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sickle cell disease

Total Trials
25
Recruiting Now
25
Trial Phases
Phase 1, Phase 1, Phase 2, Phase 2, Phase 3

ClinicalMetric tracks all active clinical trials for sickle cell disease sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — sickle cell disease Clinical Trials

How many clinical trials are currently recruiting for sickle cell disease?
ClinicalMetric currently tracks 25 actively recruiting clinical trials for sickle cell disease, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 25. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for sickle cell disease?
sickle cell disease research spans Phase 1 (9 trials), Phase 2 (6 trials), Phase 3 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a sickle cell disease clinical trial?
Eligibility criteria for sickle cell disease trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
9
Phase 2
6
Phase 3
1
Top Sponsors
St. Jude Children's Research Hospital 5 trials
Emory University 2 trials
UConn Health 1 trial
University of Maryland, Baltimore 1 trial
Assistance Publique - Hôpitaux de Paris 1 trial

Recruiting Clinical Trials

NCT07083531
Recruiting
Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait
Enrollment
50 pts
Location
United States
Sponsor
UConn Health
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NCT07392216
Recruiting
Functional Ovarian Reserve in Sickle Cell Disease
Enrollment
440 pts
Location
United States
Sponsor
St. Jude Children's Research H...
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NCT07674277
Recruiting
Virtual Reality for SCD VOC
Enrollment
50 pts
Location
United States
Sponsor
University of Maryland, Baltim...
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NCT06823219
Recruiting
Long-term Endurance Training in Sickle Cell Disease Patients: Impact on Clinical Profile, Physical Fitness, and Quality of Life.
Enrollment
120 pts
Location
France
Sponsor
Assistance Publique - Hôpitaux...
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NCT01245179 Phase 1
Recruiting
Study of Panobinostat (LBH589) in Patients With Sickle Cell Disease
Enrollment
18 pts
Location
United States
Sponsor
Abdullah Kutlar
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NCT04398628
Recruiting
ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
Enrollment
3,000 pts
Location
United States
Sponsor
American Thrombosis and Hemost...
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NCT07610239
Recruiting
Evaluation of an Information Management and Communication System for Population-wide Point-of-Care Infant Sickle Cell Disease Screening
Enrollment
24,000 pts
Location
Uganda
Sponsor
Makerere University
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NCT07226219 Phase 1
Recruiting
Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
Enrollment
72 pts
Location
United States
Sponsor
St. Jude Children's Research H...
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NCT05377372
Recruiting
Early Life Exposures Among Children With Sickle Cell Disease
Enrollment
20 pts
Location
United States
Sponsor
University of Alabama at Birmi...
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NCT06477289
Recruiting
Peripheral Arterial Tonometry and Neurocognition in Sickle Cell Disease
Enrollment
65 pts
Location
United States
Sponsor
St. Jude Children's Research H...
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NCT04055818 Phase 1
Recruiting
A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease
Enrollment
20 pts
Location
United States
Sponsor
EpiDestiny, Inc.
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NCT07252050 Phase 1, Phase 2
Recruiting
Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease
Enrollment
24 pts
Location
United States
Sponsor
Arkansas Children's Hospital R...
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NCT02447874 Phase 1, Phase 2
Recruiting
Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease
Enrollment
21 pts
Location
United States
Sponsor
Emory University
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NCT05431088 Phase 2, Phase 3
Recruiting
A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
Enrollment
389 pts
Location
United States, Brazi...
Sponsor
Pfizer
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NCT06930703 Phase 1, Phase 2
Recruiting
Cannabidiol in Sickle Cell Disease
Enrollment
52 pts
Location
United States
Sponsor
Icahn School of Medicine at Mo...
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NCT06506461 Phase 1
Recruiting
Gene Editing For Sickle Cell Disease
Enrollment
25 pts
Location
United States
Sponsor
St. Jude Children's Research H...
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NCT06555939
Recruiting
Promoting Resilience Among Adolescents and Young Adults With Sickle Cell Disease
Enrollment
25 pts
Location
United States
Sponsor
Boston Children's Hospital
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NCT06301893
Recruiting
Uganda Sickle Surveillance Study (US-3)
Enrollment
1,000,000 pts
Location
Uganda
Sponsor
Children's Hospital Medical Ce...
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NCT07001189
Recruiting
Impact of Regional Anesthesia on Inflammatory Mechanisms During Vaso-occlusive Crisis in Sickle Cell Patients
Enrollment
34 pts
Location
Guadeloupe
Sponsor
Centre Hospitalier Universitai...
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NCT07090668
Recruiting
Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease
Enrollment
20 pts
Location
United States
Sponsor
Emory University
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NCT06635902 Phase 2
Recruiting
Intravenous L-Citrulline for Vaso-occlusive Pain Episode in Sickle Cell Disease
Enrollment
99 pts
Location
United States
Sponsor
Suvankar Majumdar
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NCT06442761 Phase 1
Recruiting
SCD Stem Cell Mobilization and Apheresis Using Motixafortide
Enrollment
20 pts
Location
United States
Sponsor
St. Jude Children's Research H...
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NCT07246265
Recruiting
Morphine Clearance and Glomerular Filtration in Sickle Cell Patients in Crisis in Intensive Care
Enrollment
100 pts
Location
France
Sponsor
University Hospital, Tours
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NCT04774536 Phase 1, Phase 2
Recruiting
Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease
Enrollment
9 pts
Location
United States
Sponsor
Mark Walters, MD
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NCT06944067
Recruiting
Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease
Enrollment
50 pts
Location
United States
Sponsor
National Human Genome Research...
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Related Conditions

vaso occlusive crises (2) sickle cell trait (1) hematologic disorder (1) bleeding disorder (1) connective tissue disorder (1) hemophilia (1) thrombosis (1) von willebrand diseases (1) thrombophilia (1) rare bleeding disorder (1) platelet disorder (1) factor ix deficiency (1)
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: November 2026  ·  Data Methodology