of Miami

A Comparative Study on the Safety and Efficacy of the Intra-Articular Injectable Filler ALLOHEAL in Patients With Knee Osteoarthritis

Endovision Co., Ltd.

Prospective Randomized Study Comparing the SpheriKA® (MEDACTA) and Origin® (SYMBIOS) Prostheses During Total Knee Replacement Using the Kinematic Alignment Technique

Clinique du Sport, Bordeaux Mé...

The ATtune Knee Outcome Study

Spaarne Gasthuis

Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty

Northwestern University

Bone Marrow Versus Adipose Tissue as a Cell Source for Infiltrative Treatment of Knee Osteoarthritis

Istituto Ortopedico Rizzoli

Related Conditions

knee pain chronic (2) hip osteoarthritis (2) osteoarthritis knee (2) bone marrow edema (1) obesity (1) overweight and or obesity (1) diabetes melliuts type 2 (1) cartilage damage (1) cartilage defects of the knee (1) cartilage or osteochondral defects in the knee (1) cartilage lesion (1) osteo arthritis of the knee (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology