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total knee arthroplasty

Total Trials
8
Recruiting Now
8
Trial Phases
Phase 2

ClinicalMetric tracks all active clinical trials for total knee arthroplasty sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — total knee arthroplasty Clinical Trials

How many clinical trials are currently recruiting for total knee arthroplasty?
ClinicalMetric currently tracks 8 actively recruiting clinical trials for total knee arthroplasty, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 8. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for total knee arthroplasty?
total knee arthroplasty research spans Phase 2 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a total knee arthroplasty clinical trial?
Eligibility criteria for total knee arthroplasty trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 2
1
Top Sponsors
University Hospital, Bonn 1 trial
Hitit University 1 trial
ScinnoHub Pharmaceutical Co., Ltd. 1 trial
Limacorporate S.p.a 1 trial
Social Medical Corporation Daiyukai 1 trial

Recruiting Clinical Trials

NCT06947655
Recruiting
Impact of Different Perioperative Tourniquets on Blood Loss and Surgeon Satisfaction in Total Knee Arthroplasty
Enrollment
50 pts
Location
Germany
Sponsor
University Hospital, Bonn
View Trial →
NCT07561333
Recruiting
Comparing ACB+IPACK and ACB+BiFeS Block Combinations for Analgesia in Total Knee Arthroplasty
Enrollment
78 pts
Location
Turkey (Türkiye)
Sponsor
Hitit University
View Trial →
NCT07127042 Phase 2
Recruiting
Study on BT-114143 Reducing Perioperative Bleeding in Total Knee Arthroplasty(TKA)
Enrollment
270 pts
Location
China
Sponsor
ScinnoHub Pharmaceutical Co., ...
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NCT05314491
Recruiting
Multigen Plus CCK and AMF TT Cones Follow Up Study
Enrollment
68 pts
Location
Portugal, Slovakia, ...
Sponsor
Limacorporate S.p.a
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NCT07524387
Recruiting
Femoral Triangle Block vs Adductor Canal Block on Early Quadriceps Function After Total Knee Arthroplasty
Enrollment
136 pts
Location
Japan
Sponsor
Social Medical Corporation Dai...
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NCT06328062
Recruiting
Comparing Efficiency of Mirogabalin and Pregabalin in Primary TKA
Enrollment
80 pts
Location
Thailand
Sponsor
Thammasat University Hospital
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NCT06124482
Recruiting
Performance and Safety Evaluation of the FHK®-CK Knee Prosthesis
Enrollment
92 pts
Location
France
Sponsor
FH ORTHO
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NCT06837844
Recruiting
Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty
Enrollment
75 pts
Location
Egypt
Sponsor
Kafrelsheikh University
View Trial →

Related Conditions

postoperative pain (1) revision total knee arthroplasty (1) total knee arthroplasty recovery (1) total knee arthroplasty postoperative pain (1) pain postoperative (1) osteoarthritis (1) intrathecal dexmedetomidine (1) adductor canal block (1) analgesia (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology