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Clinical Trials in South Dakota

South Dakota is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in South Dakota and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.

All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.

Total Trials

48

Recruiting Now

48

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Top Conditions in South Dakota

Breast Cancer (2)Stage IIIB Lung Cancer AJCC v8 (2)Leiomyosarcoma (2)Stage IV Lung Cancer AJCC v8 (2)Ovarian Cancer (2)Acute Myeloid Leukemia (1)Abdominal Aortic Aneurysm (1)Heart Failure (1)Chronic Obstructive Pulmonary Disease (COPD) (1)Childhood Medulloblastoma (1)Moderately to Severely Active Crohn Disease (1)Colorectal Cancer (1)

Frequently Asked Questions — Clinical Trials in South Dakota

How many clinical trials are currently recruiting in South Dakota?

ClinicalMetric currently tracks 48 actively recruiting clinical trials with at least one location in South Dakota. The total number of registered studies—including active but not currently enrolling trials—is 48. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.

What types of clinical trials are available in South Dakota?

South Dakota hosts clinical trials across a broad range of medical conditions, including Breast Cancer, Stage IIIB Lung Cancer AJCC v8, Leiomyosarcoma, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout South Dakota serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.

How do I join a clinical trial near me in South Dakota?

To join a clinical trial in South Dakota, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in South Dakota maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.

Recruiting Trials in South Dakota

NCT04293562 Phase 3

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilterit...

Acute Myeloid Leukemia

United States, Australia, Canada

Children's Oncology Group

NCT06001918 Phase 2, Phase 3

Nectero EAST System Clinical Study

Abdominal Aortic Aneurysm

United States, Australia, New Zealand

Nectero Medical, Inc.

NCT05636176 Phase 3

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People...

United States, Argentina, Australia

Novo Nordisk A/S

NCT07082738 Phase 2

A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Ve...

Chronic Obstructive Pulmonary Disease (COPD)

United States, Argentina, Australia

NCT05382338 Phase 3

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hear...

Childhood Medulloblastoma

United States, Canada

Children's Oncology Group

NCT06456593 Phase 2

Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active...

Moderately to Severely Active Crohn Disease

United States, Belgium, Czechia

NCT03998202 N/A

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal...

Colorectal Cancer

Wake Forest University Health

NCT01804686 Phase 3

A Long-term Extension Study of PCI-32765 (Ibrutinib)

Chronic Lymphocytic Leukemia

United States, Argentina, Australia

Janssen Research & Development

NCT05076942 Phase 2

Groningen International Study on Sentinel Nodes in Vulvar Cancer-III

United States, Netherlands

University Medical Center Gron

NCT07227597 Phase 1, Phase 2

A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in ...

Small Cell Lung Cancer Extensive Stage

United States, Argentina, Chile

Merck Sharp & Dohme LLC

NCT07144761 N/A

Evaluating Patient Reported Outcomes and Surgeon Satisfaction With Ziplyft™

NCT05624450 Phase 3

Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infec...

Viral Lung Infection and Acute Respiratory Failure

United States, Argentina, Australia

NCT06989359 Phase 2

Phase 2 Study of ADX-038 in Complement-Mediated Kidney Disease

United States, Australia, Hong Kong

ADARx Pharmaceuticals, Inc.

NCT06982521 Phase 3

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatme...

PIK3CA Mutation

United States, Argentina, Australia

Relay Therapeutics, Inc.

NCT05128825 Phase 2

A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Se...

High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

United States, Australia, Belgium

K-Group, Beta, Inc., a wholly

NCT06498635 Phase 3

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After ...

Lung Non-Small Cell Carcinoma

National Cancer Institute (NCI

NCT01793168 N/A

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Dis...

United States, Australia

NCT07223840 Phase 2

A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid R...

United States, China, Japan

Eli Lilly and Company

NCT06283966 Phase 3

A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fum...

COPD (Chronic Obstructive Pulmonary Disease)

United States, Argentina, Australia

NCT06500455 Phase 3

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in ...

Anatomic Stage IV Breast Cancer AJCC v8

United States, Canada, Hong Kong

NCT07089875 Phase 3

A Study of Dotinurad Versus Allopurinol in Participants With Gout

United States, Poland, Spain

Crystalys Therapeutics

NCT07493512 Phase 1

Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Can...

Metastatic Castration-resistant Prostate Cancer (mCRPC)

NCT06527157 N/A

Investigations of Reproductive Cancers in Women

NCT05828069 Phase 2

A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapse...

Recurrent Langerhans Cell Histiocytosis

United States, Australia, Canada

National Cancer Institute (NCI

NCT06767462 N/A

An Ophthalmic Safety Study in Patients With Breast Cancer

Ophthalmic Safety in Patients With Breast Cancer

United States, Argentina, Belgium

Page 1 of 2 — 48 trials total

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology