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postoperative pain management

Total Trials
8
Recruiting Now
8
Trial Phases
Phase 4, Phase 3

Pain clinical trials span acute procedural pain, chronic musculoskeletal pain, neuropathic pain, and cancer-related pain β€” each requiring distinct trial designs and patient-reported outcome instruments. The regulatory demand for non-opioid alternatives has intensified the search for novel analgesic mechanisms, particularly ion channel targets and neurostimulation approaches.

Active trials evaluate Nav1.7/1.8 blockers, CGRP antagonists for new indications, spinal cord stimulation refinements, virtual reality-based pain management, and patient-specific ketamine infusion protocols. Pain trials increasingly use ecological momentary assessment (EMA) diary approaches over traditional recall-based pain rating scales.

Frequently Asked Questions — postoperative pain management Clinical Trials

How many clinical trials are currently recruiting for postoperative pain management?
ClinicalMetric currently tracks 8 actively recruiting clinical trials for postoperative pain management, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 8. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for postoperative pain management?
postoperative pain management research spans Phase 3 (1 trial), Phase 4 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a postoperative pain management clinical trial?
Eligibility criteria for postoperative pain management trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 3
1
Phase 4
1
Top Sponsors
Fondazione IRCCS Policlinico San Matteo di Pavia 1 trial
Hospital Universitario de Gran Canaria Doctor Negrín 1 trial
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University 1 trial
Alexander T. Yahanda 1 trial
Instituto Mexicano del Seguro Social 1 trial

Recruiting Clinical Trials

NCT07123805
Recruiting
ACU_Knee: Role of Acupuncture in Knee Prosthetic Surgery
Enrollment
80 pts
Location
Italy
Sponsor
Fondazione IRCCS Policlinico S...
View Trial →
NCT07694141
Recruiting
Postoperative Analgesia in Thoracic Surgery
Enrollment
160 pts
Location
Spain
Sponsor
Hospital Universitario de Gran...
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NCT07401641
Recruiting
Effect of Dezocine Versus Nalbuphine Combined With Sufentanil on Postoperative Analgesia, Complications, and Free Flap Survival in Patients Undergoing Oral Cancer Radical Surgery: A Randomized Controlled Clinical Trial.
Enrollment
60 pts
Location
China
Sponsor
Sun Yat-Sen Memorial Hospital ...
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NCT07218133
Recruiting
Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery
Enrollment
50 pts
Location
United States
Sponsor
Alexander T. Yahanda
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NCT07073846 Phase 4
Recruiting
Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery.
Enrollment
104 pts
Location
Mexico
Sponsor
Instituto Mexicano del Seguro ...
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NCT07394816
Recruiting
Can Ultrasound-Guided Fascial Plane Blocks Reduce Postoperative Pulmonary Complications After Major Abdominal Surgery?
Enrollment
500 pts
Location
Turkey (Türkiye)
Sponsor
Dr Abdurrahman Yurtaslan Ankar...
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NCT07113483 Phase 3
Recruiting
Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery
Enrollment
120 pts
Location
Romania
Sponsor
Romanian Society for Enteral a...
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NCT06964282
Recruiting
Iliopsoas (IPB) and Pericapsular Nerve Group (PENG) Blocks Comparison on Analgesia and Recovery After Total Hip Arthroplasty
Enrollment
118 pts
Location
Belgium
Sponsor
University of Liege
View Trial →

Related Conditions

acupuncture analgesia (1) acupuncture (1) acupuncture therapy (1) total knee anthroplasty (1) pain threshold (1) shoulder pain (1) laparoscopies (1) acupuncture ear (1) oral cancer (1) free tissue flaps (1) mouth neoplasms (1) spinal fusion (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology