State IL
Clinical Trials in Illinois
Illinois is home to a significant concentration of clinical research activity, with academic medical centers, community hospitals, and specialized research clinics serving as active trial sites across a broad range of medical conditions. The studies listed here have at least one enrolled site in Illinois and represent Phase 1 through Phase 4 research sponsored by NIH, pharmaceutical companies, device manufacturers, and independent investigators.
Right now ClinicalMetric tracks 406 actively recruiting studies with Illinois sites out of 406 registered in total. The busiest research areas in Illinois are Ovarian Cancer, Breast Cancer, Prostate Cancer. Leading sponsors running trials in the state include University of Chicago, Northwestern University, National Cancer Institute (NCI). By stage, Illinois trials break down as Phase 1 (66), Phase 2 (130), Phase 3 (103), Phase 4 (13).
All trial data is sourced directly from ClinicalTrials.gov and updated daily. Recruiting status, eligibility criteria, enrollment targets, and contact information are included for each study. Patients and caregivers should review the full eligibility criteria on each trial listing — or consult their treating physician — before contacting a study site.
Top Conditions in Illinois
Frequently Asked Questions — Clinical Trials in Illinois
How many clinical trials are currently recruiting in Illinois?
ClinicalMetric currently tracks 406 actively recruiting clinical trials with at least one location in Illinois. The total number of registered studies—including active but not currently enrolling trials—is 406. Trial availability is updated daily from ClinicalTrials.gov, and new studies open enrollment regularly throughout the year.
What types of clinical trials are available in Illinois?
Illinois hosts clinical trials across a broad range of medical conditions, including Ovarian Cancer, Breast Cancer, Prostate Cancer, and many others. Trials range from Phase 1 early-safety studies to Phase 4 post-approval surveillance, as well as observational and behavioral research. Academic medical centers, community hospitals, and specialized research clinics throughout Illinois serve as trial sites for studies sponsored by NIH, pharmaceutical companies, and independent investigators.
How do I join a clinical trial near me in Illinois?
To join a clinical trial in Illinois, browse the recruiting studies listed on this page, review the eligibility criteria for each trial, and contact the study site directly. Your primary care physician or specialist can also refer you to clinical trials relevant to your diagnosis. Many academic medical centers in Illinois maintain dedicated clinical trials offices that can match you with appropriate studies based on your medical profile and diagnosis.
Recruiting Trials in Illinois
NCT05745285 N/A
Recruiting
Leukemia and Lymphoma Society (LLS) Services Impact on Outcomes and Care
Condition
Leukemia
Enrollment
400 pts
Location
United States
Sponsor
University of Miami
NCT06790693 Phase 3
Recruiting
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor a...
Condition
Breast Cancer
Enrollment
450 pts
Location
United States, Argentina, Australia
Sponsor
Hoffmann-La Roche
NCT07713849 N/A
Recruiting
Transition Care for FEP
Condition
Schizoaffective Disorders
Enrollment
75 pts
Location
United States
Sponsor
University of Chicago
NCT06030063 N/A
Recruiting
The Society for Obstetric Anesthesia and Perinatology Research Network General A...
Condition
Cesarean Delivery
Enrollment
5,000 pts
Location
United States, Canada
Sponsor
Yale University
NCT07295847 Phase 1, Phase 2
Recruiting
A Study of AZD0120 in Autoimmune Diseases
Condition
Systemic Sclerosis
Enrollment
27 pts
Location
United States, Australia, Germany
Sponsor
AstraZeneca
NCT05561387 Phase 3
Recruiting
Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM)...
Condition
Plasma Cell Myeloma
Enrollment
510 pts
Location
United States
Sponsor
SWOG Cancer Research Network
NCT06532006 Phase 3
Recruiting
A Phase Ⅲ Clinical Study of HLX22 in Combination With Trastuzumab and Chemothera...
Condition
Gastroesophageal-junction Cancer
Enrollment
550 pts
Location
United States, Argentina, Australia
Sponsor
Shanghai Henlius Biotech
NCT07737743 Phase 2
Recruiting
A Phase 2a/b Study to Assess the Efficacy, Safety and Tolerability of DDY391 in ...
Condition
Sjögren's Disease
Enrollment
344 pts
Location
United States, Australia, Canada
Sponsor
Novartis Pharmaceuticals
NCT05455619 Phase 1, Phase 2
Recruiting
Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K A...
Condition
HR+/HER2-negative Breast Cancer
Enrollment
52 pts
Location
United States
Sponsor
SynDevRx, Inc.
NCT06330064 Phase 1, Phase 2
Recruiting
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in ...
Condition
Recurrent or Metastatic Solid Tumors
Enrollment
680 pts
Location
United States, Argentina, Australia
Sponsor
Daiichi Sankyo
NCT07518186 Phase 3
Recruiting
A Study Comparing JNJ-79635322 and Teclistamab in Participants With Relapsed or ...
Condition
Multiple Myeloma
Enrollment
700 pts
Location
United States, Australia, Brazil
Sponsor
Janssen Research & Development
NCT05417594 Phase 1, Phase 2
Recruiting
Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Pa...
Condition
Advanced Solid Malignancies
Enrollment
695 pts
Location
United States, Australia, Germany
Sponsor
AstraZeneca
NCT03406611 Phase 1, Phase 2
Recruiting
Pegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (A...
Condition
Homocystinuria
Enrollment
39 pts
Location
United States, France, Qatar
Sponsor
Travere Therapeutics, Inc.
NCT07296744 N/A
Recruiting
Pivotal Study of the SUpira System in Patients Undergoing High-Risk Percutaneous...
Condition
Coronary Artery Disease
Enrollment
358 pts
Location
United States
Sponsor
Supira Medical
NCT07062471 N/A
Recruiting
Study of the Shockwave Medical SkyRunner Carotid Intravascular Lithotripsy (IVL)...
Condition
Carotid Artery Calcification
Enrollment
185 pts
Location
United States
Sponsor
Shockwave Medical, Inc.
NCT05234567 N/A
Recruiting
A Prospective Sub-Study of the Global Hypophosphatasia Registry
Condition
Hypophosphatasia
Enrollment
30 pts
Location
United States
Sponsor
Alexion Pharmaceuticals, Inc.
NCT04825587 N/A
Recruiting
The Pediatric ALL Evaluation and Trial
Condition
ACL Injury
Enrollment
240 pts
Location
United States
Sponsor
Ann & Robert H Lurie Children'
NCT06825819 N/A
Recruiting
Dysbiosis & Long COVID
Condition
COVID-19
Enrollment
400 pts
Location
United States
Sponsor
University of Chicago
NCT07612267 Phase 4
Recruiting
A Study to Measure Mirikizumab Levels in Breast Milk of Lactating Participants R...
Condition
Lactation
Enrollment
14 pts
Location
United States, Canada, Denmark
Sponsor
Eli Lilly and Company
NCT03708900 Phase 2
Recruiting
Pharmacokinetic (PK), Pharmacodynamic (PD) and Tolerability of Osilodrostat in P...
Condition
Cushing Syndrome
Enrollment
12 pts
Location
United States, Belgium, Bulgaria
Sponsor
RECORDATI GROUP
NCT05029999 Phase 1
Recruiting
CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer
Condition
HER2-negative Breast Cancer
Enrollment
30 pts
Location
United States
Sponsor
University of Texas Southweste
NCT07065630 Phase 2
Recruiting
Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck...
Condition
Head and Neck Cancer
Enrollment
38 pts
Location
United States
Sponsor
University of Chicago
NCT06603844 Phase 1, Phase 2
Recruiting
First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.
Condition
Solid Tumor
Enrollment
156 pts
Location
United States, United Kingdom
Sponsor
Corbus Pharmaceuticals Inc.
NCT07485036 N/A
Recruiting
Maternal Outcomes: Mood, Alcohol Use, and Depressive Symptoms
Condition
Postpartum Depression (PPD)
Enrollment
30 pts
Location
United States
Sponsor
University of Illinois Chicago
NCT06997497 Phase 3
Recruiting
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy ...
Condition
Colon Adenocarcinoma
Enrollment
477 pts
Location
United States, Argentina, Australia
Sponsor
Merck Sharp & Dohme LLC
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology