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Sanofi

Total Trials
9
Recruiting
9
Phases
Phase 2, Phase 3

Sanofi is a French multinational pharmaceutical company and one of the world's five largest by revenue, with a global clinical development operation spanning immunology, oncology, rare diseases and blood disorders, vaccines, and consumer healthcare. Sanofi has a long legacy in diabetes (insulin glargine/Lantus was the world's best-selling insulin for over a decade), cardiovascular disease (alirocumab/Praluent for LDL reduction), and multiple sclerosis (teriflunomide/Aubagio, alemtuzumab/Lemtrada).

Sanofi's research transformation in recent years has concentrated investment heavily on immunology and inflammation — particularly the dupilumab program co-developed with Regeneron — and on rare blood disorders and oncology. In oncology, cemiplimab (Libtayo), a PD-1 inhibitor, is a key asset with multiple active indications. Sanofi acquired Translate Bio (mRNA technology) and Kadmon (itepekimab for COPD and pediatric asthma) and has early programs in mRNA therapeutics for cancer and infectious disease. The Rare Diseases unit — historically Genzyme — is a global leader in enzyme replacement therapy for lysosomal storage disorders.

Sanofi Pasteur, the company's vaccine division, is one of the world's largest vaccine producers, with approved vaccines for influenza, dengue, meningococcal disease, typhoid, rabies, and others, and active clinical trials in RSV, mRNA influenza, and pandemic preparedness. Sanofi conducts clinical research through partnerships with NIH, BARDA, CEPI, and academic institutions globally, and runs one of the most active Phase 3 trial programs in the rare disease space.

Frequently Asked Questions — Sanofi

What rare disease trials does Sanofi's Genzyme division sponsor?
Sanofi Genzyme, acquired in 2011, is the rare disease and specialty care unit. Genzyme pioneered enzyme replacement therapy (ERT) for lysosomal storage disorders and continues to run active trials in Gaucher disease (eliglustat, new formulations), Fabry disease (migalastat, pegunigalsidase alfa), Pompe disease (avalglucosidase alfa and next-generation ERTs), and mucopolysaccharidoses. Beyond enzyme replacement, Genzyme has programs in multiple sclerosis, PKD (polycystic kidney disease), and rare neurological conditions. The Genzyme rare disease research network spans centers across North America, Europe, and Latin America, with many trials enrolling patients in pediatric hospitals and metabolic disease centers.
What immunology conditions does Sanofi study in clinical trials?
Sanofi's immunology pipeline is anchored by the dupilumab program (co-developed with Regeneron), covering atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyposis, eosinophilic esophagitis, COPD, and ongoing trials in additional type 2 inflammatory conditions. Beyond dupilumab, Sanofi has itepekimab (Dupixent anti-IL-33 sibling molecule) in late-stage trials for COPD and pediatric asthma, amlitelimab (anti-OX40L) in Phase 3 trials for atopic dermatitis and other inflammatory diseases, and frexalimab (anti-CD40L) in Phase 2 for multiple sclerosis. The breadth of Sanofi's immunology trial activity reflects a strategic decision to become a leading company in type 2 and B-cell-mediated inflammatory diseases.
What COVID-19 and respiratory virus trials does Sanofi run?
Sanofi partnered with GlaxoSmithKline to develop a COVID-19 recombinant protein subunit vaccine (VAT00002/Vidprevtyn Beta) that received EMA authorization. Sanofi Pasteur conducts active trials on quadrivalent influenza vaccines (including high-dose and adjuvanted formulations for older adults), RSV (respiratory syncytial virus) vaccine candidates in older adults and maternal programs, and mRNA-based influenza vaccine candidates leveraging the Translate Bio platform. The company also has active trials in dengue — Dengvaxia outcomes and safety surveillance studies — and investigational vaccines for other flaviviruses.

Clinical Trials by Sanofi

NCT06975722 Phase 2
Recruiting

A Study to Investigate the Efficacy and Safety of SAR442970 in Adult Participants With Ulcerative Colitis

Ulcerative Colitis
NCT07038473
Recruiting

Early Detection of Type 1 Diabetes in First Degree Relatives of Type 1 Diabetes Patients (DETECT T1D GULF)

Type 1 Diabetes
NCT05263206 Phase 3
Recruiting

Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)

Pruritus
NCT07612878
Recruiting

The Study of Chronic Obstructive Pulmonary Disease (COPD) Participants Treated With Dupilumab (STRIDE) Registry

COPD (Chronic Obstructive Pulmonary Disease)
NCT06192576
Recruiting

A Real-world Long-term Safety and Immunogenicity Study of Olipudase Alfa Therapy in Pediatric Patients Less Than 2 Years of Age With Acid Sphingomyelinase Deficiency (ASMD)

Niemann-Pick Diseases
NCT07380711
Recruiting

Long-term Real-world Study of Dupilumab in COPD : Patient Characteristics, Safety and Patient-reported Outcomes

Chronic Obstructive Pulmonary Disease COPD
NCT06684314
Recruiting

A Study to Evaluate Impact of Efanesoctocog Alfa on Long-term Joint Health in Participants With Hemophilia A in Taiwan

Hemophilia A
NCT07190222 Phase 3
Recruiting

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype

Chronic Obstructive Pulmonary Disease
NCT07086976 Phase 3
Recruiting

A Study to Investigate the Efficacy, Safety, and Pharmacokinetics of Oral Rilzabrutinib Compared With Placebo in Participants 18 Years of Age and Older With Warm Autoimmune Hemolytic Anemia

Autoimmune Haemolytic Anaemia
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