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total knee arthroplasty

Total Trials
7
Recruiting Now
7
Trial Phases
Various

ClinicalMetric tracks all active clinical trials for total knee arthroplasty sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — total knee arthroplasty Clinical Trials

How many clinical trials are currently recruiting for total knee arthroplasty?
ClinicalMetric currently tracks 7 actively recruiting clinical trials for total knee arthroplasty, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 7. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for total knee arthroplasty?
total knee arthroplasty research spans multiple clinical trial phases. Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a total knee arthroplasty clinical trial?
Eligibility criteria for total knee arthroplasty trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Top Sponsors
Kafrelsheikh University 1 trial
FH ORTHO 1 trial
Inonu University 1 trial
University of Miami 1 trial
Medacta International SA 1 trial

Recruiting Clinical Trials

NCT06837844
Recruiting
Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty
Enrollment
75 pts
Location
Egypt
Sponsor
Kafrelsheikh University
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NCT06124482
Recruiting
Performance and Safety Evaluation of the FHK®-CK Knee Prosthesis
Enrollment
92 pts
Location
France
Sponsor
FH ORTHO
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NCT07885449
Recruiting
The Effect of Mind Mapping-Based Education on Postoperative Pain, Kinesiophobia, and Discharge Readiness in Patients Undergoing Total Knee Arthroplasty
Enrollment
102 pts
Location
Turkey (Türkiye)
Sponsor
Inonu University
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NCT07437469
Recruiting
Binaural Beats for Postoperative Pain and Anxiety Reduction
Enrollment
50 pts
Location
United States
Sponsor
University of Miami
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NCT04801654
Recruiting
GMK Sphere TiNb Total Knee Arthroplasty PMS Study
Enrollment
155 pts
Location
Italy
Sponsor
Medacta International SA
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NCT06929871
Recruiting
Mako Cementless TKA vs Mako Cemented TKA
Enrollment
120 pts
Location
United Kingdom
Sponsor
University College, London
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NCT06947655
Recruiting
Impact of Different Perioperative Tourniquets on Blood Loss and Surgeon Satisfaction in Total Knee Arthroplasty
Enrollment
50 pts
Location
Germany
Sponsor
University Hospital, Bonn
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Related Conditions

total knee replacement (2) intrathecal dexmedetomidine (1) adductor canal block (1) analgesia (1) tka (1) tha (1) anxiety (1) binaural beats (1) music exposure (1) total hip arthroplasty tha (1) total hip replacement (1) total knee replacement surgery (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology