NCT07454824 e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most
| NCT ID | NCT07454824 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Johns Hopkins University |
| Condition | Dementia |
| Study Type | INTERVENTIONAL |
| Enrollment | 100 participants |
| Start Date | 2026-04-15 |
| Primary Completion | 2027-02-06 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 100 participants in total. It began in 2026-04-15 with a primary completion date of 2027-02-06.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational materials through the patient portal to engage the participant in deprescribing. The multicomponent intervention, e-Align, includes delivery of educational information through the patient portal, and a pharmacist-led intervention to align medications with patient and care partner goals and reduce use of central nervous system (CNS) potentially inappropriate medicines (PIM). This work will establish the preliminary data, methods, and partnerships to undertake a multisite embedded pragmatic clinical trial. The resulting triadic-based behavioral intervention will promote patient and care partner engagement, and foster care that aligns with patients' values, and promote improved health and well-being outcomes for people with cognitive impairment and the patient's care partners through deprescribing.
Eligibility Criteria
Inclusion Criteria: * Patients: Age ≥65, with a diagnosis of MCI or dementia based on ICD-10 codes and ≥1 active CNS-PIM, who are active patient portal users. Care partners: * Family or other companions \>21 years who regularly help the patient with managing medications. Exclusion Criteria: * As the trial will be based in primary care, individuals residing in long term care facilities or enrolled in hospice will be excluded.
Contact & Investigator
Ariel Green, MD, MPH, PhD
PRINCIPAL INVESTIGATOR
Johns Hopkins University
Frequently Asked Questions
Who can join the NCT07454824 clinical trial?
This trial is open to participants of all sexes, aged 65 Years or older, studying Dementia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07454824 currently recruiting?
Yes, NCT07454824 is actively recruiting participants. Contact the research team at ariel@jhmi.edu for enrollment information.
Where is the NCT07454824 trial being conducted?
This trial is being conducted at Baltimore, United States.
Who is sponsoring the NCT07454824 clinical trial?
NCT07454824 is sponsored by Johns Hopkins University. The principal investigator is Ariel Green, MD, MPH, PhD at Johns Hopkins University. The trial plans to enroll 100 participants.