Medical Condition

sickle cell disease

Total Trials

22

Recruiting Now

22

Trial Phases

Phase 1, Phase 3, Phase 2

ClinicalMetric tracks all active clinical trials for sickle cell disease sourced from ClinicalTrials.gov. Each listing includes the NCT identifier, current recruitment status, phase, primary endpoints, sponsor, estimated enrollment, and participating countries — updated daily as new studies open and status changes.

Recruiting trials currently enrolling participants, with eligibility criteria and age requirements
Phase 1–4 studies from early safety trials to post-marketing surveillance
NIH, pharmaceutical sponsor, and academic medical center studies worldwide
AI-powered plain-language summary available for every trial listing

Frequently Asked Questions — sickle cell disease Clinical Trials

How many clinical trials are currently recruiting for sickle cell disease?

ClinicalMetric currently tracks 22 actively recruiting clinical trials for sickle cell disease, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 22. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for sickle cell disease?

sickle cell disease research spans Phase 1 (3 trials), Phase 2 (3 trials), Phase 3 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a sickle cell disease clinical trial?

Eligibility criteria for sickle cell disease trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Phase 2

Phase 3

Top Sponsors

St. Jude Children's Research Hospital 3 trials

Cairo University 1 trial

Duke University 1 trial

University Hospitals Cleveland Medical Center 1 trial

EpiDestiny, Inc. 1 trial

sickle cell disease

Frequently Asked Questions — sickle cell disease Clinical Trials

Recruiting Clinical Trials

Pulmonary Functions in Sickle Cell Disease: Response to Acu-TENS

SickleFit Exercise and Nutrition Study

Sickle Cell Disease Biofluid Chip Technology (SCD BioChip)

A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease

Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe β-Hemoglobinopathies

Study of a Single Dose of a 21-valent Pneumococcal Conjugate Vaccine in Children and Adolescents With Sickle Cell Disease

Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease

Arterial Function Parameters and Transcranial Doppler Velocity in Paediatric Patients With Sickle Cell Disease

A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)

Virtual Reality Devices as an Adjunct to Usual Care for Patients With Sickle Cell Disease Experiencing Vaso-Occlusive Crises

Let's Get REAL: Family Health Communication Tool in Pediatric Stem Cell Transplant and Cellular Therapy

Gene Therapy Communication: Use of a Needs Assessment to Drive Decision-AIDS for Gene Therapy for Rare Diseases (GENETX)

Promoting Utilization and Safety of Hydroxyurea Using Precision in Africa

School Readiness Intervention for Preschool Children With Sickle Cell Disease

Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling

Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

Empowering Adolescents and Young Adults With Sickle Cell Disease as Partners in Treatment Decision Making (EMPOWER-AYA)

Sickle-cell Disease Registry of the GPOH

Early Screening and Treatment of Heart Complication in Sickle Cell Disease

Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell Disease

MULTIsite Feasibility of MUSIc Therapy to Address Quality Of Life in Sickle Cell Disease

Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)