State TN
Clinical Trials in Tennessee
Tennessee is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Tennessee and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 296 actively recruiting studies with Tennessee sites out of 296 registered in total. The busiest research areas in Tennessee are Breast Cancer, Heart Failure, Colorectal Cancer. Leading sponsors running trials in the state include Vanderbilt University Medical Center, St. Jude Children's Research Hospital, Merck Sharp & Dohme LLC. By stage, Tennessee trials break down as Phase 1 (74), Phase 2 (76), Phase 3 (70), Phase 4 (6).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Tennessee
Frequently Asked Questions — Clinical Trials in Tennessee
How many clinical trials are currently recruiting in Tennessee?
ClinicalMetric currently tracks 296 actively recruiting clinical trials with at least one location in Tennessee. The total number of registered studies—including active but not currently enrolling trials—is 296. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Tennessee?
Tennessee hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Heart Failure, Colorectal Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Tennessee serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Tennessee?
To join a clinical trial in Tennessee, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Tennessee maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Tennessee
NCT06625073 Phase 4
Recruiting
Randomized Trial of SGLT2i in Heart Transplant Recipients
Condition
Heart Transplant
Enrollment
200 pts
Location
United States
Sponsor
VA Office of Research and Deve
NCT04802759 Phase 1, Phase 2
Recruiting
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in...
Condition
Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer
Enrollment
316 pts
Location
United States, Australia, Israel
Sponsor
Hoffmann-La Roche
NCT06498635 Phase 3
Recruiting
Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After ...
Condition
Lung Non-Small Cell Carcinoma
Enrollment
306 pts
Location
United States
Sponsor
National Cancer Institute (NCI
NCT07111663 N/A
Recruiting
An Observational Study of Individuals With Isolated Dystonia
Condition
Isolated/Primary Dystonia That Affects More Than One Region of the Body
Enrollment
200 pts
Location
United States
Sponsor
Vima Therapeutics
NCT07244211 N/A
Recruiting
MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recove...
Condition
Femoral Neck Fractures
Enrollment
600 pts
Location
United States, Canada, Norway
Sponsor
University of Southern Califor
NCT07220811 Phase 2
Recruiting
Phase 2b Study of RPT904 as Monotherapy in Participants With IgE-Mediated Food A...
Condition
Ig-E Mediated Food Allergy
Enrollment
100 pts
Location
United States, Australia, Canada
Sponsor
RAPT Therapeutics, Inc.
NCT07680764 Phase 2
Recruiting
A Study To Assess the Safety, Tolerability, and Efficacy of Imzokitug in Combina...
Condition
Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
Enrollment
160 pts
Location
United States, Argentina, Australia
Sponsor
Bristol-Myers Squibb
NCT07207811 Phase 3
Recruiting
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine...
Condition
Transthyretin Amyloid Cardiomyopathy (ATTR CM)
Enrollment
1,280 pts
Location
United States, Argentina, Australia
Sponsor
Novo Nordisk A/S
NCT05748834 Phase 2
Recruiting
Study of Tucatinib and Doxil in Participants With Human Epidermal Growth Factor ...
Condition
Breast Cancer
Enrollment
36 pts
Location
United States
Sponsor
SCRI Development Innovations,
NCT05780034 Phase 1
Recruiting
A Study of AC676 for the Treatment of Relapsed/Refractory B-Cell Malignancies
Condition
Relapsed/Refractory B-cell Malignancies
Enrollment
60 pts
Location
United States
Sponsor
Accutar Biotechnology Inc
NCT06415487 Phase 1
Recruiting
ACE2016 in Adult Subjects With Locally Advanced or Metastatic Solid Tumors Expre...
Condition
Locally Advanced Solid Tumor
Enrollment
30 pts
Location
United States, Taiwan
Sponsor
Acepodia Biotech, Inc.
NCT05735184 Phase 1
Recruiting
A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination ...
Condition
Acute Myeloid Leukemia
Enrollment
420 pts
Location
United States
Sponsor
Kura Oncology, Inc.
NCT06526052 N/A
Recruiting
A Randomized Controlled Trial Testing the Effect of the Youth Mindful Awareness ...
Condition
Prevention
Enrollment
360 pts
Location
United States
Sponsor
Vanderbilt University
NCT07145411 N/A
Recruiting
HPC Offered for PRESERVE Expansion
Condition
Bone Marrow Transplant (BMT)
Enrollment
10 pts
Location
United States
Sponsor
Ossium Health, Inc.
NCT05877599 Phase 1
Recruiting
A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Posi...
Condition
Non-small Cell Lung Cancer
Enrollment
45 pts
Location
United States
Sponsor
AstraZeneca
NCT06623422 Phase 3
Recruiting
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in...
Condition
Carcinoma, Non-Small-Cell Lung
Enrollment
680 pts
Location
United States, Argentina, Australia
Sponsor
Merck Sharp & Dohme LLC
NCT00899301 N/A
Recruiting
Collecting and Storing Tissue Samples From Women With or Without Breast Cancer
Condition
Breast Cancer
Enrollment
4,000 pts
Location
United States
Sponsor
Vanderbilt-Ingram Cancer Cente
NCT06680830 Phase 2
Recruiting
A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Posi...
Condition
Parkinson Disease
Enrollment
150 pts
Location
United States, Israel, Italy
Sponsor
Neuron23 Inc.
NCT07225751 N/A
Recruiting
A Prospective, Randomized, Single-blind, Controlled, Multi-center Study to Asses...
Condition
Ankle Arthrodesis or Arthroplasty
Enrollment
126 pts
Location
United States
Sponsor
Kuros Biosurgery AG
NCT06455995 N/A
Recruiting
Daily Eating Patterns for Total Health Study
Condition
Obesity
Enrollment
174 pts
Location
United States
Sponsor
The University of Tennessee, K
NCT07287995 Phase 1, Phase 2
Recruiting
A Study of ASP2998 Given by Itself and Given With Standard Therapies in People W...
Condition
Locally Advanced or Metastatic Malignant Solid Tumors
Enrollment
428 pts
Location
United States, Japan
Sponsor
Astellas Pharma Global Develop
NCT05401357 Phase 3
Recruiting
Bioequivalence Study With Clinical Endpoint Comparing Bimatoprost Ophthalmic Sol...
Condition
Glaucoma, Open-Angle
Enrollment
168 pts
Location
United States
Sponsor
Amneal Pharmaceuticals, LLC
NCT07028853 Phase 3
Recruiting
This Study Will Explore Whether a Combination of the Investigational Drug Mevrom...
Condition
Metastatic Castration Sensitive Prostate Cancer (mCSPC)
Enrollment
1,000 pts
Location
United States, Argentina, Australia
Sponsor
Pfizer
NCT07059845 Phase 2
Recruiting
A Study to Assess Adverse Events and Change in Disease Activity of Multiple Trea...
Condition
Ovarian Cancer
Enrollment
400 pts
Location
United States, Australia, Belgium
Sponsor
AbbVie
NCT07012395 Phase 2
Recruiting
A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Seve...
Condition
Ulcerative Colitis
Enrollment
645 pts
Location
United States, Argentina, Australia
Sponsor
Spyre Therapeutics, Inc.
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology