State TN
Clinical Trials in Tennessee
Tennessee is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Tennessee and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 312 actively recruiting studies with Tennessee sites out of 312 registered in total. The busiest research areas in Tennessee are Breast Cancer, Endometrial Cancer, Advanced Solid Tumors. Leading sponsors running trials in the state include Vanderbilt University Medical Center, St. Jude Children's Research Hospital, AstraZeneca. By stage, Tennessee trials break down as Phase 1 (80), Phase 2 (93), Phase 3 (93), Phase 4 (12).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Tennessee
Frequently Asked Questions — Clinical Trials in Tennessee
How many clinical trials are currently recruiting in Tennessee?
ClinicalMetric currently tracks 312 actively recruiting clinical trials with at least one location in Tennessee. The total number of registered studies—including active but not currently enrolling trials—is 312. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Tennessee?
Tennessee hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Endometrial Cancer, Advanced Solid Tumors, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Tennessee serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Tennessee?
To join a clinical trial in Tennessee, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Tennessee maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Tennessee
NCT07165028 Phase 3
Recruiting
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associ...
Condition
Metabolic Dysfunction-Associated Steatotic Liver Disease
Enrollment
4,500 pts
Location
United States, Argentina, Australia
Sponsor
Eli Lilly and Company
NCT05762107 Phase 2
Recruiting
A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes
Condition
Type 1 Diabetes Mellitus With Hypoglycemia
Enrollment
186 pts
Location
United States, Canada
Sponsor
Zucara Therapeutics Inc.
NCT04176198 Phase 1, Phase 2
Recruiting
A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis
Condition
Myelofibrosis
Enrollment
240 pts
Location
United States, Australia, Belgium
Sponsor
Sumitomo Pharma America, Inc.
NCT07288398 Phase 3
Recruiting
LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
Condition
Pulmonary Hypertension Associated With HFpEF
Enrollment
540 pts
Location
United States, Argentina, Austria
Sponsor
Tenax Therapeutics, Inc.
NCT00009633 N/A
Recruiting
Follow-up Visit of High Risk Infants
Condition
Infant, Newborn
Enrollment
68,000 pts
Location
United States
Sponsor
NICHD Neonatal Research Networ
NCT06059638 N/A
Recruiting
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
Condition
Hypertension
Enrollment
316 pts
Location
United States, Australia, Belgium
Sponsor
Orchestra BioMed, Inc
NCT05664113 Phase 1
Recruiting
Feasibility, Safety, and Potential Efficacy of Fecal Microbiota Transplantation ...
Condition
Gastro-Intestinal Disorder
Enrollment
10 pts
Location
United States
Sponsor
St. Jude Children's Research H
NCT06393374 Phase 3
Recruiting
Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did ...
Condition
Triple-Negative Breast Cancer
Enrollment
1,530 pts
Location
United States, Argentina, Australia
Sponsor
Merck Sharp & Dohme LLC
NCT06701214 N/A
Recruiting
The Clonal Hematopoiesis & Inflammation in Vasculature Registry and Biorepositor...
Condition
Clonal Hematopoiesis
Enrollment
800 pts
Location
United States
Sponsor
Vanderbilt-Ingram Cancer Cente
NCT01524276 N/A
Recruiting
Product Surveillance Registry
Condition
Cardiac Rhythm Disorders
Enrollment
100,000 pts
Location
United States, Argentina, Australia
Sponsor
Medtronic
NCT07218926 Phase 3
Recruiting
A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastr...
Condition
Gastrointestinal Neoplasms
Enrollment
450 pts
Location
United States, Australia, Belgium
Sponsor
GlaxoSmithKline
NCT06095089 Phase 1
Recruiting
A Study of JNJ-87189401 Combined With JNJ-78278343 for Advanced Prostate Cancer
Condition
Prostatic Neoplasms
Enrollment
355 pts
Location
United States, Australia, China
Sponsor
Janssen Research & Development
NCT07705035 Phase 1
Recruiting
DBC-664 in Adult Patients With Solid Tumors
Condition
Malignant Germ Cell Tumor
Enrollment
210 pts
Location
United States
Sponsor
Duboce Biopharmaceuticals, Inc
NCT06613360 Phase 1
Recruiting
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, ...
Condition
SLE
Enrollment
24 pts
Location
United States, Australia, Bulgaria
Sponsor
Cullinan Therapeutics Inc.
NCT06619561 Phase 2
Recruiting
A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host ...
Condition
Chronic Graft-Versus-Host Disease (cGVHD)
Enrollment
48 pts
Location
United States
Sponsor
Deciphera Pharmaceuticals, LLC
NCT05920356 Phase 3
Recruiting
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab P...
Condition
Non-Small Cell Lung Cancer (NSCLC)
Enrollment
750 pts
Location
United States, Argentina, Australia
Sponsor
Amgen
NCT07489066 Phase 2
Recruiting
Symbiotic-Lung-10: A Study to Learn About PF-08634404 Alone or in Combination in...
Condition
Carcinoma
Enrollment
120 pts
Location
United States, China, Israel
Sponsor
Pfizer
NCT07385651 N/A
Recruiting
Deceased Donor Kidney Storage at 10 Celsius Versus Conventional Storage
Condition
End Stage Chronic Renal Failure
Enrollment
30 pts
Location
United States
Sponsor
Vanderbilt University Medical
NCT06667141 Phase 1
Recruiting
Phase 1 Study of ACR-2316 in Specific Advanced Solid Tumors
Condition
Specific Advanced Solid Tumors
Enrollment
100 pts
Location
United States
Sponsor
Acrivon Therapeutics
NCT06152575 Phase 3
Recruiting
MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in P...
Condition
Multiple Myeloma
Enrollment
492 pts
Location
United States, Argentina, Australia
Sponsor
Pfizer
NCT06324357 Phase 1, Phase 2
Recruiting
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in...
Condition
Metastatic Breast Cancer
Enrollment
768 pts
Location
United States, Belgium, China
Sponsor
Boehringer Ingelheim
NCT06526819 Phase 1, Phase 2
Recruiting
SMP-3124LP in Adults With Advanced Solid Tumors
Condition
Solid Tumor
Enrollment
120 pts
Location
United States, Japan
Sponsor
Sumitomo Pharma America, Inc.
NCT07717892 Phase 3
Recruiting
Forward Treatment of Attention Deficit and Hyperactivity Using Solriamfetol (FOC...
Condition
ADHD
Enrollment
468 pts
Location
United States
Sponsor
Axsome Therapeutics, Inc.
NCT07585266 Phase 3
Recruiting
A Study to Investigate Velzatinib Compared With Imatinib in Adult Participants W...
Condition
Gastrointestinal Stromal Neoplasms
Enrollment
800 pts
Location
United States, Argentina, Canada
Sponsor
GlaxoSmithKline
NCT06190171 N/A
Recruiting
Respiratory Strength Training in Heart Transplant Recipients
Condition
Dysphagia
Enrollment
90 pts
Location
United States
Sponsor
Vanderbilt University Medical
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology