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Clinical Trials in South Dakota

South Dakota is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in South Dakota and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.

Right now ClinicalMetric tracks 59 actively recruiting studies with South Dakota sites out of 59 registered in total. The busiest research areas in South Dakota are Breast Cancer, Endometrial Cancer, Metastatic Breast Cancer. Leading sponsors running trials in the state include National Cancer Institute (NCI), NRG Oncology, Alliance for Clinical Trials in Oncology. By stage, South Dakota trials break down as Phase 1 (5), Phase 2 (17), Phase 3 (27).

All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.

Total Trials
59
Recruiting Now
59
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Top Conditions in South Dakota
Breast Cancer (5)Endometrial Cancer (4)Metastatic Breast Cancer (2)Esophageal Adenocarcinoma (2)Gastroesophageal Junction Adenocarcinoma (2)Ovarian Cancer (2)Fallopian Tube Cancer (2)Lung Non-Small Cell Carcinoma (2)PIK3CA Mutation (1)HER2- Negative Breast Cancer (1)Hormone Receptor Positive Tumor (1)Advanced Breast Cancer (1)

Frequently Asked Questions — Clinical Trials in South Dakota

How many clinical trials are currently recruiting in South Dakota?
ClinicalMetric currently tracks 59 actively recruiting clinical trials with at least one location in South Dakota. The total number of registered studies—including active but not currently enrolling trials—is 59. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in South Dakota?
South Dakota hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Endometrial Cancer, Metastatic Breast Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout South Dakota serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in South Dakota?
To join a clinical trial in South Dakota, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in South Dakota maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.

Recruiting Trials in South Dakota

NCT04804644 Phase 3
Recruiting
Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Who...
Condition
Metastatic Lung Small Cell Carcinoma
Enrollment
200 pts
Location
United States, Canada
Sponsor
NRG Oncology
View Trial →
NCT07405801 Phase 2
Recruiting
A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribocicli...
Condition
Breast Cancer
Enrollment
80 pts
Location
United States, Argentina, Brazil
Sponsor
Hoffmann-La Roche
View Trial →
NCT07022483 Phase 3
Recruiting
Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Ex...
Condition
Endometrial Cancer
Enrollment
710 pts
Location
United States, Argentina, China
Sponsor
Daiichi Sankyo
View Trial →
NCT04267848 Phase 3
Recruiting
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemoth...
Condition
Lung Non-Small Cell Carcinoma
Enrollment
1,210 pts
Location
United States, Guam
Sponsor
National Cancer Institute (NCI
View Trial →
NCT06425848 N/A
Recruiting
HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry
Condition
Heart Failure
Enrollment
2,000 pts
Location
United States
Sponsor
University of Kansas Medical C
View Trial →
NCT06492616 Phase 3
Recruiting
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With E...
Condition
Breast Cancer
Enrollment
4,220 pts
Location
United States, Argentina, Australia
Sponsor
Stemline Therapeutics, Inc.
View Trial →
NCT07214532 N/A
Recruiting
Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
Condition
Breast Neoplasms
Enrollment
725 pts
Location
United States
Sponsor
Natera, Inc.
View Trial →
NCT06876714 Phase 3
Recruiting
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People W...
Condition
Anatomic Stage I Breast Cancer AJCC v8
Enrollment
1,524 pts
Location
United States, Puerto Rico
Sponsor
Alliance for Clinical Trials i
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NCT03851445 Phase 2, Phase 3
Recruiting
Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung...
Condition
Previously Treated Non-Small Cell Lung Cancer
Enrollment
10,000 pts
Location
United States
Sponsor
SWOG Cancer Research Network
View Trial →
Page 3 of 3 — 59 trials total
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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology